- PDB-3j1v: A refined model of the prototypical Salmonella typhimurium T3SS b... -
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基本情報
登録情報
データベース: PDB / ID: 3j1v
タイトル
A refined model of the prototypical Salmonella typhimurium T3SS basal body reveals the molecular basis for its assembly
要素
Protein InvG
キーワード
CELL INVASION / T3SS / Secretin
機能・相同性
機能・相同性情報
type III protein secretion system complex / type II protein secretion system complex / protein secretion by the type III secretion system / protein secretion / cell outer membrane / identical protein binding 類似検索 - 分子機能
: / SPI-1 type 3 secretion system secretin, N0 domain / Type III secretion system outer membrane pore YscC/HrcC / : / Bacterial type II secretion system protein D signature. / Type II secretion system protein GspD, conserved site / NolW-like / Bacterial type II/III secretion system short domain / NolW-like superfamily / Type II/III secretion system / Bacterial type II and III secretion system protein 類似検索 - ドメイン・相同性
SPI-1 type 3 secretion system secretin 類似検索 - 構成要素
ジャーナル: Science / 年: 2011 タイトル: Three-dimensional model of Salmonella's needle complex at subnanometer resolution. 著者: Oliver Schraidt / Thomas C Marlovits / 要旨: Type III secretion systems (T3SSs) are essential virulence factors used by many Gram-negative bacteria to inject proteins that make eukaryotic host cells accessible to invasion. The T3SS core ...Type III secretion systems (T3SSs) are essential virulence factors used by many Gram-negative bacteria to inject proteins that make eukaryotic host cells accessible to invasion. The T3SS core structure, the needle complex (NC), is a ~3.5 megadalton-sized, oligomeric, membrane-embedded complex. Analyzing cryo-electron microscopy images of top views of NCs or NC substructures from Salmonella typhimurium revealed a 24-fold symmetry for the inner rings and a 15-fold symmetry for the outer rings, giving an overall C3 symmetry. Local refinement and averaging showed the organization of the central core and allowed us to reconstruct a subnanometer composite structure of the NC, which together with confident docking of atomic structures reveal insights into its overall organization and structural requirements during assembly.
THIS ENTRY 3J1V CONTAINS A STRUCTURAL MODEL FIT TO AN ELECTRON MICROSCOPY MAP (EMD-1875) DETERMINED ...THIS ENTRY 3J1V CONTAINS A STRUCTURAL MODEL FIT TO AN ELECTRON MICROSCOPY MAP (EMD-1875) DETERMINED ORIGINALLY BY AUTHORS: O.SCHRAIDT, T.C.MARLOVITS
A: Protein InvG B: Protein InvG C: Protein InvG D: Protein InvG E: Protein InvG F: Protein InvG G: Protein InvG H: Protein InvG I: Protein InvG J: Protein InvG K: Protein InvG L: Protein InvG M: Protein InvG N: Protein InvG O: Protein InvG