Entry Database : PDB / ID : 4gvc Structure visualization Downloads & linksTitle Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ in complex with phosphorylated Syndecan1 Peptide ComponentsSyndecan-1 T-lymphoma invasion and metastasis-inducing protein 1 DetailsKeywords SIGNALING PROTEIN / phosphorylation / peptide conformational change / new binding pocket / scaffold signaling protein for cell adhesion and cell junction / syndecan1 P1 Tyr phosphorylation / sydencan1 N-terminal Thr dansylationFunction / homology Function and homology informationFunction Domain/homology Component
myoblast development / positive regulation of Schwann cell chemotaxis / striated muscle cell development / regulation of non-canonical Wnt signaling pathway / regulation of dopaminergic neuron differentiation / Defective B3GALT6 causes EDSP2 and SEMDJL1 / Defective B4GALT7 causes EDS, progeroid type / Defective B3GAT3 causes JDSSDHD / Defective EXT2 causes exostoses 2 / Defective EXT1 causes exostoses 1, TRPS2 and CHDS ... myoblast development / positive regulation of Schwann cell chemotaxis / striated muscle cell development / regulation of non-canonical Wnt signaling pathway / regulation of dopaminergic neuron differentiation / Defective B3GALT6 causes EDSP2 and SEMDJL1 / Defective B4GALT7 causes EDS, progeroid type / Defective B3GAT3 causes JDSSDHD / Defective EXT2 causes exostoses 2 / Defective EXT1 causes exostoses 1, TRPS2 and CHDS / A tetrasaccharide linker sequence is required for GAG synthesis / extrinsic component of postsynaptic density membrane / HS-GAG biosynthesis / positive regulation of extracellular exosome assembly / HS-GAG degradation / Sertoli cell development / Activated NTRK2 signals through CDK5 / regulation of epithelial to mesenchymal transition / positive regulation of dendritic spine morphogenesis / regulation of modification of postsynaptic actin cytoskeleton / regulation of insulin secretion involved in cellular response to glucose stimulus / cell-cell contact zone / positive regulation of exosomal secretion / protein localization to membrane / cardiac muscle hypertrophy / activation of GTPase activity / regulation of small GTPase mediated signal transduction / cargo receptor activity / Wnt signaling pathway, planar cell polarity pathway / ureteric bud development / neuron projection extension / main axon / Syndecan interactions / Other interleukin signaling / positive regulation of axonogenesis / small GTPase-mediated signal transduction / RSV-host interactions / NRAGE signals death through JNK / Rac protein signal transduction / Respiratory syncytial virus (RSV) attachment and entry / CDC42 GTPase cycle / RHOA GTPase cycle / EPH-ephrin mediated repulsion of cells / ephrin receptor signaling pathway / RAC2 GTPase cycle / RAC3 GTPase cycle / canonical Wnt signaling pathway / axonal growth cone / positive regulation of epithelial to mesenchymal transition / Retinoid metabolism and transport / response to glucocorticoid / response to cAMP / EPHB-mediated forward signaling / RAC1 GTPase cycle / lysosomal lumen / regulation of ERK1 and ERK2 cascade / guanyl-nucleotide exchange factor activity / cell-matrix adhesion / receptor-mediated endocytosis / response to cocaine / Cell surface interactions at the vascular wall / response to hydrogen peroxide / response to toxic substance / receptor tyrosine kinase binding / kinase binding / ruffle membrane / response to calcium ion / Golgi lumen / G alpha (12/13) signalling events / cell-cell junction / cell migration / positive regulation of protein binding / microtubule binding / protein-containing complex assembly / microtubule / dendritic spine / Attachment and Entry / positive regulation of cell migration / external side of plasma membrane / neuronal cell body / glutamatergic synapse / lipid binding / synapse / positive regulation of cell population proliferation / cell surface / protein-containing complex / extracellular exosome / identical protein binding / plasma membrane / cytosol Similarity search - Function Syndecan / Syndecan, conserved site / Syndecans signature. / TIAM1, CC-Ex domain / Tiam1/Tiam2/Protein still life / T-lymphoma invasion and metastasis CC-Ex domain / Syndecan/Neurexin domain / Syndecan domain / Neurexin/syndecan/glycophorin C / putative band 4.1 homologues' binding motif ... Syndecan / Syndecan, conserved site / Syndecans signature. / TIAM1, CC-Ex domain / Tiam1/Tiam2/Protein still life / T-lymphoma invasion and metastasis CC-Ex domain / Syndecan/Neurexin domain / Syndecan domain / Neurexin/syndecan/glycophorin C / putative band 4.1 homologues' binding motif / Guanine-nucleotide dissociation stimulator, CDC24, conserved site / Dbl homology (DH) domain signature. / Raf-like Ras-binding domain / Raf-like Ras-binding / Ras-binding domain (RBD) profile. / Raf-like Ras-binding domain / Dbl homology (DH) domain superfamily / RhoGEF domain / Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases / Dbl homology (DH) domain / Dbl homology (DH) domain profile. / PDZ domain / Pdz3 Domain / PH domain / PH domain profile. / PDZ domain / Pleckstrin homology domain. / Pleckstrin homology domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / PH-like domain superfamily / Roll / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.54 Å DetailsAuthors Liu, X. / Shepherd, T.R. / Murray, A.M. / Xu, Z. / Fuentes, E.J. CitationJournal : Structure / Year : 2013Title : The structure of the Tiam1 PDZ domain/ phospho-syndecan1 complex reveals a ligand conformation that modulates protein dynamics.Authors : Liu, X. / Shepherd, T.R. / Murray, A.M. / Xu, Z. / Fuentes, E.J. History Deposition Aug 30, 2012 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Mar 13, 2013 Provider : repository / Type : Initial releaseRevision 1.1 May 27, 2015 Group : Database referencesRevision 1.2 Sep 13, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id Revision 1.3 Dec 6, 2023 Group : Data collection / Category : chem_comp_atom / chem_comp_bond / Item : _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_2
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