登録情報 | データベース: PDB / ID: 3mtt |
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タイトル | Crystal structure of iSH2 domain of human p85beta, Northeast Structural Genomics Consortium Target HR5531C |
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要素 | Phosphatidylinositol 3-kinase regulatory subunit beta |
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キーワード | SIGNALING PROTEIN / PROTEIN BINDING / PI3-kinase subunit p85-beta / inter-SH2 domain / Structural Genomics / PSI-2 / Protein Structure Initiative / Northeast Structural Genomics Consortium / NESG |
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機能・相同性 | 機能・相同性情報
IRS-mediated signalling / regulation of actin filament polymerization / 1-phosphatidylinositol-3-kinase regulator activity / phosphatidylinositol 3-kinase regulatory subunit binding / RHOF GTPase cycle / regulation of stress fiber assembly / RHOD GTPase cycle / phosphatidylinositol 3-kinase complex, class IA / phosphatidylinositol 3-kinase complex / Nephrin family interactions ...IRS-mediated signalling / regulation of actin filament polymerization / 1-phosphatidylinositol-3-kinase regulator activity / phosphatidylinositol 3-kinase regulatory subunit binding / RHOF GTPase cycle / regulation of stress fiber assembly / RHOD GTPase cycle / phosphatidylinositol 3-kinase complex, class IA / phosphatidylinositol 3-kinase complex / Nephrin family interactions / Signaling by LTK in cancer / RND1 GTPase cycle / Costimulation by the CD28 family / Signaling by LTK / RND2 GTPase cycle / PI3K/AKT activation / RND3 GTPase cycle / negative regulation of MAPK cascade / Signaling by ALK / RHOB GTPase cycle / RHOJ GTPase cycle / intracellular glucose homeostasis / CD28 dependent PI3K/Akt signaling / Synthesis of PIPs at the plasma membrane / phosphatidylinositol phosphate biosynthetic process / CDC42 GTPase cycle / RHOU GTPase cycle / RET signaling / positive regulation of cell adhesion / T cell differentiation / Interleukin-3, Interleukin-5 and GM-CSF signaling / PI3K Cascade / RHOA GTPase cycle / RAC2 GTPase cycle / RAC3 GTPase cycle / regulation of protein localization to plasma membrane / Role of phospholipids in phagocytosis / Role of LAT2/NTAL/LAB on calcium mobilization / Interleukin receptor SHC signaling / Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants / Signaling by PDGFRA extracellular domain mutants / Tie2 Signaling / GPVI-mediated activation cascade / RAC1 GTPase cycle / phosphatidylinositol 3-kinase/protein kinase B signal transduction / phosphotyrosine residue binding / Interleukin-7 signaling / Downstream signal transduction / response to endoplasmic reticulum stress / B cell differentiation / Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants / regulation of autophagy / Regulation of signaling by CBL / Signaling by SCF-KIT / cellular response to insulin stimulus / receptor tyrosine kinase binding / Constitutive Signaling by Aberrant PI3K in Cancer / VEGFA-VEGFR2 Pathway / positive regulation of protein import into nucleus / PIP3 activates AKT signaling / Signaling by ALK fusions and activated point mutants / protein transport / Downstream TCR signaling / insulin receptor signaling pathway / DAP12 signaling / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / RAF/MAP kinase cascade / protein phosphatase binding / G alpha (q) signalling events / Extra-nuclear estrogen signaling / immune response / protein heterodimerization activity / focal adhesion / positive regulation of transcription by RNA polymerase II / nucleus / cytosol類似検索 - 分子機能 Phosphatidylinositol 3-kinase regulatory subunit beta, SH3 domain / Helix Hairpins - #1490 / PI3K p85 subunit, C-terminal SH2 domain / PI3K regulatory subunit p85-related , inter-SH2 domain / PI3K p85 subunit, N-terminal SH2 domain / Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain / Rho GTPase-activating protein domain / RhoGAP domain / Rho GTPase-activating proteins domain profile. / GTPase-activator protein for Rho-like GTPases ...Phosphatidylinositol 3-kinase regulatory subunit beta, SH3 domain / Helix Hairpins - #1490 / PI3K p85 subunit, C-terminal SH2 domain / PI3K regulatory subunit p85-related , inter-SH2 domain / PI3K p85 subunit, N-terminal SH2 domain / Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain / Rho GTPase-activating protein domain / RhoGAP domain / Rho GTPase-activating proteins domain profile. / GTPase-activator protein for Rho-like GTPases / Rho GTPase activation protein / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / Src homology 3 domains / SH2 domain superfamily / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Helix Hairpins / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Phosphatidylinositol 3-kinase regulatory subunit beta類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.3 Å |
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データ登録者 | Guan, R. / Schauder, C. / Ma, L.C. / Krug, R.M. / Montelione, G.T. / Northeast Structural Genomics Consortium (NESG) |
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引用 | ジャーナル: Acta Crystallogr.,Sect.F / 年: 2010 タイトル: Structure of the iSH2 domain of human phosphatidylinositol 3-kinase p85beta subunit reveals conformational plasticity in the interhelical turn region 著者: Schauder, C. / Ma, L.C. / Krug, R.M. / Montelione, G.T. / Guan, R. |
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履歴 | 登録 | 2010年4月30日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2010年5月19日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2023年9月6日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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