Entry | Database: PDB / ID: 3wx1 |
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Title | Mouse Cereblon thalidomide binding domain, selenomethionine derivative |
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Components | Protein cereblon |
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Keywords | METAL BINDING PROTEIN / Zinc Finger / E3 ubiquitin ligase |
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Function / homology | Function and homology information
negative regulation of large conductance calcium-activated potassium channel activity / negative regulation of monoatomic ion transmembrane transport / Cul4A-RING E3 ubiquitin ligase complex / locomotory exploration behavior / positive regulation of Wnt signaling pathway / negative regulation of protein-containing complex assembly / positive regulation of protein-containing complex assembly / proteasome-mediated ubiquitin-dependent protein catabolic process / transmembrane transporter binding / protein ubiquitination ...negative regulation of large conductance calcium-activated potassium channel activity / negative regulation of monoatomic ion transmembrane transport / Cul4A-RING E3 ubiquitin ligase complex / locomotory exploration behavior / positive regulation of Wnt signaling pathway / negative regulation of protein-containing complex assembly / positive regulation of protein-containing complex assembly / proteasome-mediated ubiquitin-dependent protein catabolic process / transmembrane transporter binding / protein ubiquitination / perinuclear region of cytoplasm / membrane / nucleus / metal ion binding / cytoplasmSimilarity search - Function Peptide methionine sulfoxide reductase. / Yippee/Mis18/Cereblon / Yippee zinc-binding/DNA-binding /Mis18, centromere assembly / Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A / CULT domain / CULT domain profile. / Lon protease, N-terminal domain superfamily / Lon N-terminal domain profile. / Lon protease, N-terminal domain / ATP-dependent protease La (LON) substrate-binding domain ...Peptide methionine sulfoxide reductase. / Yippee/Mis18/Cereblon / Yippee zinc-binding/DNA-binding /Mis18, centromere assembly / Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A / CULT domain / CULT domain profile. / Lon protease, N-terminal domain superfamily / Lon N-terminal domain profile. / Lon protease, N-terminal domain / ATP-dependent protease La (LON) substrate-binding domain / Found in ATP-dependent protease La (LON) / PUA-like superfamily / Beta Complex / Mainly BetaSimilarity search - Domain/homology |
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Biological species | ![](img/tx_mammal.gif) Mus musculus (house mouse) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MAD / Resolution: 1.93 Å |
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Authors | Mori, T. / Ito, T. / Hirano, Y. / Yamaguchi, Y. / Handa, H. / Hakoshima, T. |
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Citation | Journal: Nat.Struct.Mol.Biol. / Year: 2014 Title: Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs Authors: Chamberlain, P.P. / Lopez-Girona, A. / Miller, K. / Carmel, G. / Pagarigan, B. / Chie-Leon, B. / Rychak, E. / Corral, L.G. / Ren, Y.J. / Wang, M. / Riley, M. / Delker, S.L. / Ito, T. / Ando, ...Authors: Chamberlain, P.P. / Lopez-Girona, A. / Miller, K. / Carmel, G. / Pagarigan, B. / Chie-Leon, B. / Rychak, E. / Corral, L.G. / Ren, Y.J. / Wang, M. / Riley, M. / Delker, S.L. / Ito, T. / Ando, H. / Mori, T. / Hirano, Y. / Handa, H. / Hakoshima, T. / Daniel, T.O. / Cathers, B.E. |
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History | Deposition | Jul 10, 2014 | Deposition site: PDBJ / Processing site: PDBJ |
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Revision 1.0 | Aug 6, 2014 | Provider: repository / Type: Initial release |
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Revision 1.1 | Aug 27, 2014 | Group: Database references |
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Revision 1.2 | Sep 17, 2014 | Group: Database references |
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