Entry Database : PDB / ID : 4ll3 Structure visualization Downloads & linksTitle Structure of wild-type HIV protease in complex with darunavir ComponentsProtease Details Keywords Hydrolase/Hydrolase Inhibitor / Hydrolase Inhibitor-darunavir / Hydrolase-Hydrolase Inhibitor complex / HIV-1 protease / TMC114Function / homology Function and homology informationFunction Domain/homology Component
viral genome integration into host DNA / establishment of integrated proviral latency / RNA stem-loop binding / RNA-directed DNA polymerase activity / endonuclease activity / aspartic-type endopeptidase activity / proteolysis / DNA binding Similarity search - Function Retropepsin-like catalytic domain / Reverse transcriptase (RNA-dependent DNA polymerase) / Reverse transcriptase domain / Reverse transcriptase (RT) catalytic domain profile. / Retropepsins / Retroviral aspartyl protease / Aspartyl protease, retroviral-type family profile. / Peptidase A2A, retrovirus, catalytic / Cathepsin D, subunit A; domain 1 / Acid Proteases ... Retropepsin-like catalytic domain / Reverse transcriptase (RNA-dependent DNA polymerase) / Reverse transcriptase domain / Reverse transcriptase (RT) catalytic domain profile. / Retropepsins / Retroviral aspartyl protease / Aspartyl protease, retroviral-type family profile. / Peptidase A2A, retrovirus, catalytic / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Reverse transcriptase/Diguanylate cyclase domain / DNA/RNA polymerase superfamily / Beta Barrel / Mainly Beta Similarity search - Domain/homologyBiological species Human immunodeficiency virus 1Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.95 Å DetailsAuthors Grantz Saskova, K. / Rezacova, P. / Brynda, J. / Kozisek, M. / Konvalinka, J. CitationJournal : Febs J. / Year : 2014Title : Thermodynamic and structural analysis of HIV protease resistance to darunavir - analysis of heavily mutated patient-derived HIV-1 proteases.Authors : Kozisek, M. / Lepsik, M. / Grantz Saskova, K. / Brynda, J. / Konvalinka, J. / Rezacova, P. History Deposition Jul 9, 2013 Deposition site : RCSB / Processing site : RCSBSupersession Apr 16, 2014 ID : 3QOZ Revision 1.0 Apr 16, 2014 Provider : repository / Type : Initial releaseRevision 1.1 Sep 24, 2014 Group : Database referencesRevision 1.2 Feb 28, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / diffrn_source / struct_ncs_dom_lim / struct_site Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ... _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _diffrn_source.pdbx_synchrotron_site / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_alt_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_alt_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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