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Yorodumi- PDB-3qnf: Crystal structure of the open state of human endoplasmic reticulu... -
+Open data
-Basic information
Entry | Database: PDB / ID: 3qnf | |||||||||
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Title | Crystal structure of the open state of human endoplasmic reticulum aminopeptidase 1 ERAP1 | |||||||||
Components | Endoplasmic reticulum aminopeptidase 1ERAP1 | |||||||||
Keywords | HYDROLASE / Structural Genomics Consortium / SGC / glycoprotein / metal-binding / metalloprotease / protease / adaptive immunity | |||||||||
Function / homology | Function and homology information interleukin-1, type II receptor binding / interleukin-6 receptor binding / Hydrolases; Acting on peptide bonds (peptidases); Aminopeptidases / metalloexopeptidase activity / antigen processing and presentation of peptide antigen via MHC class I / regulation of innate immune response / peptide catabolic process / fat cell differentiation / metalloaminopeptidase activity / membrane protein ectodomain proteolysis ...interleukin-1, type II receptor binding / interleukin-6 receptor binding / Hydrolases; Acting on peptide bonds (peptidases); Aminopeptidases / metalloexopeptidase activity / antigen processing and presentation of peptide antigen via MHC class I / regulation of innate immune response / peptide catabolic process / fat cell differentiation / metalloaminopeptidase activity / membrane protein ectodomain proteolysis / aminopeptidase activity / response to bacterium / Antigen Presentation: Folding, assembly and peptide loading of class I MHC / peptide binding / antigen processing and presentation of endogenous peptide antigen via MHC class I / regulation of blood pressure / positive regulation of angiogenesis / angiogenesis / endopeptidase activity / adaptive immune response / endoplasmic reticulum lumen / endoplasmic reticulum membrane / endoplasmic reticulum / proteolysis / extracellular space / extracellular exosome / zinc ion binding / extracellular region / membrane / cytosol / cytoplasm Similarity search - Function | |||||||||
Biological species | Homo sapiens (human) | |||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3 Å | |||||||||
Authors | Vollmar, M. / Kochan, G. / Krojer, T. / Harvey, D. / Chaikuad, A. / Allerston, C. / Muniz, J.R.C. / Raynor, J. / Ugochukwu, E. / Berridge, G. ...Vollmar, M. / Kochan, G. / Krojer, T. / Harvey, D. / Chaikuad, A. / Allerston, C. / Muniz, J.R.C. / Raynor, J. / Ugochukwu, E. / Berridge, G. / Wordsworth, B.P. / von Delft, F. / Bountra, C. / Arrowsmith, C.H. / Edwards, A. / Kavanagh, K. / Oppermann, U. / Structural Genomics Consortium (SGC) | |||||||||
Citation | Journal: Proc.Natl.Acad.Sci.USA / Year: 2011 Title: Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming. Authors: Kochan, G. / Krojer, T. / Harvey, D. / Fischer, R. / Chen, L. / Vollmar, M. / von Delft, F. / Kavanagh, K.L. / Brown, M.A. / Bowness, P. / Wordsworth, P. / Kessler, B.M. / Oppermann, U. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 3qnf.cif.gz | 465.4 KB | Display | PDBx/mmCIF format |
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PDB format | pdb3qnf.ent.gz | 364.7 KB | Display | PDB format |
PDBx/mmJSON format | 3qnf.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/qn/3qnf ftp://data.pdbj.org/pub/pdb/validation_reports/qn/3qnf | HTTPS FTP |
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-Related structure data
Related structure data | 2yd0C 2xdt C: citing same article (ref.) S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
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Noncrystallographic symmetry (NCS) | NCS domain:
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