登録情報 データベース : PDB / ID : 4kbq 構造の表示 ダウンロードとリンクタイトル Structure of the CHIP-TPR domain in complex with the Hsc70 Lid-Tail domains 要素E3 ubiquitin-protein ligase CHIP Heat shock cognate 71 kDa protein 詳細キーワード LIGASE/PROTEIN BINDING / TPR / E3 ubiquitin ligase / Hsc70 / LIGASE-PROTEIN BINDING complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
positive regulation of chaperone-mediated protein complex assembly / regulation of glucocorticoid metabolic process / lumenal side of lysosomal membrane / regulation of protein import / negative regulation of supramolecular fiber organization / positive regulation of protein refolding / prostaglandin binding / positive regulation of lysosomal membrane permeability / lysosomal matrix / A1 adenosine receptor binding ... positive regulation of chaperone-mediated protein complex assembly / regulation of glucocorticoid metabolic process / lumenal side of lysosomal membrane / regulation of protein import / negative regulation of supramolecular fiber organization / positive regulation of protein refolding / prostaglandin binding / positive regulation of lysosomal membrane permeability / lysosomal matrix / A1 adenosine receptor binding / protein carrier chaperone / response to nickel cation / ubiquitin conjugating enzyme complex / clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane / Respiratory syncytial virus genome transcription / protein transmembrane import into intracellular organelle / Lipophagy / positive regulation of ERAD pathway / chaperone-mediated autophagy translocation complex disassembly / slow axonal transport / clathrin-uncoating ATPase activity / GABA synthesis, release, reuptake and degradation / protein targeting to lysosome involved in chaperone-mediated autophagy / late endosomal microautophagy / response to odorant / positive regulation of mitophagy / positive regulation by host of viral genome replication / synaptic vesicle uncoating / ERBB2 signaling pathway / C3HC4-type RING finger domain binding / positive regulation of smooth muscle cell apoptotic process / negative regulation of NLRP3 inflammasome complex assembly / clathrin coat disassembly / ATP-dependent protein disaggregase activity / CHL1 interactions / regulation of protein complex stability / nuclear inclusion body / photoreceptor ribbon synapse / maintenance of postsynaptic specialization structure / misfolded protein binding / membrane organization / Prp19 complex / glycinergic synapse / presynaptic cytosol / postsynaptic specialization membrane / protein folding chaperone complex / cellular response to misfolded protein / positive regulation of mRNA splicing, via spliceosome / ubiquitin-ubiquitin ligase activity / postsynaptic cytosol / regulation of postsynapse organization / RIPK1-mediated regulated necrosis / negative regulation of cardiac muscle cell apoptotic process / Lysosome Vesicle Biogenesis / intermediate filament / chaperone-mediated autophagy / cellular response to steroid hormone stimulus / Golgi Associated Vesicle Biogenesis / TPR domain binding / phosphatidylserine binding / non-chaperonin molecular chaperone ATPase / protein quality control for misfolded or incompletely synthesized proteins / SMAD binding / protein monoubiquitination / negative regulation of smooth muscle cell apoptotic process / R-SMAD binding / protein K63-linked ubiquitination / positive regulation of proteolysis / protein maturation / chaperone cofactor-dependent protein refolding / HSF1-dependent transactivation / response to unfolded protein / estrous cycle / Regulation of HSF1-mediated heat shock response / regulation of protein-containing complex assembly / autophagosome / Attenuation phase / protein autoubiquitination / Protein methylation / ERAD pathway / ATP metabolic process / ubiquitin ligase complex / protein folding chaperone / endoplasmic reticulum unfolded protein response / skeletal muscle tissue development / positive regulation of phagocytosis / forebrain development / heat shock protein binding / Hsp70 protein binding / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / cellular response to cadmium ion / cellular response to starvation / photoreceptor inner segment / lysosomal lumen / mRNA Splicing - Major Pathway / Downregulation of TGF-beta receptor signaling / cerebellum development / dendritic shaft / response to activity / positive regulation of protein ubiquitination 類似検索 - 分子機能 CHIP, N-terminal tetratricopeptide repeat domain / CHIP/LubX , U box domain / CHIP N-terminal tetratricopeptide repeat domain / Substrate Binding Domain Of Dnak; Chain:A; Domain 2 - #10 / Anaphase-promoting complex, cyclosome, subunit 3 / U-box domain / U-box domain profile. / Modified RING finger domain / U-box domain / Heat shock hsp70 proteins family signature 2. ... CHIP, N-terminal tetratricopeptide repeat domain / CHIP/LubX , U box domain / CHIP N-terminal tetratricopeptide repeat domain / Substrate Binding Domain Of Dnak; Chain:A; Domain 2 - #10 / Anaphase-promoting complex, cyclosome, subunit 3 / U-box domain / U-box domain profile. / Modified RING finger domain / U-box domain / Heat shock hsp70 proteins family signature 2. / Heat shock hsp70 proteins family signature 1. / Heat shock hsp70 proteins family signature 3. / Heat shock protein 70, conserved site / Heat shock protein 70kD, peptide-binding domain superfamily / Heat shock protein 70 family / Hsp70 protein / Heat shock protein 70kD, C-terminal domain superfamily / Substrate Binding Domain Of Dnak; Chain:A; Domain 2 / Tetratricopeptide repeat domain / TPR repeat region circular profile. / TPR repeat profile. / Tetratricopeptide repeats / Tetratricopeptide repeat / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / ATPase, nucleotide binding domain / Alpha Horseshoe / Tetratricopeptide-like helical domain superfamily / Zinc finger, RING/FYVE/PHD-type / Up-down Bundle / Mainly Alpha 類似検索 - ドメイン・相同性 Heat shock cognate 71 kDa protein / E3 ubiquitin-protein ligase CHIP 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.91 Å 詳細データ登録者 Page, R.C. / Amick, J. / Nix, J.C. / Misra, S. 引用ジャーナル : Structure / 年 : 2015タイトル : A Bipartite Interaction between Hsp70 and CHIP Regulates Ubiquitination of Chaperoned Client Proteins.著者 : Zhang, H. / Amick, J. / Chakravarti, R. / Santarriaga, S. / Schlanger, S. / McGlone, C. / Dare, M. / Nix, J.C. / Scaglione, K.M. / Stuehr, D.J. / Misra, S. / Page, R.C. 履歴 登録 2013年4月23日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2015年1月14日 Provider : repository / タイプ : Initial release改定 1.1 2015年3月4日 Group : Database references改定 1.2 2015年3月18日 Group : Database references改定 1.3 2023年9月20日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details
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