Entry Database : PDB / ID : 3u1n Structure visualization Downloads & linksTitle Structure of the catalytic core of human SAMHD1 ComponentsSAM domain and HD domain-containing protein 1 Details Keywords HYDROLASE / HD-domain / deoxynucleotide triphosphohydrolaseFunction / homology Function and homology informationFunction Domain/homology Component
Nucleotide catabolism / Hydrolases; Acting on ester bonds; Triphosphoric-monoester hydrolases / deoxynucleoside triphosphate hydrolase activity / triphosphoric monoester hydrolase activity / dGTP binding / dATP catabolic process / dGTPase activity / tetraspanin-enriched microdomain / DNA strand resection involved in replication fork processing / deoxyribonucleotide catabolic process ... Nucleotide catabolism / Hydrolases; Acting on ester bonds; Triphosphoric-monoester hydrolases / deoxynucleoside triphosphate hydrolase activity / triphosphoric monoester hydrolase activity / dGTP binding / dATP catabolic process / dGTPase activity / tetraspanin-enriched microdomain / DNA strand resection involved in replication fork processing / deoxyribonucleotide catabolic process / dGTP catabolic process / negative regulation of type I interferon-mediated signaling pathway / regulation of innate immune response / somatic hypermutation of immunoglobulin genes / RNA nuclease activity / double-strand break repair via homologous recombination / Interferon alpha/beta signaling / site of double-strand break / single-stranded DNA binding / protein homotetramerization / defense response to virus / nucleic acid binding / immune response / innate immune response / DNA damage response / GTP binding / RNA binding / zinc ion binding / nucleoplasm / identical protein binding / nucleus / plasma membrane Similarity search - Function Alpha-Beta Plaits - #2760 / Hypothetical protein af1432 / Hypothetical protein af1432 / HD domain profile. / HD domain / HD domain / SAM domain (Sterile alpha motif) / SAM domain profile. / Metal dependent phosphohydrolases with conserved 'HD' motif. / Sterile alpha motif. ... Alpha-Beta Plaits - #2760 / Hypothetical protein af1432 / Hypothetical protein af1432 / HD domain profile. / HD domain / HD domain / SAM domain (Sterile alpha motif) / SAM domain profile. / Metal dependent phosphohydrolases with conserved 'HD' motif. / Sterile alpha motif. / HD/PDEase domain / Sterile alpha motif domain / Sterile alpha motif/pointed domain superfamily / Alpha-Beta Plaits / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / SAD / Resolution : 3.1 Å DetailsAuthors Goldstone, D.C. / Ennis-Adeniran, V. / Walker, P.A. / Haire, L.F. / Webb, M. / Taylor, I.A. CitationJournal : Nature / Year : 2011Title : HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolaseAuthors: Goldstone, D.C. / Ennis-Adeniran, V. / Hedden, J.J. / Groom, H.C. / Rice, G.I. / Christodoulou, E. / Walker, P.A. / Kelly, G. / Haire, L.F. / Yap, M.W. / de Carvalho, L.P. / Stoye, J.P. / ... Authors : Goldstone, D.C. / Ennis-Adeniran, V. / Hedden, J.J. / Groom, H.C. / Rice, G.I. / Christodoulou, E. / Walker, P.A. / Kelly, G. / Haire, L.F. / Yap, M.W. / de Carvalho, L.P. / Stoye, J.P. / Crow, Y.J. / Taylor, I.A. / Webb, M. History Deposition Sep 30, 2011 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Nov 16, 2011 Provider : repository / Type : Initial releaseRevision 1.1 Dec 14, 2011 Group : Database referencesRevision 1.2 Nov 12, 2014 Group : Structure summaryRevision 1.3 Jan 24, 2018 Group : Structure summary / Category : audit_author / Item : _audit_author.name
Show all Show less