- PDB-3vut: Crystal structures of non-phosphorylated MAP2K4 -
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基本情報
登録情報
データベース: PDB / ID: 3vut
タイトル
Crystal structures of non-phosphorylated MAP2K4
要素
Dual specificity mitogen-activated protein kinase kinase 4
キーワード
TRANSFERASE / apo form / Kinase
機能・相同性
機能・相同性情報
smooth muscle cell apoptotic process / intrinsic apoptotic signaling pathway in response to hydrogen peroxide / cellular response to sorbitol / JUN kinase kinase activity / cell growth involved in cardiac muscle cell development / mitogen-activated protein kinase kinase / negative regulation of motor neuron apoptotic process / positive regulation of nitric-oxide synthase biosynthetic process / Fc-epsilon receptor signaling pathway / Uptake and function of anthrax toxins ...smooth muscle cell apoptotic process / intrinsic apoptotic signaling pathway in response to hydrogen peroxide / cellular response to sorbitol / JUN kinase kinase activity / cell growth involved in cardiac muscle cell development / mitogen-activated protein kinase kinase / negative regulation of motor neuron apoptotic process / positive regulation of nitric-oxide synthase biosynthetic process / Fc-epsilon receptor signaling pathway / Uptake and function of anthrax toxins / JNK cascade / dendrite cytoplasm / MAP3K8 (TPL2)-dependent MAPK1/3 activation / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / positive regulation of DNA replication / FCERI mediated MAPK activation / positive regulation of JNK cascade / response to wounding / cellular response to mechanical stimulus / MAPK cascade / cellular senescence / positive regulation of neuron apoptotic process / perikaryon / protein tyrosine kinase activity / Oxidative Stress Induced Senescence / molecular adaptor activity / protein kinase activity / positive regulation of protein phosphorylation / phosphorylation / axon / protein serine kinase activity / protein serine/threonine kinase activity / signal transduction / ATP binding / nucleus / cytosol 類似検索 - 分子機能
Helix Hairpins - #2120 / Helix Hairpins / Helix non-globular / Special / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. ...Helix Hairpins - #2120 / Helix Hairpins / Helix non-globular / Special / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性
Dual specificity mitogen-activated protein kinase kinase 4 類似検索 - 構成要素
構造決定の手法: 分子置換 / 解像度: 3.5→20 Å / Cor.coef. Fo:Fc: 0.847 / Cor.coef. Fo:Fc free: 0.773 / SU B: 46.99 / SU ML: 0.733 / 交差検証法: THROUGHOUT / σ(F): 0 / ESU R Free: 0.195 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD / 詳細: HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT
Rfactor
反射数
%反射
Selection details
Rfree
0.40666
447
4.9 %
RANDOM
Rwork
0.3312
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all
0.33471
8659
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obs
0.33471
8658
98.19 %
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溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.2 Å / 溶媒モデル: BABINET MODEL WITH MASK