登録情報 | データベース: PDB / ID: 4pln |
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タイトル | Crystal Structure of Chicken Netrin-1 (LN-LE3) complexed with mouse Neogenin (FN4-5) |
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要素 | |
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キーワード | PROTEIN BINDING / elongated / cysteine rich / glycoprotein / complex |
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機能・相同性 | 機能・相同性情報
regulation of glial cell migration / chemorepulsion of axon / Cdc42 protein signal transduction / anterior/posterior axon guidance / trans-synaptic signaling, modulating synaptic transmission / negative regulation of axon regeneration / motor neuron migration / co-receptor binding / negative regulation of axon extension / BMP receptor binding ...regulation of glial cell migration / chemorepulsion of axon / Cdc42 protein signal transduction / anterior/posterior axon guidance / trans-synaptic signaling, modulating synaptic transmission / negative regulation of axon regeneration / motor neuron migration / co-receptor binding / negative regulation of axon extension / BMP receptor binding / substrate-dependent cell migration, cell extension / regulation of axon regeneration / plasma membrane protein complex / positive regulation of BMP signaling pathway / myoblast fusion / positive regulation of cell motility / inner ear morphogenesis / nuclear migration / regulation of synapse assembly / intracellular vesicle / basement membrane / protein secretion / negative regulation of protein secretion / glial cell proliferation / positive regulation of axon extension / positive regulation of glial cell proliferation / cell periphery / postsynaptic density membrane / cell-cell adhesion / multicellular organismal-level iron ion homeostasis / actin cytoskeleton / signaling receptor activity / growth cone / Ras protein signal transduction / intracellular iron ion homeostasis / cell adhesion / cadherin binding / regulation of DNA-templated transcription / glutamatergic synapse / cell surface / Golgi apparatus / extracellular region / nucleoplasm / membrane / plasma membrane / cytosol類似検索 - 分子機能 Neogenin, C-terminal / Neogenin C-terminus / : / Laminin/attractin EGF domain / Laminin, N-terminal / : / Laminin N-terminal (Domain VI) / Laminin N-terminal domain profile. / Laminin N-terminal domain (domain VI) / Laminin-type EGF-like (LE) domain profile. ...Neogenin, C-terminal / Neogenin C-terminus / : / Laminin/attractin EGF domain / Laminin, N-terminal / : / Laminin N-terminal (Domain VI) / Laminin N-terminal domain profile. / Laminin N-terminal domain (domain VI) / Laminin-type EGF-like (LE) domain profile. / Laminin-type EGF-like (LE) domain signature. / Laminin-type epidermal growth factor-like domai / Laminin EGF domain / Laminin-type EGF domain / Netrin C-terminal Domain / Netrin module, non-TIMP type / UNC-6/NTR/C345C module / Netrin domain / NTR domain profile. / Tissue inhibitor of metalloproteinases-like, OB-fold / Immunoglobulin domain / Galactose-binding domain-like / Immunoglobulin I-set / Immunoglobulin I-set domain / Fibronectin type III domain / EGF-like domain signature 1. / Fibronectin type 3 domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Fibronectin type-III domain profile. / Galactose-binding-like domain superfamily / Fibronectin type III / Fibronectin type III superfamily / Immunoglobulin subtype / Immunoglobulin / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Jelly Rolls / Immunoglobulin-like fold / Immunoglobulins / Immunoglobulin-like / Sandwich / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 |  Gallus gallus (ニワトリ)
 Mus musculus (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.2 Å |
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データ登録者 | Xu, K. / Nikolov, D.B. |
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資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM103403 | 米国 | Department of Energy (DOE, United States) | DE-AC02-06CH11357 | 米国 |
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引用 | ジャーナル: Science / 年: 2014 タイトル: Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism. 著者: Xu, K. / Wu, Z. / Renier, N. / Antipenko, A. / Tzvetkova-Robev, D. / Xu, Y. / Minchenko, M. / Nardi-Dei, V. / Rajashankar, K.R. / Himanen, J. / Tessier-Lavigne, M. / Nikolov, D.B. |
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履歴 | 登録 | 2014年5月18日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2014年6月18日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2014年6月25日 | Group: Database references |
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改定 1.2 | 2015年2月25日 | Group: Derived calculations |
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改定 1.3 | 2017年9月27日 | Group: Advisory / Author supporting evidence ...Advisory / Author supporting evidence / Database references / Derived calculations / Other / Refinement description / Source and taxonomy / Structure summary カテゴリ: citation / entity ...citation / entity / entity_src_gen / entity_src_nat / pdbx_audit_support / pdbx_database_status / pdbx_struct_oper_list / pdbx_validate_symm_contact / software Item: _citation.journal_id_CSD / _entity.pdbx_description ..._citation.journal_id_CSD / _entity.pdbx_description / _entity_src_gen.pdbx_alt_source_flag / _entity_src_nat.pdbx_alt_source_flag / _pdbx_audit_support.funding_organization / _pdbx_database_status.pdb_format_compatible / _pdbx_struct_oper_list.symmetry_operation / _pdbx_validate_symm_contact.auth_asym_id_1 / _pdbx_validate_symm_contact.auth_asym_id_2 / _pdbx_validate_symm_contact.auth_atom_id_1 / _pdbx_validate_symm_contact.auth_atom_id_2 / _pdbx_validate_symm_contact.auth_comp_id_1 / _pdbx_validate_symm_contact.auth_comp_id_2 / _pdbx_validate_symm_contact.auth_seq_id_1 / _pdbx_validate_symm_contact.auth_seq_id_2 / _pdbx_validate_symm_contact.dist / _pdbx_validate_symm_contact.site_symmetry_2 |
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改定 1.4 | 2019年12月4日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.5 | 2020年7月29日 | Group: Data collection / Derived calculations ...Data collection / Derived calculations / Refinement description / Structure summary カテゴリ: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / refine_hist / struct_conn / struct_site / struct_site_gen Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _refine_hist.d_res_high / _refine_hist.pdbx_number_atoms_nucleic_acid / _refine_hist.pdbx_number_atoms_protein / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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改定 1.6 | 2023年12月27日 | Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / struct_ncs_dom_lim Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ..._chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id |
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改定 1.7 | 2024年10月30日 | Group: Structure summary カテゴリ: pdbx_entry_details / pdbx_modification_feature |
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