Entry | Database: PDB / ID: 4alu |
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Title | Benzofuropyrimidinone Inhibitors of Pim-1 |
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Components | SERINE/THREONINE-PROTEIN KINASE PIM-1 |
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Keywords | TRANSFERASE / PROTO-ONCOGENE |
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Function / homology | Function and homology information
positive regulation of cardioblast proliferation / regulation of hematopoietic stem cell proliferation / vitamin D receptor signaling pathway / cellular detoxification / STAT5 activation downstream of FLT3 ITD mutants / transcription factor binding / positive regulation of cyclin-dependent protein serine/threonine kinase activity / ribosomal small subunit binding / positive regulation of cardiac muscle cell proliferation / Signaling by FLT3 fusion proteins ...positive regulation of cardioblast proliferation / regulation of hematopoietic stem cell proliferation / vitamin D receptor signaling pathway / cellular detoxification / STAT5 activation downstream of FLT3 ITD mutants / transcription factor binding / positive regulation of cyclin-dependent protein serine/threonine kinase activity / ribosomal small subunit binding / positive regulation of cardiac muscle cell proliferation / Signaling by FLT3 fusion proteins / positive regulation of TORC1 signaling / negative regulation of innate immune response / positive regulation of brown fat cell differentiation / protein serine/threonine kinase activator activity / regulation of transmembrane transporter activity / positive regulation of protein serine/threonine kinase activity / negative regulation of DNA-binding transcription factor activity / cellular response to type II interferon / manganese ion binding / Interleukin-4 and Interleukin-13 signaling / protein autophosphorylation / protein stabilization / non-specific serine/threonine protein kinase / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / nucleolus / negative regulation of apoptotic process / apoptotic process / positive regulation of DNA-templated transcription / nucleoplasm / ATP binding / nucleus / plasma membrane / cytosol / cytoplasmSimilarity search - Function Serine/threonine-protein kinase pim-1/2/3 / : / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain ...Serine/threonine-protein kinase pim-1/2/3 / : / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha BetaSimilarity search - Domain/homology |
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Biological species | HOMO SAPIENS (human) |
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Method | X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution: 2.6 Å |
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Authors | Stout, T.J. / Adams, L. |
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Citation | Journal: Bioorg.Med.Chem.Lett. / Year: 2012 Title: The Design, Synthesis, and Biological Evaluation of Pim Kinase Inhibitors. Authors: Tsuhako, A.L. / Brown, D.S. / Koltun, E.S. / Aay, N. / Arcalas, A. / Chan, V. / Du, H. / Engst, S. / Franzini, M. / Galan, A. / Huang, P. / Johnston, S. / Kane, B. / Kim, M.H. / Laird, A.D. ...Authors: Tsuhako, A.L. / Brown, D.S. / Koltun, E.S. / Aay, N. / Arcalas, A. / Chan, V. / Du, H. / Engst, S. / Franzini, M. / Galan, A. / Huang, P. / Johnston, S. / Kane, B. / Kim, M.H. / Laird, A.D. / Lin, R. / Mock, L. / Ngan, I. / Pack, M. / Stott, G. / Stout, T.J. / Yu, P. / Zaharia, C. / Zhang, W. / Zhou, P. / Nuss, J.M. / Kearney, P.C. / Xu, W. |
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History | Deposition | Mar 5, 2012 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Jan 16, 2013 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jun 28, 2017 | Group: Data collection / Category: diffrn_source / Item: _diffrn_source.type |
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Revision 1.2 | May 1, 2024 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Other / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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