Entry Database : PDB / ID : 4b18 Structure visualization Downloads & linksTitle The crystal structure of human Importin alpha 5 with TERT NLS peptide ComponentsIMPORTIN SUBUNIT ALPHA-1 TELOMERASE REVERSE TRANSCRIPTASE DetailsKeywords TRANSPORT PROTEIN / PEPTIDE / TRANSPORT PROTEIN - PEPTIDE COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
satellite cell activation involved in skeletal muscle regeneration / skeletal muscle satellite cell proliferation / positive regulation of hair cycle / template-free RNA nucleotidyltransferase / positive regulation of transdifferentiation / TERT-RMRP complex / DNA strand elongation / RNA-directed RNA polymerase complex / Inhibition of nitric oxide production / siRNA transcription ... satellite cell activation involved in skeletal muscle regeneration / skeletal muscle satellite cell proliferation / positive regulation of hair cycle / template-free RNA nucleotidyltransferase / positive regulation of transdifferentiation / TERT-RMRP complex / DNA strand elongation / RNA-directed RNA polymerase complex / Inhibition of nitric oxide production / siRNA transcription / positive regulation of protein localization to nucleolus / telomerase catalytic core complex / RNA-templated DNA biosynthetic process / : / regulation of DNA recombination / establishment of protein localization to telomere / telomerase activity / Transport of Ribonucleoproteins into the Host Nucleus / nuclear telomere cap complex / NS1 Mediated Effects on Host Pathways / NLS-dependent protein nuclear import complex / Apoptosis induced DNA fragmentation / siRNA processing / postsynapse to nucleus signaling pathway / telomerase holoenzyme complex / positive regulation of vascular associated smooth muscle cell migration / telomerase RNA binding / regulation of canonical Wnt signaling pathway / nuclear import signal receptor activity / nuclear localization sequence binding / NLS-bearing protein import into nucleus / DNA biosynthetic process / RNA-templated transcription / telomeric DNA binding / positive regulation of stem cell proliferation / Vpr-mediated nuclear import of PICs / mitochondrial nucleoid / Integration of provirus / negative regulation of cellular senescence / Telomere Extension By Telomerase / telomere maintenance via telomerase / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / replicative senescence / positive regulation of Wnt signaling pathway / positive regulation of G1/S transition of mitotic cell cycle / negative regulation of endothelial cell apoptotic process / nuclear pore / response to cadmium ion / positive regulation of vascular associated smooth muscle cell proliferation / telomere maintenance / Assembly of the ORC complex at the origin of replication / mitochondrion organization / positive regulation of nitric-oxide synthase activity / positive regulation of glucose import / Formation of the beta-catenin:TCF transactivating complex / regulation of protein stability / ISG15 antiviral mechanism / PML body / transcription coactivator binding / positive regulation of miRNA transcription / RNA-directed DNA polymerase / protein import into nucleus / positive regulation of angiogenesis / RNA-directed DNA polymerase activity / Interferon alpha/beta signaling / positive regulation of protein binding / protein-folding chaperone binding / cellular response to hypoxia / regulation of apoptotic process / negative regulation of neuron apoptotic process / chromosome, telomeric region / tRNA binding / postsynaptic density / nuclear speck / negative regulation of gene expression / RNA-dependent RNA polymerase activity / glutamatergic synapse / dendrite / nucleolus / protein homodimerization activity / DNA binding / RNA binding / nucleoplasm / identical protein binding / nucleus / metal ion binding / plasma membrane / cytoplasm / cytosol Similarity search - Function : / Telomerase reverse transcriptase, C-terminal extension / Telomerase ribonucleoprotein complex - RNA binding domain / Telomerase reverse transcriptase / Telomerase ribonucleoprotein complex - RNA-binding domain / Telomerase ribonucleoprotein complex - RNA binding domain / Importin subunit alpha / Atypical Arm repeat / Importin-alpha, importin-beta-binding domain superfamily / Importin beta binding domain ... : / Telomerase reverse transcriptase, C-terminal extension / Telomerase ribonucleoprotein complex - RNA binding domain / Telomerase reverse transcriptase / Telomerase ribonucleoprotein complex - RNA-binding domain / Telomerase ribonucleoprotein complex - RNA binding domain / Importin subunit alpha / Atypical Arm repeat / Importin-alpha, importin-beta-binding domain superfamily / Importin beta binding domain / Atypical Arm repeat / Importin-alpha, importin-beta-binding domain / IBB domain profile. / Armadillo/plakoglobin ARM repeat profile. / Armadillo/beta-catenin-like repeat / Armadillo/beta-catenin-like repeats / Armadillo / Leucine-rich Repeat Variant / Leucine-rich Repeat Variant / Reverse transcriptase (RNA-dependent DNA polymerase) / Reverse transcriptase domain / Reverse transcriptase (RT) catalytic domain profile. / Armadillo-like helical / Alpha Horseshoe / Armadillo-type fold / DNA/RNA polymerase superfamily / Mainly Alpha Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.52 Å DetailsAuthors Kim, K.L. / Yoo, J.H. / Cho, H.S. CitationJournal : J.Cell.Sci. / Year : 2015Title : Akt-Mediated Phosphorylation Increases the Binding Affinity of Htert for Importin Alpha to Promote Nuclear Translocation.Authors : Jeong, S.A. / Kim, K. / Lee, J.H. / Cha, J.S. / Khadka, P. / Cho, H. / Chung, I.K. History Deposition Jul 8, 2012 Deposition site : PDBE / Processing site : PDBERevision 1.0 Sep 4, 2013 Provider : repository / Type : Initial releaseRevision 1.1 Apr 22, 2015 Group : Database referencesRevision 1.2 Apr 29, 2015 Group : Derived calculations / Source and taxonomyRevision 1.3 Jun 24, 2015 Group : Database referencesRevision 1.4 Jul 1, 2015 Group : Database referencesRevision 1.5 Dec 20, 2023 Group : Data collection / Database references ... Data collection / Database references / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf
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