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-Structure paper
Title | Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 19, Page 4092-4096, Year 2009 |
Publish date | May 5, 2009 (structure data deposition date) |
Authors | Hughes, R.O. / Walker, J.K. / Cubbage, J.W. / Fobian, Y.M. / Rogier, D.J. / Heasley, S.E. / Blevis-Bal, R.M. / Benson, A.G. / Owen, D.R. / Jacobsen, E.J. ...Hughes, R.O. / Walker, J.K. / Cubbage, J.W. / Fobian, Y.M. / Rogier, D.J. / Heasley, S.E. / Blevis-Bal, R.M. / Benson, A.G. / Owen, D.R. / Jacobsen, E.J. / Freskos, J.N. / Molyneaux, J.M. / Brown, D.L. / Stallings, W.C. / Acker, B.A. / Maddux, T.M. / Tollefson, M.B. / Williams, J.M. / Moon, J.B. / Mischke, B.V. / Rumsey, J.M. / Zheng, Y. / Macinnes, A. / Bond, B.R. / Yu, Y. |
External links | Bioorg. Med. Chem. Lett. / PubMed:19539468 |
Methods | X-ray diffraction |
Resolution | 1.79 Å |
Structure data | PDB-3hc8: |
Chemicals | ChemComp-PD4: ChemComp-ZN: ChemComp-MG: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / PDE5 / PDE-5 / inhibition / Alternative splicing / cAMP / Phosphoprotein / Polymorphism Allosteric enzyme / cGMP / cGMP-binding / Magnesium / Metal-binding / Nucleotide-binding / Zinc |