Entry Database : PDB / ID : 4dx8 Structure visualization Downloads & linksTitle ICAP1 in complex with KRIT1 N-terminus ComponentsIntegrin beta-1-binding protein 1 Krev interaction trapped protein 1 DetailsKeywords PROTEIN BINDING / Protein-protein complex / PTB domain / Nudix fold / Protein-protein interaction / Membrane / nucleusFunction / homology Function and homology informationFunction Domain/homology Component
negative regulation of protein targeting to membrane / regulation of integrin-mediated signaling pathway / negative regulation of cell adhesion involved in substrate-bound cell migration / biomineral tissue development / myoblast migration / negative regulation of substrate adhesion-dependent cell spreading / GTPase regulator activity / blood vessel endothelial cell proliferation involved in sprouting angiogenesis / endothelium development / negative regulation of focal adhesion assembly ... negative regulation of protein targeting to membrane / regulation of integrin-mediated signaling pathway / negative regulation of cell adhesion involved in substrate-bound cell migration / biomineral tissue development / myoblast migration / negative regulation of substrate adhesion-dependent cell spreading / GTPase regulator activity / blood vessel endothelial cell proliferation involved in sprouting angiogenesis / endothelium development / negative regulation of focal adhesion assembly / integrin activation / tube formation / negative regulation of cell migration involved in sprouting angiogenesis / negative regulation of fibroblast migration / cellular response to fibroblast growth factor stimulus / GDP-dissociation inhibitor activity / regulation of establishment of cell polarity / negative regulation of endothelial cell migration / small GTPase-mediated signal transduction / regulation of GTPase activity / positive regulation of Notch signaling pathway / receptor clustering / negative regulation of endothelial cell proliferation / positive regulation of focal adhesion assembly / regulation of cell adhesion mediated by integrin / positive regulation of cell division / centriolar satellite / positive regulation of protein targeting to membrane / cellular response to vascular endothelial growth factor stimulus / regulation of angiogenesis / negative regulation of endothelial cell apoptotic process / Notch signaling pathway / positive regulation of stress fiber assembly / ruffle / phosphatidylinositol-4,5-bisphosphate binding / activation of protein kinase B activity / positive regulation of endothelial cell migration / blood vessel diameter maintenance / negative regulation of angiogenesis / cell-matrix adhesion / cell redox homeostasis / negative regulation of protein binding / cell periphery / protein localization to plasma membrane / integrin-mediated signaling pathway / negative regulation of protein kinase activity / negative regulation of ERK1 and ERK2 cascade / cell-cell junction / cell migration / integrin binding / lamellipodium / microtubule binding / angiogenesis / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / cell differentiation / cytoskeleton / nuclear body / intracellular signal transduction / negative regulation of cell population proliferation / positive regulation of cell population proliferation / protein kinase binding / perinuclear region of cytoplasm / positive regulation of transcription by RNA polymerase II / protein-containing complex / extracellular space / nucleoplasm / membrane / nucleus / plasma membrane / cytoplasm / cytosol Similarity search - Function KRIT, N-terminal Nudix domain, NPxY motif-rich region / Integrin binding protein, ICAP-1 / Beta-1 integrin binding protein / KRIT, N-terminal NPxY motif-rich region / Krev interaction trapped protein 1, FERM domain C-lobe / KRIT, N-terminal NPxY motif-rich domain superfamily / NUDIX, or N-terminal NPxY motif-rich, region of KRIT / Ankyrin repeats (many copies) / Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain / PTB/PI domain ... KRIT, N-terminal Nudix domain, NPxY motif-rich region / Integrin binding protein, ICAP-1 / Beta-1 integrin binding protein / KRIT, N-terminal NPxY motif-rich region / Krev interaction trapped protein 1, FERM domain C-lobe / KRIT, N-terminal NPxY motif-rich domain superfamily / NUDIX, or N-terminal NPxY motif-rich, region of KRIT / Ankyrin repeats (many copies) / Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain / PTB/PI domain / FERM central domain / FERM/acyl-CoA-binding protein superfamily / Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) / PH-domain like / FERM central domain / FERM superfamily, second domain / FERM domain / FERM domain profile. / Band 4.1 domain / Band 4.1 homologues / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily / PH-like domain superfamily / Roll / Alpha-Beta Plaits / 2-Layer Sandwich / Mainly Beta / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.54 Å DetailsAuthors Liu, W. / Draheim, K. / Zhang, R. / Calderwood, D.A. / Boggon, T.J. CitationJournal : Mol.Cell / Year : 2013Title : Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation.Authors : Liu, W. / Draheim, K.M. / Zhang, R. / Calderwood, D.A. / Boggon, T.J. History Deposition Feb 27, 2012 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jan 9, 2013 Provider : repository / Type : Initial releaseRevision 1.1 Jan 30, 2013 Group : Database referencesRevision 1.2 Mar 13, 2013 Group : Database referencesRevision 1.3 Sep 2, 2020 Group : Database references / Derived calculations / Structure summaryCategory : struct_keywords / struct_ref_seq_dif / struct_siteItem : _struct_keywords.text / _struct_ref_seq_dif.details ... _struct_keywords.text / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id Revision 1.4 Feb 28, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_ncs_dom_lim Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id
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