Entry | Database: PDB / ID: 4p4l |
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Title | Crystal Structure of Mycobacterium tuberculosis Shikimate Dehydrogenase |
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Components | Shikimate 5-dehydrogenase AroE (5-dehydroshikimate reductase) |
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Keywords | OXIDOREDUCTASE / AroE / Structural Genomics / TB Structural Genomics Consortium / TBSGC |
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Function / homology | Function and homology information
shikimate dehydrogenase (NADP+) / shikimate metabolic process / Chorismate via Shikimate Pathway / shikimate 3-dehydrogenase (NADP+) activity / chorismate biosynthetic process / NADP binding / protein homodimerization activity / cytosolSimilarity search - Function Shikimate dehydrogenase, AroM-type / Shikimate dehydrogenase family / SDH, C-terminal / Shikimate 5'-dehydrogenase C-terminal domain / Shikimate dehydrogenase substrate binding, N-terminal / Shikimate dehydrogenase substrate binding domain / Leucine Dehydrogenase, chain A, domain 1 / Aminoacid dehydrogenase-like, N-terminal domain superfamily / NAD(P)-binding Rossmann-like Domain / NAD(P)-binding domain superfamily ...Shikimate dehydrogenase, AroM-type / Shikimate dehydrogenase family / SDH, C-terminal / Shikimate 5'-dehydrogenase C-terminal domain / Shikimate dehydrogenase substrate binding, N-terminal / Shikimate dehydrogenase substrate binding domain / Leucine Dehydrogenase, chain A, domain 1 / Aminoacid dehydrogenase-like, N-terminal domain superfamily / NAD(P)-binding Rossmann-like Domain / NAD(P)-binding domain superfamily / Rossmann fold / 3-Layer(aba) Sandwich / Alpha BetaSimilarity search - Domain/homology |
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Biological species | ![](img/tx_bacteria.gif) Mycobacterium tuberculosis (bacteria) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.009 Å |
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Authors | Lalgondar, M. / Sacchettini, J.C. / TB Structural Genomics Consortium (TBSGC) |
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Funding support | United States, 1items Organization | Grant number | Country |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | | United States |
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Citation | Journal: To Be Published Title: Structure of Mycobacterium tuberculosis Shikimate Dehydrogenase Authors: Lalgondar, M. / Sacchettini, J.C. |
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History | Deposition | Mar 12, 2014 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Mar 18, 2015 | Provider: repository / Type: Initial release |
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Revision 1.1 | Sep 20, 2017 | Group: Advisory / Author supporting evidence ...Advisory / Author supporting evidence / Database references / Derived calculations / Other / Source and taxonomy Category: citation / entity_src_gen ...citation / entity_src_gen / pdbx_audit_support / pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list / pdbx_validate_symm_contact Item: _citation.journal_id_CSD / _entity_src_gen.pdbx_alt_source_flag ..._citation.journal_id_CSD / _entity_src_gen.pdbx_alt_source_flag / _pdbx_audit_support.funding_organization / _pdbx_database_status.pdb_format_compatible / _pdbx_struct_assembly.oligomeric_details / _pdbx_struct_oper_list.symmetry_operation / _pdbx_validate_symm_contact.auth_asym_id_1 / _pdbx_validate_symm_contact.auth_seq_id_1 / _pdbx_validate_symm_contact.auth_seq_id_2 / _pdbx_validate_symm_contact.dist / _pdbx_validate_symm_contact.site_symmetry_2 |
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Revision 1.2 | Dec 25, 2019 | Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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Revision 1.3 | Dec 27, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / refine_hist Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _refine_hist.pdbx_number_atoms_nucleic_acid / _refine_hist.pdbx_number_atoms_protein |
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Revision 1.4 | Mar 27, 2024 | Group: Refinement description / Category: pdbx_initial_refinement_model |
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