登録情報 | データベース: PDB / ID: 4d2s |
---|
タイトル | Human TTK in complex with a Dyrk1B inhibitor |
---|
要素 | DUAL SPECIFICITY PROTEIN KINASE TTK |
---|
キーワード | TRANSFERASE / ONCOLOGY |
---|
機能・相同性 | 機能・相同性情報
protein localization to meiotic spindle midzone / meiotic spindle assembly checkpoint signaling / kinetochore binding / female meiosis chromosome segregation / protein localization to kinetochore / dual-specificity kinase / spindle organization / mitotic spindle assembly checkpoint signaling / protein serine/threonine/tyrosine kinase activity / mitotic spindle organization ...protein localization to meiotic spindle midzone / meiotic spindle assembly checkpoint signaling / kinetochore binding / female meiosis chromosome segregation / protein localization to kinetochore / dual-specificity kinase / spindle organization / mitotic spindle assembly checkpoint signaling / protein serine/threonine/tyrosine kinase activity / mitotic spindle organization / chromosome segregation / kinetochore / spindle / protein tyrosine kinase activity / phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / positive regulation of cell population proliferation / ATP binding / identical protein binding / membrane / nucleus / cytoplasm類似検索 - 分子機能 Protein kinase Mps1 family / Tetratricopeptide-like helical domain superfamily / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain ...Protein kinase Mps1 family / Tetratricopeptide-like helical domain superfamily / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Chem-DYK / Dual specificity protein kinase TTK類似検索 - 構成要素 |
---|
生物種 | HOMO SAPIENS (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.5 Å |
---|
データ登録者 | Debreczeni, J.E. / Kettle, J.G. / Ballard, P. / Bardelle, C. / Butterworth, S. / Colclough, N. / Critchlow, S.E. / Fairley, G. / Fillery, S. / Graham, M.A. ...Debreczeni, J.E. / Kettle, J.G. / Ballard, P. / Bardelle, C. / Butterworth, S. / Colclough, N. / Critchlow, S.E. / Fairley, G. / Fillery, S. / Graham, M.A. / Goodwin, L. / Guichard, S. / Hudson, K. / Mahmood, A. / Vincent, J. / Ward, R.A. / Whittaker, D. |
---|
引用 | ジャーナル: J.Med.Chem. / 年: 2015 タイトル: Discovery and Optimization of a Novel Series of Dyrk1B Kinase Inhibitors to Explore a Mek Resistance Hypothesis. 著者: Kettle, J.G. / Ballard, P. / Bardelle, C. / Cockerill, M. / Colclough, N. / Critchlow, S.E. / Debreczeni, J.E. / Fairley, G. / Fillery, S. / Graham, M.A. / Goodwin, L. / Guichard, S. / ...著者: Kettle, J.G. / Ballard, P. / Bardelle, C. / Cockerill, M. / Colclough, N. / Critchlow, S.E. / Debreczeni, J.E. / Fairley, G. / Fillery, S. / Graham, M.A. / Goodwin, L. / Guichard, S. / Hudson, K. / Ward, R.A. / Whittaker, D. |
---|
履歴 | 登録 | 2014年5月12日 | 登録サイト: PDBE / 処理サイト: PDBE |
---|
改定 1.0 | 2015年4月22日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2019年10月23日 | Group: Data collection / Experimental preparation ...Data collection / Experimental preparation / Other / Structure summary カテゴリ: audit_author / exptl_crystal_grow / pdbx_database_status Item: _audit_author.name / _exptl_crystal_grow.method / _pdbx_database_status.status_code_sf |
---|
改定 1.2 | 2024年5月8日 | Group: Data collection / Database references / Derived calculations カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
---|
|
---|