登録情報 データベース : PDB / ID : 4h5n 構造の表示 ダウンロードとリンクタイトル HSC70 NBD with PO4, Na, Cl 要素Heat shock cognate 71 kDa protein 詳細 キーワード TRANSCRIPTION / Nucleotide Binding Domain機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
lumenal side of lysosomal membrane / regulation of protein import / negative regulation of supramolecular fiber organization / chaperone-mediated autophagy translocation complex disassembly / clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane / Lipophagy / Respiratory syncytial virus genome transcription / GABA synthesis, release, reuptake and degradation / protein targeting to lysosome involved in chaperone-mediated autophagy / protein carrier chaperone ... lumenal side of lysosomal membrane / regulation of protein import / negative regulation of supramolecular fiber organization / chaperone-mediated autophagy translocation complex disassembly / clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane / Lipophagy / Respiratory syncytial virus genome transcription / GABA synthesis, release, reuptake and degradation / protein targeting to lysosome involved in chaperone-mediated autophagy / protein carrier chaperone / clathrin coat disassembly / C3HC4-type RING finger domain binding / CHL1 interactions / negative regulation of NLRP3 inflammasome complex assembly / regulation of protein complex stability / ATP-dependent protein disaggregase activity / membrane organization / protein folding chaperone complex / Lysosome Vesicle Biogenesis / cellular response to steroid hormone stimulus / Golgi Associated Vesicle Biogenesis / chaperone-mediated autophagy / non-chaperonin molecular chaperone ATPase / : / Prp19 complex / HSF1-dependent transactivation / Regulation of HSF1-mediated heat shock response / response to unfolded protein / regulation of protein-containing complex assembly / Attenuation phase / Protein methylation / ATP metabolic process / heat shock protein binding / protein folding chaperone / mRNA Splicing - Major Pathway / lysosomal lumen / AUF1 (hnRNP D0) binds and destabilizes mRNA / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / cellular response to starvation / Late endosomal microautophagy / spliceosomal complex / ATP-dependent protein folding chaperone / G protein-coupled receptor binding / mRNA splicing, via spliceosome / PKR-mediated signaling / regulation of protein stability / Chaperone Mediated Autophagy / MHC class II protein complex binding / unfolded protein binding / Clathrin-mediated endocytosis / melanosome / protein folding / protein-folding chaperone binding / protein refolding / blood microparticle / secretory granule lumen / protein-macromolecule adaptor activity / Interleukin-4 and Interleukin-13 signaling / ficolin-1-rich granule lumen / positive regulation of cell migration / cadherin binding / receptor ligand activity / ribonucleoprotein complex / lysosomal membrane / focal adhesion / negative regulation of DNA-templated transcription / ubiquitin protein ligase binding / Neutrophil degranulation / nucleolus / enzyme binding / ATP hydrolysis activity / extracellular space / RNA binding / extracellular exosome / extracellular region / nucleoplasm / ATP binding / nucleus / membrane / plasma membrane / cytosol / cytoplasm 類似検索 - 分子機能 Defensin A-like - #30 / Defensin A-like / Heat shock hsp70 proteins family signature 2. / Heat shock hsp70 proteins family signature 1. / Heat shock hsp70 proteins family signature 3. / Heat shock protein 70, conserved site / Heat shock protein 70kD, peptide-binding domain superfamily / Heat shock protein 70 family / Hsp70 protein / Heat shock protein 70kD, C-terminal domain superfamily ... Defensin A-like - #30 / Defensin A-like / Heat shock hsp70 proteins family signature 2. / Heat shock hsp70 proteins family signature 1. / Heat shock hsp70 proteins family signature 3. / Heat shock protein 70, conserved site / Heat shock protein 70kD, peptide-binding domain superfamily / Heat shock protein 70 family / Hsp70 protein / Heat shock protein 70kD, C-terminal domain superfamily / ATPase, substrate binding domain, subdomain 4 / Actin; Chain A, domain 4 / ATPase, nucleotide binding domain / ATPase, nucleotide binding domain / Nucleotidyltransferase; domain 5 / Alpha-Beta Complex / 2-Layer Sandwich / Alpha Beta 類似検索 - ドメイン・相同性 PHOSPHATE ION / Heat shock cognate 71 kDa protein 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / 分子置換 / 解像度 : 1.86 Å 詳細データ登録者 Stec, B. 引用ジャーナル : Biochimie / 年 : 2015タイトル : New crystal structures of HSC-70 ATP binding domain confirm the role of individual binding pockets and suggest a new method of inhibition.著者 : Zhang, Z. / Cellitti, J. / Teriete, P. / Pellecchia, M. / Stec, B. 履歴 登録 2012年9月18日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2014年3月19日 Provider : repository / タイプ : Initial release改定 1.1 2014年12月17日 Group : Database references改定 1.2 2015年1月14日 Group : Database references改定 1.3 2023年9月20日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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