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Basic information
Entry | Database: PDB / ID: 4m4r | |||||||||
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Title | Epha4 ectodomain complex with ephrin a5 | |||||||||
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![]() | TRANSFERASE / eph receptor ephrin complex | |||||||||
Function / homology | ![]() neurotrophin TRKC receptor binding / neurotrophin TRKB receptor binding / DH domain binding / neuron projection fasciculation / positive regulation of Rho guanyl-nucleotide exchange factor activity / corticospinal tract morphogenesis / regulation of astrocyte differentiation / negative regulation of proteolysis involved in protein catabolic process / neuron projection guidance / nephric duct morphogenesis ...neurotrophin TRKC receptor binding / neurotrophin TRKB receptor binding / DH domain binding / neuron projection fasciculation / positive regulation of Rho guanyl-nucleotide exchange factor activity / corticospinal tract morphogenesis / regulation of astrocyte differentiation / negative regulation of proteolysis involved in protein catabolic process / neuron projection guidance / nephric duct morphogenesis / fasciculation of sensory neuron axon / fasciculation of motor neuron axon / regulation of synapse pruning / synapse pruning / positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process / negative regulation of cellular response to hypoxia / negative regulation of substrate adhesion-dependent cell spreading / negative regulation of axon regeneration / glial cell migration / transmembrane-ephrin receptor activity / regulation of cell-cell adhesion / synaptic membrane adhesion / PH domain binding / GPI-linked ephrin receptor activity / regulation of modification of synaptic structure / cellular response to follicle-stimulating hormone stimulus / collateral sprouting / positive regulation of collateral sprouting / regulation of insulin secretion involved in cellular response to glucose stimulus / regulation of dendritic spine morphogenesis / chemorepellent activity / neurotrophin TRKA receptor binding / negative regulation of cell adhesion / negative regulation of epithelial to mesenchymal transition / regulation of cell morphogenesis / motor neuron axon guidance / adult walking behavior / positive regulation of synapse assembly / adherens junction organization / positive regulation of dendrite morphogenesis / EPH-Ephrin signaling / Somitogenesis / regulation of focal adhesion assembly / positive regulation of amyloid-beta formation / regulation of axonogenesis / retinal ganglion cell axon guidance / cochlea development / regulation of GTPase activity / EPHA-mediated growth cone collapse / transmembrane receptor protein tyrosine kinase activator activity / positive regulation of protein tyrosine kinase activity / positive regulation of cell adhesion / negative regulation of long-term synaptic potentiation / basement membrane / EPH-ephrin mediated repulsion of cells / ephrin receptor signaling pathway / GABA-ergic synapse / axonal growth cone / regulation of microtubule cytoskeleton organization / axon terminus / cellular response to forskolin / ephrin receptor binding / protein tyrosine kinase binding / negative regulation of cell migration / filopodium / dendritic shaft / caveola / axon guidance / regulation of actin cytoskeleton organization / adherens junction / postsynaptic density membrane / neuromuscular junction / Schaffer collateral - CA1 synapse / receptor protein-tyrosine kinase / negative regulation of ERK1 and ERK2 cascade / peptidyl-tyrosine phosphorylation / cellular response to amyloid-beta / positive regulation of peptidyl-tyrosine phosphorylation / negative regulation of neuron projection development / kinase activity / nervous system development / presynaptic membrane / amyloid-beta binding / early endosome membrane / perikaryon / protein tyrosine kinase activity / mitochondrial outer membrane / protein autophosphorylation / dendritic spine / protein stabilization / negative regulation of translation / cell adhesion / protein kinase activity / positive regulation of cell migration / positive regulation of protein phosphorylation / external side of plasma membrane / axon / glutamatergic synapse / dendrite / positive regulation of cell population proliferation Similarity search - Function | |||||||||
Biological species | ![]() | |||||||||
Method | ![]() ![]() ![]() | |||||||||
![]() | Xu, K. / Tsvetkova-Robev, D. / Xu, Y. / Goldgur, Y. / Chan, Y.-P. / Himanen, J.P. / Nikolov, D.B. | |||||||||
![]() | ![]() Title: Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5. Authors: Xu, K. / Tzvetkova-Robev, D. / Xu, Y. / Goldgur, Y. / Chan, Y.P. / Himanen, J.P. / Nikolov, D.B. | |||||||||
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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-Related structure data
Related structure data | ![]() 4m4pC ![]() 2wo3S C: citing same article ( S: Starting model for refinement |
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Similar structure data |
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Assembly
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Component-ID: _ / Refine code: _
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