登録情報 | データベース: PDB / ID: 4m4d |
---|
タイトル | Crystal structure of lipopolysaccharide binding protein |
---|
要素 | Lipopolysaccharide-binding protein |
---|
キーワード | LIPID BINDING PROTEIN / beta barrel / immune response / lipopolysaccharide / blood |
---|
機能・相同性 | 機能・相同性情報
positive regulation of cytolysis / Transfer of LPS from LBP carrier to CD14 / positive regulation of tumor necrosis factor production => GO:0032760 / macromolecule localization / Toll Like Receptor 4 (TLR4) Cascade / Regulation of TLR by endogenous ligand / detection of molecule of bacterial origin / lipoteichoic acid binding / leukocyte chemotaxis involved in inflammatory response / opsonization ...positive regulation of cytolysis / Transfer of LPS from LBP carrier to CD14 / positive regulation of tumor necrosis factor production => GO:0032760 / macromolecule localization / Toll Like Receptor 4 (TLR4) Cascade / Regulation of TLR by endogenous ligand / detection of molecule of bacterial origin / lipoteichoic acid binding / leukocyte chemotaxis involved in inflammatory response / opsonization / positive regulation of toll-like receptor 4 signaling pathway / regulation of membrane permeability / lipopolysaccharide transport / positive regulation of phagocytosis, engulfment / lipopeptide binding / positive regulation of respiratory burst involved in inflammatory response / macrophage activation involved in immune response / positive regulation of macrophage activation / positive regulation of neutrophil chemotaxis / cellular response to lipoteichoic acid / negative regulation of tumor necrosis factor production / positive regulation of chemokine production / lipopolysaccharide-mediated signaling pathway / acute-phase response / positive regulation of interleukin-8 production / lipopolysaccharide binding / positive regulation of interleukin-6 production / positive regulation of tumor necrosis factor production / cellular response to lipopolysaccharide / defense response to Gram-negative bacterium / response to lipopolysaccharide / defense response to Gram-positive bacterium / innate immune response / signaling receptor binding / cell surface / extracellular space / membrane類似検索 - 分子機能 Lipopolysaccharide-binding protein / Lipid binding protein BPI/LBP / Bactericidal permeability-increasing protein; domain 2 / Bactericidal permeability-increasing protein; domain 2 / Lipid-binding serum glycoprotein, C-terminal / Lipid-binding serum glycoprotein, conserved site / LBP / BPI / CETP family, C-terminal domain / LBP / BPI / CETP family signature. / BPI/LBP/CETP N-terminal domain / BPI/LBP/CETP C-terminal domain ...Lipopolysaccharide-binding protein / Lipid binding protein BPI/LBP / Bactericidal permeability-increasing protein; domain 2 / Bactericidal permeability-increasing protein; domain 2 / Lipid-binding serum glycoprotein, C-terminal / Lipid-binding serum glycoprotein, conserved site / LBP / BPI / CETP family, C-terminal domain / LBP / BPI / CETP family signature. / BPI/LBP/CETP N-terminal domain / BPI/LBP/CETP C-terminal domain / Bactericidal permeability-increasing protein; domain 1 / Lipid-binding serum glycoprotein, N-terminal / Bactericidal permeability-increasing protein, alpha/beta domain superfamily / LBP / BPI / CETP family, N-terminal domain / Bactericidal permeability-increasing protein; domain 1 / Super Roll / Alpha Beta類似検索 - ドメイン・相同性 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE / Lipopolysaccharide-binding protein類似検索 - 構成要素 |
---|
生物種 | Mus musculus (ハツカネズミ) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.909 Å |
---|
データ登録者 | Eckert, J.K. / Kim, Y.J. / Kim, J.I. / Gurtler, K. / Oh, D.Y. / Ploeg, A.H. / Pickkers, P. / Lundvall, L. / Hamann, L. / Giamarellos-Bourboulis, E. ...Eckert, J.K. / Kim, Y.J. / Kim, J.I. / Gurtler, K. / Oh, D.Y. / Ploeg, A.H. / Pickkers, P. / Lundvall, L. / Hamann, L. / Giamarellos-Bourboulis, E. / Kubarenko, A.V. / Weber, A.N. / Kabesch, M. / Kumpf, O. / An, H.J. / Lee, J.O. / Schumann, R.R. |
---|
引用 | ジャーナル: Immunity / 年: 2013 タイトル: The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity. 著者: Eckert, J.K. / Kim, Y.J. / Kim, J.I. / Gurtler, K. / Oh, D.Y. / Sur, S. / Lundvall, L. / Hamann, L. / van der Ploeg, A. / Pickkers, P. / Giamarellos-Bourboulis, E. / Kubarenko, A.V. / Weber, ...著者: Eckert, J.K. / Kim, Y.J. / Kim, J.I. / Gurtler, K. / Oh, D.Y. / Sur, S. / Lundvall, L. / Hamann, L. / van der Ploeg, A. / Pickkers, P. / Giamarellos-Bourboulis, E. / Kubarenko, A.V. / Weber, A.N. / Kabesch, M. / Kumpf, O. / An, H.J. / Lee, J.O. / Schumann, R.R. |
---|
履歴 | 登録 | 2013年8月7日 | 登録サイト: RCSB / 処理サイト: PDBJ |
---|
改定 1.0 | 2013年10月30日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2015年6月17日 | Group: Database references |
---|
改定 1.2 | 2020年7月29日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Structure summary カテゴリ: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_ref_seq_dif / struct_site / struct_site_gen Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_ref_seq_dif.details 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
---|
改定 1.3 | 2023年11月8日 | Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
---|
|
---|