登録情報 | データベース: PDB / ID: 3evs |
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タイトル | Crystal structure of the GDF-5:BMP receptor IB complex. |
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要素 | - Bone morphogenetic protein receptor type-1B
- Growth/differentiation factor 5
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キーワード | CYTOKINE/Transferase Receptor / ligand-receptor complex / cystin-knot ligand / three-finger toxn fold (receptor) / Cleavage on pair of basic residues / Cytokine / Disease mutation / Dwarfism / Glycoprotein / Growth factor / Secreted / ATP-binding / Kinase / Magnesium / Manganese / Membrane / Metal-binding / Nucleotide-binding / Receptor / Serine/threonine-protein kinase / Transferase / Transmembrane / CYTOKINE-Transferase Receptor COMPLEX |
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機能・相同性 | 機能・相同性情報
ossification involved in bone remodeling / Signaling by BMP / ovarian cumulus expansion / negative regulation of chondrocyte proliferation / forelimb morphogenesis / chondrocyte development / estrogen biosynthetic process / positive regulation of extrinsic apoptotic signaling pathway via death domain receptors / BMP binding / proteoglycan biosynthetic process ...ossification involved in bone remodeling / Signaling by BMP / ovarian cumulus expansion / negative regulation of chondrocyte proliferation / forelimb morphogenesis / chondrocyte development / estrogen biosynthetic process / positive regulation of extrinsic apoptotic signaling pathway via death domain receptors / BMP binding / proteoglycan biosynthetic process / chondroblast differentiation / hindlimb morphogenesis / positive regulation of cartilage development / negative regulation of mesenchymal cell apoptotic process / endochondral bone morphogenesis / transforming growth factor beta receptor activity / positive regulation of chondrocyte differentiation / mesenchymal cell apoptotic process / limb morphogenesis / transforming growth factor beta receptor activity, type I / eye development / receptor protein serine/threonine kinase / transmembrane receptor protein serine/threonine kinase activity / cellular response to BMP stimulus / positive regulation of BMP signaling pathway / camera-type eye development / dorsal/ventral pattern formation / negative regulation of chondrocyte differentiation / embryonic limb morphogenesis / ovulation cycle / Molecules associated with elastic fibres / cell surface receptor protein serine/threonine kinase signaling pathway / cartilage condensation / retinal ganglion cell axon guidance / SMAD binding / positive regulation of SMAD protein signal transduction / regulation of multicellular organism growth / chondrocyte differentiation / BMP signaling pathway / positive regulation of osteoblast differentiation / positive regulation of bone mineralization / response to mechanical stimulus / positive regulation of neuron differentiation / transforming growth factor beta receptor signaling pathway / skeletal system development / cytokine activity / positive regulation of cell differentiation / growth factor activity / cellular response to growth factor stimulus / negative regulation of epithelial cell proliferation / cell-cell signaling / retina development in camera-type eye / negative regulation of neuron apoptotic process / membrane => GO:0016020 / cell differentiation / receptor complex / inflammatory response / protein phosphorylation / protein serine/threonine kinase activity / neuronal cell body / dendrite / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular region / ATP binding / identical protein binding / metal ion binding / plasma membrane類似検索 - 分子機能 TGF-beta, propeptide / TGF-beta propeptide / Transforming growth factor beta, conserved site / TGF-beta family signature. / Transforming growth factor-beta-related / GS domain / Transforming growth factor beta type I GS-motif / GS domain profile. / GS motif / Transforming growth factor-beta (TGF-beta) family ...TGF-beta, propeptide / TGF-beta propeptide / Transforming growth factor beta, conserved site / TGF-beta family signature. / Transforming growth factor-beta-related / GS domain / Transforming growth factor beta type I GS-motif / GS domain profile. / GS motif / Transforming growth factor-beta (TGF-beta) family / Activin types I and II receptor domain / Activin types I and II receptor domain / Transforming growth factor-beta, C-terminal / Transforming growth factor beta like domain / TGF-beta family profile. / Cystine Knot Cytokines, subunit B / Cystine-knot cytokines / CD59 / CD59 / Ser/Thr protein kinase, TGFB receptor / Cystine-knot cytokine / Ribbon / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Mainly Beta類似検索 - ドメイン・相同性 Bone morphogenetic protein receptor type-1B / Growth/differentiation factor 5類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト)
![](img/tx_mammal.gif) Mus musculus (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / 多波長異常分散 / 解像度: 2.1 Å |
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データ登録者 | Kotzsch, A. / Mueller, T.D. |
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引用 | ジャーナル: Embo J. / 年: 2009 タイトル: Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity. 著者: Kotzsch, A. / Nickel, J. / Seher, A. / Sebald, W. / Muller, T.D. |
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履歴 | 登録 | 2008年10月13日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2009年3月10日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Advisory / Version format compliance |
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改定 1.2 | 2023年12月27日 | Group: Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details |
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