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Yorodumi- PDB-2x1w: Crystal Structure of VEGF-C in Complex with Domains 2 and 3 of VEGFR2 -
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-Basic information
Entry | Database: PDB / ID: 2x1w | |||||||||
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Title | Crystal Structure of VEGF-C in Complex with Domains 2 and 3 of VEGFR2 | |||||||||
Components | (VASCULAR ENDOTHELIAL GROWTH FACTOR ...) x 2 | |||||||||
Keywords | HORMONE/SIGNALING PROTEIN / HORMONE-SIGNALING PROTEIN COMPLEX / ANGIOGENESIS / GLYCOPROTEIN / HOST-VIRUS INTERACTION / MEMBRANE / RECEPTOR / LYMPHANGIOGENESIS / IMMUNOGLOBULIN DOMAIN / DEVELOPMENTAL PROTEIN / TRANSMEMBRANE / PHOSPHOPROTEIN / DISULFIDE BOND / MITOGEN | |||||||||
Function / homology | Function and homology information vascular endothelial growth factor receptor 3 binding / substrate-dependent cell migration / regulation of vascular endothelial growth factor receptor signaling pathway / positive regulation of lymphangiogenesis / blood vessel endothelial cell differentiation / cellular response to hydrogen sulfide / VEGF ligand-receptor interactions / positive regulation of mast cell chemotaxis / regulation of bone development / positive regulation of mesenchymal stem cell proliferation ...vascular endothelial growth factor receptor 3 binding / substrate-dependent cell migration / regulation of vascular endothelial growth factor receptor signaling pathway / positive regulation of lymphangiogenesis / blood vessel endothelial cell differentiation / cellular response to hydrogen sulfide / VEGF ligand-receptor interactions / positive regulation of mast cell chemotaxis / regulation of bone development / positive regulation of mesenchymal stem cell proliferation / Signaling by membrane-tethered fusions of PDGFRA or PDGFRB / morphogenesis of embryonic epithelium / vascular endothelial growth factor binding / Neurophilin interactions with VEGF and VEGFR / vascular endothelial growth factor receptor-2 signaling pathway / VEGF binds to VEGFR leading to receptor dimerization / endothelium development / endocardium development / vascular wound healing / regulation of hematopoietic progenitor cell differentiation / vascular endothelial growth factor receptor activity / post-embryonic camera-type eye morphogenesis / endothelial cell differentiation / positive regulation of vasculogenesis / mesenchymal cell proliferation / lymph vessel development / induction of positive chemotaxis / positive regulation of BMP signaling pathway / surfactant homeostasis / cell migration involved in sprouting angiogenesis / epithelial cell maturation / anchoring junction / sprouting angiogenesis / positive regulation of positive chemotaxis / embryonic hemopoiesis / vascular endothelial growth factor signaling pathway / positive regulation of mesenchymal cell proliferation / positive regulation of endothelial cell chemotaxis / positive regulation of cell migration involved in sprouting angiogenesis / branching involved in blood vessel morphogenesis / positive regulation of mitochondrial depolarization / positive regulation of mitochondrial fission / positive regulation of neuroblast proliferation / lung alveolus development / positive regulation of stem cell proliferation / chemoattractant activity / positive regulation of nitric-oxide synthase biosynthetic process / growth factor binding / sorting endosome / positive regulation of focal adhesion assembly / regulation of MAPK cascade / semaphorin-plexin signaling pathway / positive regulation of cell division / positive regulation of macroautophagy / positive regulation of blood vessel endothelial cell migration / cellular response to vascular endothelial growth factor stimulus / negative regulation of osteoblast differentiation / vasculogenesis / Integrin cell surface interactions / glial cell proliferation / cell fate commitment / vascular endothelial growth factor receptor signaling pathway / coreceptor activity / negative regulation of endothelial cell apoptotic process / calcium ion homeostasis / peptidyl-tyrosine autophosphorylation / ovarian follicle development / positive regulation of glial cell proliferation / positive regulation of protein autophosphorylation / cell surface receptor protein tyrosine kinase signaling pathway / positive regulation of endothelial cell proliferation / negative regulation of blood pressure / positive regulation of endothelial cell migration / transmembrane receptor protein tyrosine kinase activity / platelet alpha granule lumen / VEGFR2 mediated cell proliferation / stem cell proliferation / epithelial cell proliferation / cellular response to leukemia inhibitory factor / positive regulation of protein secretion / animal organ morphogenesis / growth factor activity / Hsp90 protein binding / receptor protein-tyrosine kinase / VEGFA-VEGFR2 Pathway / peptidyl-tyrosine phosphorylation / positive regulation of angiogenesis / integrin binding / cell migration / Platelet degranulation / cell junction / regulation of cell shape / protein tyrosine kinase activity / angiogenesis / negative regulation of neuron apoptotic process / positive regulation of MAPK cascade / protein autophosphorylation / positive regulation of ERK1 and ERK2 cascade / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / early endosome Similarity search - Function | |||||||||
Biological species | HOMO SAPIENS (human) | |||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / SIRAS / Resolution: 2.7 Å | |||||||||
Authors | Leppanen, V.M. / Prota, A.E. / Jeltsch, M. / Anisimov, A. / Kalkkinen, N. / Strandin, T. / Lankinen, H. / Goldman, A. / Ballmer-Hofer, K. / Alitalo, K. | |||||||||
Citation | Journal: Proc.Natl.Acad.Sci.USA / Year: 2010 Title: Structural Determinants of Growth Factor Binding and Specificity by Vegf Receptor 2. Authors: Leppanen, V.M. / Prota, A.E. / Jeltsch, M. / Anisimov, A. / Kalkkinen, N. / Strandin, T. / Lankinen, H. / Goldman, A. / Ballmer-Hofer, K. / Alitalo, K. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 2x1w.cif.gz | 482.1 KB | Display | PDBx/mmCIF format |
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PDB format | pdb2x1w.ent.gz | 405.6 KB | Display | PDB format |
PDBx/mmJSON format | 2x1w.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/x1/2x1w ftp://data.pdbj.org/pub/pdb/validation_reports/x1/2x1w | HTTPS FTP |
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-Related structure data
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Noncrystallographic symmetry (NCS) | NCS domain:
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