登録情報 | データベース: PDB / ID: 3hc8 |
---|
タイトル | Investigation of Aminopyridiopyrazinones as PDE5 Inhibitors: Evaluation of Modifications to the Central Ring System. |
---|
要素 | cGMP-specific 3',5'-cyclic phosphodiesterase,cAMP-specific 3',5'-cyclic phosphodiesterase 4A |
---|
キーワード | HYDROLASE / PDE5 / PDE-5 / inhibition / Alternative splicing / cAMP / Phosphoprotein / Polymorphism Allosteric enzyme / cGMP / cGMP-binding / Magnesium / Metal-binding / Nucleotide-binding / Zinc |
---|
機能・相同性 | 機能・相同性情報
positive regulation of oocyte development / 3',5'-cyclic-GMP phosphodiesterase / regulation of nitric oxide mediated signal transduction / negative regulation of cardiac muscle contraction / 3',5'-cyclic-AMP phosphodiesterase / regulation of protein kinase A signaling / regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway / oocyte development / RHOBTB1 GTPase cycle / relaxation of cardiac muscle ...positive regulation of oocyte development / 3',5'-cyclic-GMP phosphodiesterase / regulation of nitric oxide mediated signal transduction / negative regulation of cardiac muscle contraction / 3',5'-cyclic-AMP phosphodiesterase / regulation of protein kinase A signaling / regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway / oocyte development / RHOBTB1 GTPase cycle / relaxation of cardiac muscle / extrinsic component of membrane / positive regulation of cardiac muscle hypertrophy / cGMP catabolic process / cGMP effects / cAMP catabolic process / 3',5'-cyclic-nucleotide phosphodiesterase activity / cGMP binding / DARPP-32 events / Smooth Muscle Contraction / 3',5'-cyclic-GMP phosphodiesterase activity / 3',5'-cyclic-AMP phosphodiesterase activity / T cell proliferation / negative regulation of T cell proliferation / cAMP binding / cAMP-mediated signaling / ruffle membrane / sensory perception of smell / cellular response to xenobiotic stimulus / G alpha (s) signalling events / G protein-coupled receptor signaling pathway / perinuclear region of cytoplasm / signal transduction / nucleoplasm / membrane / nucleus / metal ion binding / plasma membrane / cytosol類似検索 - 分子機能 Phosphodiesterase 4 upstream conserved regions (UCR) / Phosphodiesterase 4 upstream conserved regions (UCR) / Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase / GAF domain / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase, conserved site / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily / 3'5'-cyclic nucleotide phosphodiesterase ...Phosphodiesterase 4 upstream conserved regions (UCR) / Phosphodiesterase 4 upstream conserved regions (UCR) / Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase / GAF domain / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase, conserved site / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase domain signature. / 3'5'-cyclic nucleotide phosphodiesterase domain profile. / Domain present in phytochromes and cGMP-specific phosphodiesterases. / GAF domain / GAF-like domain superfamily / Metal dependent phosphohydrolases with conserved 'HD' motif. / HD/PDEase domain / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Chem-PD4 / cGMP-specific 3',5'-cyclic phosphodiesterase / 3',5'-cyclic-AMP phosphodiesterase 4A類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / 分子置換 / 解像度: 1.79 Å |
---|
データ登録者 | Hughes, R.O. / Stallings, W.C. / Cubbage, J.W. / Williams, J.M. |
---|
引用 | ジャーナル: Bioorg.Med.Chem.Lett. / 年: 2009 タイトル: Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system. 著者: Hughes, R.O. / Walker, J.K. / Cubbage, J.W. / Fobian, Y.M. / Rogier, D.J. / Heasley, S.E. / Blevis-Bal, R.M. / Benson, A.G. / Owen, D.R. / Jacobsen, E.J. / Freskos, J.N. / Molyneaux, J.M. / ...著者: Hughes, R.O. / Walker, J.K. / Cubbage, J.W. / Fobian, Y.M. / Rogier, D.J. / Heasley, S.E. / Blevis-Bal, R.M. / Benson, A.G. / Owen, D.R. / Jacobsen, E.J. / Freskos, J.N. / Molyneaux, J.M. / Brown, D.L. / Stallings, W.C. / Acker, B.A. / Maddux, T.M. / Tollefson, M.B. / Williams, J.M. / Moon, J.B. / Mischke, B.V. / Rumsey, J.M. / Zheng, Y. / Macinnes, A. / Bond, B.R. / Yu, Y. |
---|
履歴 | 登録 | 2009年5月5日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2009年7月7日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2011年7月13日 | Group: Version format compliance |
---|
改定 1.2 | 2017年6月21日 | Group: Advisory / Database references ...Advisory / Database references / Source and taxonomy / Structure summary カテゴリ: entity / entity_name_com ...entity / entity_name_com / entity_src_gen / pdbx_distant_solvent_atoms / struct / struct_ref / struct_ref_seq / struct_ref_seq_dif Item: _entity.pdbx_description / _entity.pdbx_ec ..._entity.pdbx_description / _entity.pdbx_ec / _entity.pdbx_fragment / _entity.pdbx_mutation / _entity_name_com.name / _struct.pdbx_descriptor / _struct_ref.db_code / _struct_ref.pdbx_align_begin / _struct_ref.pdbx_db_accession / _struct_ref.pdbx_db_isoform / _struct_ref_seq.db_align_beg / _struct_ref_seq.db_align_end / _struct_ref_seq.pdbx_db_accession / _struct_ref_seq.pdbx_seq_align_end_ins_code / _struct_ref_seq.seq_align_end / _struct_ref_seq_dif.details |
---|
改定 1.3 | 2017年11月1日 | Group: Refinement description / カテゴリ: software |
---|
改定 1.4 | 2018年1月24日 | Group: Structure summary / カテゴリ: audit_author / Item: _audit_author.name |
---|
改定 1.5 | 2023年7月26日 | Group: Database references / Derived calculations カテゴリ: citation / database_2 ...citation / database_2 / pdbx_struct_conn_angle / struct_conn / struct_site Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
---|
改定 1.6 | 2024年5月22日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond |
---|
|
---|