- PDB-4cgy: Crystal structure of the human topoisomerase III alpha-RMI1 complex -
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基本情報
登録情報
データベース: PDB / ID: 4cgy
タイトル
Crystal structure of the human topoisomerase III alpha-RMI1 complex
要素
DNA TOPOISOMERASE 3-ALPHA
RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1
キーワード
DNA REPLICATION/ISOMERASE / DNA REPLICATION-ISOMERASE COMPLEX / DOUBLE HOLLIDAY JUNCTION DISSOLUTION / DECATENATION / MINIMAL DISSOLVASOME
機能・相同性
機能・相同性情報
RecQ family helicase-topoisomerase III complex / reduction of food intake in response to dietary excess / DNA topoisomerase activity / resolution of DNA recombination intermediates / chromosome separation / DNA topoisomerase / DNA topoisomerase type I (single strand cut, ATP-independent) activity / resolution of meiotic recombination intermediates / mitochondrial DNA metabolic process / Impaired BRCA2 binding to PALB2 ...RecQ family helicase-topoisomerase III complex / reduction of food intake in response to dietary excess / DNA topoisomerase activity / resolution of DNA recombination intermediates / chromosome separation / DNA topoisomerase / DNA topoisomerase type I (single strand cut, ATP-independent) activity / resolution of meiotic recombination intermediates / mitochondrial DNA metabolic process / Impaired BRCA2 binding to PALB2 / Defective homologous recombination repair (HRR) due to BRCA1 loss of function / Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function / Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function / Homologous DNA Pairing and Strand Exchange / Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) / Resolution of D-loop Structures through Holliday Junction Intermediates / HDR through Single Strand Annealing (SSA) / Impaired BRCA2 binding to RAD51 / Presynaptic phase of homologous DNA pairing and strand exchange / DNA topological change / response to glucose / meiotic cell cycle / double-strand break repair via homologous recombination / HDR through Homologous Recombination (HRR) / G2/M DNA damage checkpoint / multicellular organism growth / PML body / Meiotic recombination / glucose homeostasis / single-stranded DNA binding / Processing of DNA double-strand break ends / DNA replication / Regulation of TP53 Activity through Phosphorylation / nuclear body / mitochondrial matrix / nucleotide binding / DNA binding / zinc ion binding / nucleoplasm / nucleus 類似検索 - 分子機能
RecQ-mediated genome instability protein 1, N-terminal domain / RecQ-mediated genome instability protein Rmi1, C-terminal domain / RecQ-mediated genome instability protein 1, C-terminal OB-fold domain / RecQ-mediated genome instability protein 1, N-terminal helical domain superfamily / : / Recq-mediated genome instability protein 1, C-terminal OB-fold / RMI1, N-terminal helical domain / DUF1767 / Zinc finger GRF-type profile. / Zinc finger, GRF-type ...RecQ-mediated genome instability protein 1, N-terminal domain / RecQ-mediated genome instability protein Rmi1, C-terminal domain / RecQ-mediated genome instability protein 1, C-terminal OB-fold domain / RecQ-mediated genome instability protein 1, N-terminal helical domain superfamily / : / Recq-mediated genome instability protein 1, C-terminal OB-fold / RMI1, N-terminal helical domain / DUF1767 / Zinc finger GRF-type profile. / Zinc finger, GRF-type / GRF zinc finger / DNA topoisomerase, type IA, zn finger / DNA topoisomerase 3-like, TOPRIM domain / Topoisomerase DNA binding C4 zinc finger / RecQ mediated genome instability protein 1, N-terminal / RecQ mediated genome instability protein, N-terminal OB-fold superfamily / RMI1, N-terminal OB-fold domain / Topoisomerase I, domain 3 / Topoisomerase I; domain 2 / Topoisomerase I, domain 2 / Rossmann fold - #140 / Topoisomerase I; domain 4 / Topoisomerase I, domain 4 / DNA topoisomerase, type IA / DNA topoisomerase, type IA, central region, subdomain 2 / DNA topoisomerase, type IA, active site / Topoisomerase (Topo) IA-type active site signature. / Topoisomerase (Topo) IA-type catalytic domain profile. / Topoisomerase I; domain 3 / DNA topoisomerase, type IA, domain 2 / DNA topoisomerase, type IA, DNA-binding domain / DNA topoisomerase, type IA, central / DNA topoisomerase, type IA, central region, subdomain 1 / DNA topoisomerase, type IA, central region, subdomain 3 / DNA topoisomerase, type IA, core domain / DNA topoisomerase / Bacterial DNA topoisomeraes I ATP-binding domain / Bacterial DNA topoisomerase I DNA-binding domain / TOPRIM / Toprim domain / Toprim domain profile. / TOPRIM domain / Helicase, Ruva Protein; domain 3 / Distorted Sandwich / OB fold (Dihydrolipoamide Acetyltransferase, E2P) / Beta Barrel / Rossmann fold / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Beta / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性
DNA topoisomerase 3-alpha / RecQ-mediated genome instability protein 1 類似検索 - 構成要素