Entry Database : PDB / ID : 3evu Structure visualization Downloads & linksTitle Crystal structure of Calcium bound dimeric GCAMP2 ComponentsMyosin light chain kinase, Green fluorescent protein, Calmodulin-1 chimera Details Keywords SIGNALING PROTEIN / GCAMP2 / calcium sensor / GFP / Calmodulin / M13Function / homology Function and homology informationFunction Domain/homology Component
tonic smooth muscle contraction / myosin-light-chain kinase / myosin light chain kinase activity / muscle structure development / establishment of protein localization to mitochondrial membrane / type 3 metabotropic glutamate receptor binding / establishment of protein localization to membrane / presynaptic cytosol / regulation of synaptic vesicle endocytosis / regulation of synaptic vesicle exocytosis ... tonic smooth muscle contraction / myosin-light-chain kinase / myosin light chain kinase activity / muscle structure development / establishment of protein localization to mitochondrial membrane / type 3 metabotropic glutamate receptor binding / establishment of protein localization to membrane / presynaptic cytosol / regulation of synaptic vesicle endocytosis / regulation of synaptic vesicle exocytosis / organelle localization by membrane tethering / postsynaptic cytosol / mitochondrion-endoplasmic reticulum membrane tethering / autophagosome membrane docking / regulation of cardiac muscle cell action potential / nitric-oxide synthase binding / negative regulation of ryanodine-sensitive calcium-release channel activity / protein phosphatase activator activity / cleavage furrow / adenylate cyclase binding / catalytic complex / detection of calcium ion / regulation of cardiac muscle contraction / calcium channel regulator activity / regulation of ryanodine-sensitive calcium-release channel activity / cellular response to interferon-beta / calcium channel inhibitor activity / phosphatidylinositol 3-kinase binding / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / stress fiber / : / titin binding / voltage-gated potassium channel complex / sperm midpiece / calcium channel complex / response to amphetamine / adenylate cyclase activator activity / nitric-oxide synthase regulator activity / regulation of heart rate / sarcomere / protein serine/threonine kinase activator activity / regulation of cytokinesis / spindle microtubule / positive regulation of receptor signaling pathway via JAK-STAT / response to calcium ion / Schaffer collateral - CA1 synapse / cellular response to type II interferon / G2/M transition of mitotic cell cycle / spindle pole / calcium-dependent protein binding / serine-type endopeptidase inhibitor activity / lamellipodium / myelin sheath / growth cone / transmembrane transporter binding / calmodulin binding / protein domain specific binding / centrosome / calcium ion binding / protein kinase binding / protein-containing complex / mitochondrion / extracellular space / nucleoplasm / ATP binding / metal ion binding / cytoplasm / cytosol Similarity search - Function Myosin Light Chain Kinase 1, Kinase domain / Unstructured linker between I-set domains 2 and 3 on MYLCK / : / : / Green Fluorescent Protein / Green fluorescent protein / Serpin, conserved site / Serpins signature. / Serpin superfamily, domain 2 / Serpin family ... Myosin Light Chain Kinase 1, Kinase domain / Unstructured linker between I-set domains 2 and 3 on MYLCK / : / : / Green Fluorescent Protein / Green fluorescent protein / Serpin, conserved site / Serpins signature. / Serpin superfamily, domain 2 / Serpin family / Immunoglobulin I-set / Serpin domain / Serpin superfamily / Serpin superfamily, domain 1 / Serpin (serine protease inhibitor) / SERine Proteinase INhibitors / Immunoglobulin I-set domain / EF-hand / Recoverin; domain 1 / Fibronectin type III domain / Fibronectin type 3 domain / EF-hand domain pair / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair / Immunoglobulin subtype / Immunoglobulin / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Immunoglobulin-like fold / Protein kinase-like domain superfamily / Beta Barrel / Orthogonal Bundle / Mainly Beta / Mainly Alpha Similarity search - Domain/homologyBiological species Aequorea victoria (jellyfish)Gallus gallus (chicken)Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / SYNCHROTRON / Resolution : 1.75 Å DetailsAuthors Wang, Q. / Shui, B. / Kotlikoff, M.I. / Sondermann, H. CitationJournal : Structure / Year : 2008Title : Structural Basis for Calcium Sensing by GCaMP2.Authors : Wang, Q. / Shui, B. / Kotlikoff, M.I. / Sondermann, H. History Deposition Oct 13, 2008 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Dec 9, 2008 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Version format complianceRevision 1.2 Jul 26, 2017 Group : Advisory / Data collection ... Advisory / Data collection / Database references / Refinement description / Source and taxonomy / Structure summary Category : diffrn_radiation_wavelength / diffrn_source ... diffrn_radiation_wavelength / diffrn_source / entity / entity_name_com / entity_src_gen / pdbx_distant_solvent_atoms / software / struct / struct_ref / struct_ref_seq / struct_ref_seq_dif Item : _diffrn_radiation_wavelength.wavelength / _diffrn_source.pdbx_wavelength_list ... _diffrn_radiation_wavelength.wavelength / _diffrn_source.pdbx_wavelength_list / _entity.pdbx_description / _entity.pdbx_ec / _entity.pdbx_fragment / _struct.title / _struct_ref.db_code / _struct_ref.pdbx_align_begin / _struct_ref.pdbx_db_accession / _struct_ref.pdbx_seq_one_letter_code / _struct_ref_seq.db_align_beg / _struct_ref_seq.db_align_end / _struct_ref_seq.pdbx_auth_seq_align_beg / _struct_ref_seq.pdbx_db_accession / _struct_ref_seq.seq_align_beg Revision 1.3 Dec 27, 2023 Group : Data collection / Database references / Derived calculationsCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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