Entry Database : PDB / ID : 3tvd Structure visualization Downloads & linksTitle Crystal Structure of Mouse RhoA-GTP complex ComponentsTransforming protein RhoA Details Keywords SIGNALING PROTEIN / Alpha helical / Protein_GTP complex / Helical protein / GTP binding protein / Regulates signal transduction pathway / GTP / Nil / MembraneFunction / homology Function and homology informationFunction Domain/homology Component
trabecula morphogenesis / EPHA-mediated growth cone collapse / PCP/CE pathway / RHO GTPases activate PKNs / SLIT2:ROBO1 increases RHOA activity / RHO GTPases Activate Rhotekin and Rhophilins / : / Sema4D mediated inhibition of cell attachment and migration / RHO GTPases Activate ROCKs / ERBB2 Regulates Cell Motility ... trabecula morphogenesis / EPHA-mediated growth cone collapse / PCP/CE pathway / RHO GTPases activate PKNs / SLIT2:ROBO1 increases RHOA activity / RHO GTPases Activate Rhotekin and Rhophilins / : / Sema4D mediated inhibition of cell attachment and migration / RHO GTPases Activate ROCKs / ERBB2 Regulates Cell Motility / RHO GTPases activate KTN1 / PI3K/AKT activation / PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases / Sema4D induced cell migration and growth-cone collapse / Ovarian tumor domain proteases / Axonal growth inhibition (RHOA activation) / Axonal growth stimulation / VEGFA-VEGFR2 Pathway / RHO GTPases Activate Formins / GPVI-mediated activation cascade / TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) / G alpha (12/13) signalling events / : / RHO GTPases activate CIT / : / regulation of actin polymerization or depolymerization / regulation of dendrite development / response to xenobiotic stimulus => GO:0009410 / alpha-beta T cell lineage commitment / mitotic cleavage furrow formation / regulation of modification of synaptic structure / positive regulation of lipase activity / endothelial tube lumen extension / skeletal muscle satellite cell migration / positive regulation of vascular associated smooth muscle contraction / angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure / cellular response to progesterone stimulus / Roundabout signaling pathway / negative regulation of intracellular steroid hormone receptor signaling pathway / regulation of neural precursor cell proliferation / cleavage furrow formation / EPHB-mediated forward signaling / regulation of modification of postsynaptic actin cytoskeleton / positive regulation of smooth muscle contraction / regulation of osteoblast proliferation / cortical cytoskeleton organization / forebrain radial glial cell differentiation / cell junction assembly / apical junction assembly / regulation of systemic arterial blood pressure by endothelin / negative regulation of cell migration involved in sprouting angiogenesis / cellular response to chemokine / negative regulation of cell size / G beta:gamma signalling through PI3Kgamma / beta selection / establishment of epithelial cell apical/basal polarity / negative regulation of oxidative phosphorylation / stress-activated protein kinase signaling cascade / apolipoprotein A-I-mediated signaling pathway / GTP metabolic process / positive regulation of podosome assembly / negative regulation of cell-substrate adhesion / positive regulation of alpha-beta T cell differentiation / ossification involved in bone maturation / odontogenesis / positive regulation of leukocyte adhesion to vascular endothelial cell / wound healing, spreading of cells / apical junction complex / Neutrophil degranulation / regulation of neuron projection development / negative chemotaxis / Rho GDP-dissociation inhibitor binding / myosin binding / positive regulation of actin filament polymerization / stress fiber assembly / androgen receptor signaling pathway / positive regulation of cytokinesis / cerebral cortex cell migration / cellular response to cytokine stimulus / regulation of calcium ion transport / positive regulation of cysteine-type endopeptidase activity involved in apoptotic process / cleavage furrow / Rho protein signal transduction / positive regulation of cell adhesion / negative regulation of neuron differentiation / mitotic spindle assembly / endothelial cell migration / positive regulation of T cell migration / response to amino acid / response to glucose / regulation of microtubule cytoskeleton organization / negative regulation of reactive oxygen species biosynthetic process / response to mechanical stimulus / negative regulation of canonical NF-kappaB signal transduction / cytoplasmic microtubule organization / response to glucocorticoid / skeletal muscle tissue development / positive regulation of vasoconstriction / extrinsic component of cytoplasmic side of plasma membrane / regulation of cell migration Similarity search - Function Small GTPase Rho / small GTPase Rho family profile. / Small GTPase / Ras family / Small GTP-binding protein domain / P-loop containing nucleotide triphosphate hydrolases / P-loop containing nucleoside triphosphate hydrolase / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution : 2.989 Å DetailsAuthors Swaminathan, K. / Pal, K. / Jobichen, C. CitationJournal : J.Struct.Funct.Genom. / Year : 2012Title : Crystal structure of mouse RhoA:GTPgammaS complex in a centered lattice.Authors : Jobichen, C. / Pal, K. / Swaminathan, K. History Deposition Sep 20, 2011 Deposition site : RCSB / Processing site : PDBJRevision 1.0 Oct 10, 2012 Provider : repository / Type : Initial releaseRevision 1.1 Jul 10, 2013 Group : Database referencesRevision 1.2 Nov 1, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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