SIGNALING PROTEIN RECEPTOR / human / type I interferons / receptor chain / IFNAR1 / fibronectin type III / type I interferon receptor chain / extracellular space
Function / homology
Function and homology information
type I interferon receptor activity / type I interferon binding / JAK pathway signal transduction adaptor activity / cellular response to interferon-alpha / positive regulation of cellular respiration / type I interferon-mediated signaling pathway / cytokine binding / cell surface receptor signaling pathway via JAK-STAT / Regulation of IFNA/IFNB signaling / cellular response to interferon-beta ...type I interferon receptor activity / type I interferon binding / JAK pathway signal transduction adaptor activity / cellular response to interferon-alpha / positive regulation of cellular respiration / type I interferon-mediated signaling pathway / cytokine binding / cell surface receptor signaling pathway via JAK-STAT / Regulation of IFNA/IFNB signaling / cellular response to interferon-beta / response to virus / Evasion by RSV of host interferon responses / cellular response to virus / Interferon alpha/beta signaling / late endosome / Potential therapeutics for SARS / response to lipopolysaccharide / lysosome / SARS-CoV-2 activates/modulates innate and adaptive immune responses / plasma membrane Similarity search - Function
Interferon alpha/beta receptor 1 / Interferon/interleukin receptor domain / Interferon-alpha/beta receptor, fibronectin type III / Tissue factor / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Immunoglobulins / Immunoglobulin-like fold / Immunoglobulin-like ...Interferon alpha/beta receptor 1 / Interferon/interleukin receptor domain / Interferon-alpha/beta receptor, fibronectin type III / Tissue factor / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Immunoglobulins / Immunoglobulin-like fold / Immunoglobulin-like / Sandwich / Mainly Beta Similarity search - Domain/homology
Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelength
Wavelength: 0.9787 Å / Relative weight: 1
Reflection
Resolution: 1.9→19.486 Å / Num. obs: 55817 / % possible obs: 98.6 % / Redundancy: 7.6 % / Biso Wilson estimate: 33.2 Å2 / Rsym value: 5.3 / Net I/σ(I): 21.1
Reflection shell
Resolution: 1.9→2 Å / Redundancy: 7.6 % / Mean I/σ(I) obs: 3.4 / Rsym value: 74.8 / % possible all: 98.3
-
Processing
Software
Name
Classification
Blu-Ice
datacollection
autoSHARP
phasing
PHENIX
refinement
XDS
datareduction
XSCALE
datascaling
Refinement
Method to determine structure: SIRAS / Resolution: 1.9→19.486 Å / σ(F): 1.49 / Stereochemistry target values: ML Details: ANOMALOUS SCATTERER GROUP USED FOR ATOM SE WITH FP = -5.4570 AND FDP = 4.9472
Rfactor
Num. reflection
% reflection
Rfree
0.234
2784
4.99 %
Rwork
0.21
-
-
obs
-
55817
98.71 %
Solvent computation
Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL / Bsol: 58.27 Å2 / ksol: 0.4 e/Å3
Displacement parameters
Biso mean: 44.5 Å2
Baniso -1
Baniso -2
Baniso -3
1-
3.48 Å2
0 Å2
-0 Å2
2-
-
7.31 Å2
0 Å2
3-
-
-
-10.78 Å2
Refinement step
Cycle: LAST / Resolution: 1.9→19.486 Å
Protein
Nucleic acid
Ligand
Solvent
Total
Num. atoms
2152
0
14
145
2311
Refine LS restraints
Refine-ID
Type
Dev ideal
Number
X-RAY DIFFRACTION
f_bond_d
0.023
2269
X-RAY DIFFRACTION
f_angle_d
1.345
3093
X-RAY DIFFRACTION
f_dihedral_angle_d
15.731
801
X-RAY DIFFRACTION
f_chiral_restr
0.128
348
X-RAY DIFFRACTION
f_plane_restr
0.007
386
LS refinement shell
Resolution (Å)
Rfactor Rfree
Num. reflection Rfree
Rfactor Rwork
Num. reflection Rwork
Refine-ID
% reflection obs (%)
1.9-1.9678
0.3464
280
0.2945
5301
X-RAY DIFFRACTION
98
1.9678-2.0465
0.2816
275
0.2557
5278
X-RAY DIFFRACTION
98
2.0465-2.1396
0.2494
278
0.2248
5275
X-RAY DIFFRACTION
98
2.1396-2.2522
0.247
278
0.2227
5270
X-RAY DIFFRACTION
99
2.2522-2.3931
0.2852
282
0.2387
5352
X-RAY DIFFRACTION
99
2.3931-2.5775
0.2688
281
0.2426
5329
X-RAY DIFFRACTION
99
2.5775-2.8361
0.2595
277
0.226
5321
X-RAY DIFFRACTION
99
2.8361-3.2449
0.2259
283
0.2159
5340
X-RAY DIFFRACTION
100
3.2449-4.082
0.2314
279
0.1948
5373
X-RAY DIFFRACTION
100
4.082-19.4866
0.1952
271
0.1877
5194
X-RAY DIFFRACTION
97
Refinement TLS params.
Method: refined / Refine-ID: X-RAY DIFFRACTION
ID
L11 (°2)
L12 (°2)
L13 (°2)
L22 (°2)
L23 (°2)
L33 (°2)
S11 (Å °)
S12 (Å °)
S13 (Å °)
S21 (Å °)
S22 (Å °)
S23 (Å °)
S31 (Å °)
S32 (Å °)
S33 (Å °)
T11 (Å2)
T12 (Å2)
T13 (Å2)
T22 (Å2)
T23 (Å2)
T33 (Å2)
Origin x (Å)
Origin y (Å)
Origin z (Å)
1
0.6215
0.485
0.5718
0.8143
0.951
0.5794
-0.0359
0.2609
0.0245
0.0687
0.0004
0.0798
0.1966
0.0422
-0.0006
0.272
-0.0406
-0.0169
0.2881
-0.0253
0.2144
9.714
-12.3889
1.0721
2
1.0384
0.3197
0.0584
0.8465
0.9005
2.4949
0.0233
0.0685
-0.0499
0.1566
0.0529
0.0498
0.1953
0.2179
-0.0028
0.1627
-0.0026
-0.0057
0.1373
-0.0232
0.2093
-7.709
-29.337
-36.722
Refinement TLS group
ID
Refine-ID
Refine TLS-ID
Selection details
1
X-RAY DIFFRACTION
1
chainAandresid7:98
2
X-RAY DIFFRACTION
2
chainAandresid99:299
+
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