登録情報 | データベース: PDB / ID: 3bow |
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タイトル | Structure of M-calpain in complex with Calpastatin |
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要素 | - Calpain small subunit 1
- Calpain-2 catalytic subunit
- Calpastatin
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キーワード | hydrolase/hydrolase inhibitor / cysteine protease / inhibitor / Cell membrane / Hydrolase / Membrane / Protease / Thiol protease / Phosphoprotein / Protease inhibitor / Thiol protease inhibitor / hydrolase-hydrolase inhibitor COMPLEX |
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機能・相同性 | 機能・相同性情報
egg activation / calcium-dependent cysteine-type endopeptidase inhibitor activity / calpain-2 / negative regulation of type B pancreatic cell apoptotic process / Degradation of the extracellular matrix / positive regulation of phosphatidylcholine biosynthetic process / calpain complex / calcium-dependent cysteine-type endopeptidase activity / perinuclear endoplasmic reticulum / myoblast fusion ...egg activation / calcium-dependent cysteine-type endopeptidase inhibitor activity / calpain-2 / negative regulation of type B pancreatic cell apoptotic process / Degradation of the extracellular matrix / positive regulation of phosphatidylcholine biosynthetic process / calpain complex / calcium-dependent cysteine-type endopeptidase activity / perinuclear endoplasmic reticulum / myoblast fusion / myoblast differentiation / regulation of interleukin-6 production / positive regulation of myoblast fusion / positive regulation of cardiac muscle cell apoptotic process / regulation of protein catabolic process / behavioral response to pain / pseudopodium / blastocyst development / protein autoprocessing / cellular response to interferon-beta / animal organ regeneration / response to mechanical stimulus / cytoskeletal protein binding / liver development / proteolysis involved in protein catabolic process / cell projection / female pregnancy / cellular response to amino acid stimulus / protein catabolic process / response to hydrogen peroxide / peptidase activity / cellular response to lipopolysaccharide / protease binding / postsynaptic density / lysosome / response to hypoxia / membrane raft / external side of plasma membrane / focal adhesion / neuronal cell body / calcium ion binding / dendrite / protein-containing complex binding / chromatin / Golgi apparatus / enzyme binding / endoplasmic reticulum / proteolysis / membrane / nucleus / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 Proteinase inhibitor I27, calpastatin / Calpastatin / Calpain inhibitor / CAPN2, penta-EF hand, calcium binding motif / Calpain subdomain III / Jelly Rolls - #380 / Peptidase C2, calpain, domain III / calpain_III / Peptidase C2, calpain, large subunit, domain III / Peptidase C2, calpain family ...Proteinase inhibitor I27, calpastatin / Calpastatin / Calpain inhibitor / CAPN2, penta-EF hand, calcium binding motif / Calpain subdomain III / Jelly Rolls - #380 / Peptidase C2, calpain, domain III / calpain_III / Peptidase C2, calpain, large subunit, domain III / Peptidase C2, calpain family / Calpain large subunit, domain III superfamily / Calpain large subunit, domain III / Peptidase C2, calpain, catalytic domain / Calpain family cysteine protease / Cysteine proteinase, calpain-type, catalytic domain profile. / Calpain-like thiol protease family. / EF-hand domain pair / Cysteine proteinases / Cysteine peptidase, cysteine active site / Eukaryotic thiol (cysteine) proteases cysteine active site. / Cathepsin B; Chain A / EF-hand / Recoverin; domain 1 / Papain-like cysteine peptidase superfamily / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair / Jelly Rolls / Alpha-Beta Complex / Sandwich / Orthogonal Bundle / Mainly Beta / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Calpastatin / Calpain-2 catalytic subunit / Calpain small subunit 1類似検索 - 構成要素 |
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生物種 | ![](img/tx_mammal.gif) Rattus norvegicus (ドブネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.4 Å |
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データ登録者 | Hanna, R.A. / Campbell, R.L. / Davies, P.L. |
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引用 | ジャーナル: Nature / 年: 2008 タイトル: Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin. 著者: Hanna, R.A. / Campbell, R.L. / Davies, P.L. |
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履歴 | 登録 | 2007年12月17日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2008年11月25日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Advisory / Version format compliance |
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改定 1.2 | 2021年10月20日 | Group: Database references / Derived calculations / カテゴリ: database_2 / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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改定 1.3 | 2023年8月30日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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