Entry Database : PDB / ID : 5cxg Structure visualization Downloads & linksTitle Crystal structure of Mycobacterium tuberculosis KstR in complex with PEG ComponentsHTH-type transcriptional repressor KstR Details Keywords Transcription regulator / Transcriptional repressor / TetR family Transcriptional repressor / cholesterol catabolism / CoA thioester ligand / Structural Genomics / TB Structural Genomics Consortium / TBSGCFunction / homology Function and homology informationFunction Domain/homology Component
transcription cis-regulatory region binding / DNA-binding transcription factor activity / regulation of DNA-templated transcription / protein homodimerization activity / DNA binding Similarity search - Function HTH-type transcriptional repressor KstR, C-terminal / Tetracyclin repressor-like, C-terminal domain / Tetracycline Repressor, domain 2 / Tetracycline Repressor; domain 2 / Bacterial regulatory proteins, tetR family / DNA-binding HTH domain, TetR-type / TetR-type HTH domain profile. / Homeobox-like domain superfamily / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Mycobacterium tuberculosis (bacteria)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.1001 Å DetailsAuthors Ho, N.A.T. / Dawes, S. / Kendall, S. / Baker, E.N. / Lott, J.S. / TB Structural Genomics Consortium (TBSGC) Funding support New Zealand, 1items Details Hide detailsOrganization Grant number Country Health Research Council (HRC) 12/1111 New Zealand
CitationJournal : J.Biol.Chem. / Year : 2016Title : The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.Authors : Ho, N.A. / Dawes, S.S. / Crowe, A.M. / Casabon, I. / Gao, C. / Kendall, S.L. / Baker, E.N. / Eltis, L.D. / Lott, J.S. History Deposition Jul 28, 2015 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Feb 17, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Feb 24, 2016 Group : Database referencesRevision 1.2 Apr 20, 2016 Group : Database referencesRevision 1.3 Nov 1, 2017 Group : Author supporting evidence / Data collection ... Author supporting evidence / Data collection / Database references / Derived calculations Category : citation / diffrn_source ... citation / diffrn_source / pdbx_struct_assembly_auth_evidence / pdbx_struct_oper_list Item : _citation.journal_id_CSD / _diffrn_source.pdbx_synchrotron_site / _pdbx_struct_oper_list.symmetry_operationRevision 1.4 Jan 1, 2020 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.5 Sep 27, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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