Entry | Database: PDB / ID: 3pcs |
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Title | Structure of EspG-PAK2 autoinhibitory Ialpha3 helix complex |
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Components | - EspG
- Serine/threonine-protein kinase PAK 2
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Keywords | PROTEIN TRANSPORT/TRANSFERASE / BACTERIAL EFFECTOR / KINASE / AUTOINHIBITORY IALPHA3 HELIX / PROTEIN TRANSPORT-TRANSFERASE complex |
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Function / homology | Function and homology information
Regulation of PAK-2p34 activity by PS-GAP/RHG10 / negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis / virus-mediated perturbation of host defense response => GO:0019049 / signal transduction => GO:0007165 / small GTPase binding => GO:0031267 / protein localization to cell-cell junction / Stimulation of the cell death response by PAK-2p34 / dendritic spine development / bicellular tight junction assembly / adherens junction assembly ...Regulation of PAK-2p34 activity by PS-GAP/RHG10 / negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis / virus-mediated perturbation of host defense response => GO:0019049 / signal transduction => GO:0007165 / small GTPase binding => GO:0031267 / protein localization to cell-cell junction / Stimulation of the cell death response by PAK-2p34 / dendritic spine development / bicellular tight junction assembly / adherens junction assembly / interleukin-12-mediated signaling pathway / Nef and signal transduction / positive regulation of extrinsic apoptotic signaling pathway / stress-activated protein kinase signaling cascade / Activation of RAC1 / regulation of growth / CD28 dependent Vav1 pathway / Ephrin signaling / negative regulation of stress fiber assembly / regulation of axonogenesis / activation of protein kinase activity / protein tyrosine kinase activator activity / regulation of cytoskeleton organization / RHO GTPases activate PAKs / Fc-epsilon receptor signaling pathway / stimulatory C-type lectin receptor signaling pathway / Sema3A PAK dependent Axon repulsion / cellular response to organic cyclic compound / Generation of second messenger molecules / Smooth Muscle Contraction / vascular endothelial growth factor receptor signaling pathway / T cell costimulation / Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation / CD209 (DC-SIGN) signaling / Regulation of activated PAK-2p34 by proteasome mediated degradation / VEGFR2 mediated vascular permeability / FCERI mediated MAPK activation / negative regulation of protein kinase activity / MAPK6/MAPK4 signaling / small GTPase binding / VEGFA-VEGFR2 Pathway / positive regulation of peptidyl-tyrosine phosphorylation / cell-cell junction / T cell receptor signaling pathway / peptidyl-serine phosphorylation / protein autophosphorylation / postsynaptic density / non-specific serine/threonine protein kinase / protein kinase activity / cadherin binding / phosphorylation / cysteine-type endopeptidase activity / protein phosphorylation / protein serine/threonine kinase activity / glutamatergic synapse / apoptotic process / negative regulation of apoptotic process / protein kinase binding / perinuclear region of cytoplasm / signal transduction / ATP binding / identical protein binding / nucleus / plasma membrane / cytoplasm / cytosolSimilarity search - Function p21-activated kinase 2, catalytic domain / Serine/threonine-protein kinase PAK2 / EspG protein, N-terminal domain / Cysteine protease, VirA/EspG / Cysteine protease, VirA/EspG, N-terminal / EspG protein / p21 activated kinase binding domain / CRIB domain superfamily / P21-Rho-binding domain / CRIB domain profile. ...p21-activated kinase 2, catalytic domain / Serine/threonine-protein kinase PAK2 / EspG protein, N-terminal domain / Cysteine protease, VirA/EspG / Cysteine protease, VirA/EspG, N-terminal / EspG protein / p21 activated kinase binding domain / CRIB domain superfamily / P21-Rho-binding domain / CRIB domain profile. / P21-Rho-binding domain / CRIB domain / Nuclear Transport Factor 2; Chain: A, / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Roll / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Alpha BetaSimilarity search - Domain/homology |
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Biological species | ![](img/tx_bacteria.gif) Escherichia coli (E. coli)
Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 2.86 Å |
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Authors | Tomchick, D.R. / Alto, N.M. / Selyunin, A.S. |
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Citation | Journal: Nature / Year: 2011 Title: The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold. Authors: Selyunin, A.S. / Sutton, S.E. / Weigele, B.A. / Reddick, L.E. / Orchard, R.C. / Bresson, S.M. / Tomchick, D.R. / Alto, N.M. |
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History | Deposition | Oct 21, 2010 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Jan 5, 2011 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jul 13, 2011 | Group: Source and taxonomy / Version format compliance |
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Revision 1.2 | Nov 8, 2017 | Group: Refinement description / Category: software / Item: _software.name |
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Revision 1.3 | Sep 6, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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