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- PDB-3zd1: STRUCTURE OF THE TWO C-TERMINAL DOMAINS OF COMPLEMENT FACTOR H RE... -
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Open data
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Basic information
Entry | Database: PDB / ID: 3zd1 | ||||||
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Title | STRUCTURE OF THE TWO C-TERMINAL DOMAINS OF COMPLEMENT FACTOR H RELATED PROTEIN 2 | ||||||
![]() | COMPLEMENT FACTOR H-RELATED PROTEIN 2 | ||||||
![]() | IMMUNE SYSTEM / CFHR-2 / CFHR2 / FHR2 | ||||||
Function / homology | ![]() complement component C3b binding / complement activation / cytolysis by host of symbiont cells / negative regulation of protein binding / Regulation of Complement cascade / protein-containing complex / extracellular space / extracellular region / identical protein binding Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Caesar, J.J.E. / Goicoechea de Jorge, E. / Pickering, M.C. / Lea, S.M. | ||||||
![]() | ![]() Title: Dimerization of Complement Factor H-Related Proteins Modulates Complement Activation in Vivo. Authors: Goicoechea De Jorge, E. / Caesar, J.J.E. / Malik, T.H. / Patel, M. / Colledge, M. / Johnson, S. / Hakobyan, S. / Morgan, B.P. / Harris, C.L. / Pickering, M.C. / Lea, S.M. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 64.2 KB | Display | ![]() |
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PDB format | ![]() | 47.2 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Related structure data | ![]() 3zd2C ![]() 2g7iS C: citing same article ( S: Starting model for refinement |
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Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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1 | ![]()
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2 | ![]()
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS oper: (Code: given Matrix: (0.996773, -0.016503, -0.078563), Vector: |
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Components
#1: Protein | Mass: 14303.232 Da / Num. of mol.: 2 / Fragment: SCR DOMAINS 3 AND 4, RESIDUES 147-270 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() #2: Chemical | ChemComp-EDO / #3: Water | ChemComp-HOH / | |
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-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.23 Å3/Da / Density % sol: 44.96 % / Description: NONE |
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Crystal grow | Details: 30% (W/V) PEG 8000, 0.2M AMMONIUM SULPHATE |
-Data collection
Diffraction | Mean temperature: 120 K |
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Diffraction source | Source: ![]() ![]() ![]() |
Detector | Type: DECTRIS PILATUS 6M / Detector: PIXEL / Date: Dec 16, 2011 / Details: MIRRORS |
Radiation | Monochromator: SINGLE BOUNCE / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength: 0.9173 Å / Relative weight: 1 |
Reflection | Resolution: 2→95.47 Å / Num. obs: 16993 / % possible obs: 96.7 % / Observed criterion σ(I): 2 / Redundancy: 3.2 % / Biso Wilson estimate: 27.21 Å2 / Rmerge(I) obs: 0.05 / Net I/σ(I): 15.2 |
Reflection shell | Resolution: 2→2.05 Å / Redundancy: 2.6 % / Rmerge(I) obs: 0.26 / Mean I/σ(I) obs: 4 / % possible all: 86.8 |
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Processing
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Refinement | Method to determine structure: ![]() Starting model: PDB ENTRY 2G7I Resolution: 2→19.09 Å / Cor.coef. Fo:Fc: 0.9283 / Cor.coef. Fo:Fc free: 0.9205 / SU R Cruickshank DPI: 0.207 / Cross valid method: THROUGHOUT / σ(F): 0 / SU R Blow DPI: 0.213 / SU Rfree Blow DPI: 0.17 / SU Rfree Cruickshank DPI: 0.169
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Displacement parameters | Biso mean: 27.45 Å2
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Refine analyze | Luzzati coordinate error obs: 0.241 Å | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement step | Cycle: LAST / Resolution: 2→19.09 Å
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Refine LS restraints |
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LS refinement shell | Resolution: 2→2.12 Å / Total num. of bins used: 9
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