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-Structure paper
Title | RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 110, Page 19754-19759, Year 2013 |
Publish date | Sep 17, 2013 (structure data deposition date) |
Authors | Picaud, S. / Wells, C. / Felletar, I. / Brotherton, D. / Martin, S. / Savitsky, P. / Diez-Dacal, B. / Philpott, M. / Bountra, C. / Lingard, H. ...Picaud, S. / Wells, C. / Felletar, I. / Brotherton, D. / Martin, S. / Savitsky, P. / Diez-Dacal, B. / Philpott, M. / Bountra, C. / Lingard, H. / Fedorov, O. / Muller, S. / Brennan, P.E. / Knapp, S. / Filippakopoulos, P. |
External links | Proc. Natl. Acad. Sci. USA / PubMed:24248379 |
Methods | X-ray diffraction |
Resolution | 1.63 - 1.68 Å |
Structure data | PDB-4mr3: PDB-4mr4: PDB-4mr5: PDB-4mr6: |
Chemicals | ChemComp-EDO: ChemComp-1K0: ChemComp-HOH: ChemComp-DMS: |
Source |
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Keywords | TRANSCRIPTION/TRANSCRIPTION inhibitor / BRD4 / CAP / HUNK1 / MCAP / Mitotic chromosome associated protein / BRD / Small molecule inhibitor / RVX-OH / Structural Genomics Consortium / SGC / TRANSCRIPTION-TRANSCRIPTION inhibitor complex / RVX-208 / BRD2 / RING3 / inhibitor complex |