登録情報 | データベース: PDB / ID: 4mr5 |
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タイトル | Crystal Structure of the second bromodomain of human BRD2 in complex with a quinazolinone ligand (RVX-OH) |
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要素 | Bromodomain-containing protein 2 |
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キーワード | TRANSCRIPTION/TRANSCRIPTION inhibitor / BRD2 / RING3 / Small molecule inhibitor / RVX-OH / inhibitor complex / Structural Genomics Consortium / SGC / TRANSCRIPTION-TRANSCRIPTION inhibitor complex |
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機能・相同性 | 機能・相同性情報
acetylation-dependent protein binding / chromatin looping / RUNX3 regulates p14-ARF / positive regulation of T-helper 17 cell lineage commitment / protein localization to chromatin / neural tube closure / lysine-acetylated histone binding / nucleosome assembly / spermatogenesis / nuclear speck ...acetylation-dependent protein binding / chromatin looping / RUNX3 regulates p14-ARF / positive regulation of T-helper 17 cell lineage commitment / protein localization to chromatin / neural tube closure / lysine-acetylated histone binding / nucleosome assembly / spermatogenesis / nuclear speck / protein serine/threonine kinase activity / chromatin binding / chromatin / regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / cytoplasm類似検索 - 分子機能 NET domain superfamily / : / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site ...NET domain superfamily / : / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Up-down Bundle / Mainly Alpha類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 1.63 Å |
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データ登録者 | Filippakopoulos, P. / Picaud, S. / Felletar, I. / Martin, S. / Fedorov, O. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Weigelt, J. / Bountra, C. ...Filippakopoulos, P. / Picaud, S. / Felletar, I. / Martin, S. / Fedorov, O. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Weigelt, J. / Bountra, C. / Knapp, S. / Structural Genomics Consortium (SGC) |
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引用 | ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 2013 タイトル: RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. 著者: Picaud, S. / Wells, C. / Felletar, I. / Brotherton, D. / Martin, S. / Savitsky, P. / Diez-Dacal, B. / Philpott, M. / Bountra, C. / Lingard, H. / Fedorov, O. / Muller, S. / Brennan, P.E. / ...著者: Picaud, S. / Wells, C. / Felletar, I. / Brotherton, D. / Martin, S. / Savitsky, P. / Diez-Dacal, B. / Philpott, M. / Bountra, C. / Lingard, H. / Fedorov, O. / Muller, S. / Brennan, P.E. / Knapp, S. / Filippakopoulos, P. |
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履歴 | 登録 | 2013年9月17日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2013年11月27日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2014年1月22日 | Group: Database references |
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改定 1.2 | 2024年2月28日 | Group: Data collection / Database references / Derived calculations カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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