- PDB-3wcy: Murine Ifnar1 in complex with interferon-beta -
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Basic information
Entry
Database: PDB / ID: 3wcy
Title
Murine Ifnar1 in complex with interferon-beta
Components
Interferon alpha/beta receptor 1
Interferon beta
Keywords
CYTOKINE RECEPTOR/CYTOKINE / Fibronectin Type III / Helical cytokine / Cytokine receptor / Interferon / CYTOKINE RECEPTOR-CYTOKINE complex
Function / homology
Function and homology information
negative regulation of Lewy body formation / type I interferon production / negative regulation of matrix metallopeptidase secretion / negative regulation of mononuclear cell migration / interferon receptor activity / type I interferon receptor activity / type I interferon binding / Regulation of IFNA/IFNB signaling / type I interferon receptor binding / negative regulation of immunoglobulin production ...negative regulation of Lewy body formation / type I interferon production / negative regulation of matrix metallopeptidase secretion / negative regulation of mononuclear cell migration / interferon receptor activity / type I interferon receptor activity / type I interferon binding / Regulation of IFNA/IFNB signaling / type I interferon receptor binding / negative regulation of immunoglobulin production / Interferon alpha/beta signaling / cellular response to interferon-alpha / natural killer cell activation involved in immune response / negative regulation of blood-brain barrier permeability / positive regulation of peptidyl-serine phosphorylation of STAT protein / negative regulation of neuroinflammatory response / negative regulation of cell adhesion molecule production / positive regulation of transforming growth factor beta production / T cell activation involved in immune response / macrophage activation involved in immune response / cellular response to dsRNA / cytokine receptor activity / type I interferon-mediated signaling pathway / response to exogenous dsRNA / B cell proliferation / negative regulation of osteoclast differentiation / plasma membrane => GO:0005886 / humoral immune response / negative regulation of type II interferon production / positive regulation of autophagy / regulation of peptidyl-tyrosine phosphorylation / T cell activation / positive regulation of interferon-beta production / B cell differentiation / cellular response to dexamethasone stimulus / positive regulation of interleukin-1 beta production / cytokine activity / cellular response to virus / cytokine-mediated signaling pathway / neuron cellular homeostasis / positive regulation of type II interferon production / late endosome / defense response to virus / adaptive immune response / response to lipopolysaccharide / membrane => GO:0016020 / lysosome / defense response to bacterium / negative regulation of cell population proliferation / positive regulation of DNA-templated transcription / extracellular space / extracellular region / plasma membrane Similarity search - Function
Interferon alpha/beta receptor 1 / Interferon alpha, beta and delta family signature. / Interferon alpha, beta and delta. / Interferon alpha/beta/delta / Interferon alpha/beta domain / Interferon/interleukin receptor domain / Interferon-alpha/beta receptor, fibronectin type III / Tissue factor / Growth Hormone; Chain: A; - #10 / Four-helical cytokine-like, core ...Interferon alpha/beta receptor 1 / Interferon alpha, beta and delta family signature. / Interferon alpha, beta and delta. / Interferon alpha/beta/delta / Interferon alpha/beta domain / Interferon/interleukin receptor domain / Interferon-alpha/beta receptor, fibronectin type III / Tissue factor / Growth Hormone; Chain: A; - #10 / Four-helical cytokine-like, core / Growth Hormone; Chain: A; / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Immunoglobulins / Immunoglobulin-like fold / Up-down Bundle / Immunoglobulin-like / Sandwich / Mainly Beta / Mainly Alpha Similarity search - Domain/homology
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