Entry Database : PDB / ID : 2x04 Structure visualization Downloads & linksTitle Crystal structure of the PABC-TNRC6C complex ComponentsPOLYADENYLATE-BINDING PROTEIN 1 TRINUCLEOTIDE REPEAT-CONTAINING GENE 6C PROTEIN DetailsKeywords PEPTIDE/RNA BINDING PROTEIN / PEPTIDE-RNA BINDING PROTEIN COMPLEX / RNA-MEDIATED GENE SILENCING / NUCLEUS / METHYLATION / SPLICEOSOME / TRANSLATION REGULATION / PROTEIN-PROTEIN COMPLEX / COILED COIL / DEADENYLATION / MRNA SPLICING / PHOSPHOPROTEIN / MRNA PROCESSING / MICRORNA SILENCINGFunction / homology Function and homology informationFunction Domain/homology Component
negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / mCRD-mediated mRNA stability complex / Regulation of CDH11 mRNA translation by microRNAs / Regulation of NPAS4 mRNA translation / Post-transcriptional silencing by small RNAs / Competing endogenous RNAs (ceRNAs) regulate PTEN translation / Regulation of PTEN mRNA translation / translation activator activity / negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / CRD-mediated mRNA stabilization ... negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / mCRD-mediated mRNA stability complex / Regulation of CDH11 mRNA translation by microRNAs / Regulation of NPAS4 mRNA translation / Post-transcriptional silencing by small RNAs / Competing endogenous RNAs (ceRNAs) regulate PTEN translation / Regulation of PTEN mRNA translation / translation activator activity / negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / CRD-mediated mRNA stabilization / Transcriptional Regulation by MECP2 / Z-decay: degradation of maternal mRNAs by zygotically expressed factors / miRNA-mediated post-transcriptional gene silencing / Deadenylation of mRNA / miRNA-mediated gene silencing by inhibition of translation / positive regulation of cytoplasmic translation / Regulation of MITF-M-dependent genes involved in apoptosis / M-decay: degradation of maternal mRNAs by maternally stored factors / poly(A) binding / regulatory ncRNA-mediated gene silencing / mRNA stabilization / poly(U) RNA binding / Regulation of RUNX1 Expression and Activity / positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / Translation initiation complex formation / cell leading edge / positive regulation of nuclear-transcribed mRNA poly(A) tail shortening / Regulation of MECP2 expression and activity / Transcriptional Regulation by VENTX / Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) / L13a-mediated translational silencing of Ceruloplasmin expression / positive regulation of viral genome replication / Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) / Nuclear events stimulated by ALK signaling in cancer / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / catalytic step 2 spliceosome / AUF1 (hnRNP D0) binds and destabilizes mRNA / mRNA 3'-UTR binding / TP53 Regulates Metabolic Genes / P-body / MAPK6/MAPK4 signaling / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / Oncogene Induced Senescence / Pre-NOTCH Transcription and Translation / Regulation of expression of SLITs and ROBOs / mRNA splicing, via spliceosome / cytoplasmic stress granule / cytoplasmic ribonucleoprotein granule / lamellipodium / Ca2+ pathway / Oxidative Stress Induced Senescence / Estrogen-dependent gene expression / ribonucleoprotein complex / focal adhesion / mRNA binding / RNA binding / extracellular exosome / nucleoplasm / membrane / nucleus / cytosol / cytoplasm Similarity search - Function TNRC6C, RNA recognition motif / Trinucleotide repeat-containing gene 6C protein, UBA domain / : / GW182, middle domain / M domain of GW182 / TNRC6, PABC binding domain / TNRC6-PABC binding domain / Argonaute hook domain / Argonaute hook / c-terminal domain of poly(a) binding protein ... TNRC6C, RNA recognition motif / Trinucleotide repeat-containing gene 6C protein, UBA domain / : / GW182, middle domain / M domain of GW182 / TNRC6, PABC binding domain / TNRC6-PABC binding domain / Argonaute hook domain / Argonaute hook / c-terminal domain of poly(a) binding protein / c-terminal domain of poly(a) binding protein / : / PABP, RNA recognition motif 2 / Polyadenylate binding protein, human types 1, 2, 3, 4 / Polyadenylate-binding protein/Hyperplastic disc protein / Poly-adenylate binding protein, unique domain / Poly(A)-binding protein C-terminal (PABC) domain profile. / C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. / PABC (PABP) domain / RNA recognition motif domain, eukaryote / RNA recognition motif / UBA/TS-N domain / Ubiquitin associated domain / Ubiquitin-associated domain / Ubiquitin-associated domain (UBA) profile. / UBA-like superfamily / RNA recognition motif / RNA recognition motif / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / RNA-binding domain superfamily / Nucleotide-binding alpha-beta plait domain superfamily / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / SAD / Resolution : 1.49 Å DetailsAuthors Jinek, M. / Fabian, M.R. / Coyle, S.M. / Sonenberg, N. / Doudna, J.A. CitationJournal : Nat.Struct.Mol.Biol. / Year : 2010Title : Structural Insights Into the Human Gw182-Pabc Interaction in Microrna-Mediated DeadenylationAuthors : Jinek, M. / Fabian, M.R. / Coyle, S.M. / Sonenberg, N. / Doudna, J.A. History Deposition Dec 4, 2009 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jan 19, 2010 Provider : repository / Type : Initial releaseRevision 1.1 May 8, 2011 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 May 8, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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