+Open data
-Basic information
Entry | Database: PDB / ID: 2w2w | ||||||
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Title | PLCg2 Split Pleckstrin Homology (PH) Domain | ||||||
Components | 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2 | ||||||
Keywords | HYDROLASE / PHOSPHOLIPASE C / PHOSPHOINOSITIDES / RHO GTPASES / RAC / SH2 DOMAIN / SH3 DOMAIN | ||||||
Function / homology | Function and homology information follicular B cell differentiation / inositol trisphosphate biosynthetic process / regulation of calcineurin-NFAT signaling cascade / positive regulation of dendritic cell cytokine production / phosphoinositide phospholipase C / antifungal innate immune response / positive regulation of interleukin-23 production / phospholipid catabolic process / cellular response to lectin / phosphorylation-dependent protein binding ...follicular B cell differentiation / inositol trisphosphate biosynthetic process / regulation of calcineurin-NFAT signaling cascade / positive regulation of dendritic cell cytokine production / phosphoinositide phospholipase C / antifungal innate immune response / positive regulation of interleukin-23 production / phospholipid catabolic process / cellular response to lectin / phosphorylation-dependent protein binding / positive regulation of cell cycle G1/S phase transition / positive regulation of I-kappaB phosphorylation / response to yeast / intracellular vesicle / phosphatidylinositol metabolic process / Toll Like Receptor 4 (TLR4) Cascade / cell activation / positive regulation of neuroinflammatory response / positive regulation of phagocytosis, engulfment / phosphatidylinositol phospholipase C activity / Erythropoietin activates Phospholipase C gamma (PLCG) / phospholipase C activity / programmed cell death / phosphatidylinositol biosynthetic process / macrophage activation involved in immune response / cellular response to lipid / negative regulation of programmed cell death / regulation of canonical NF-kappaB signal transduction / positive regulation of macrophage cytokine production / positive regulation of reactive oxygen species biosynthetic process / positive regulation of NLRP3 inflammasome complex assembly / toll-like receptor signaling pathway / positive regulation of epithelial cell migration / Dectin-2 family / Synthesis of IP3 and IP4 in the cytosol / stimulatory C-type lectin receptor signaling pathway / Fc-epsilon receptor signaling pathway / phosphatidylinositol-mediated signaling / positive regulation of receptor internalization / positive regulation of interleukin-10 production / regulation of lipid metabolic process / Generation of second messenger molecules / response to axon injury / positive regulation of type I interferon production / Role of phospholipids in phagocytosis / release of sequestered calcium ion into cytosol / lipopolysaccharide-mediated signaling pathway / GPVI-mediated activation cascade / cellular response to calcium ion / positive regulation of interleukin-12 production / positive regulation of calcium-mediated signaling / positive regulation of interleukin-2 production / phosphotyrosine residue binding / FCERI mediated Ca+2 mobilization / B cell differentiation / FCGR3A-mediated IL10 synthesis / protein tyrosine kinase binding / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / FCERI mediated MAPK activation / B cell receptor signaling pathway / ruffle membrane / calcium-mediated signaling / positive regulation of DNA-binding transcription factor activity / platelet activation / CLEC7A (Dectin-1) signaling / Wnt signaling pathway / positive regulation of interleukin-6 production / Signaling by CSF1 (M-CSF) in myeloid cells / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of tumor necrosis factor production / DAP12 signaling / positive regulation of NF-kappaB transcription factor activity / T cell receptor signaling pathway / scaffold protein binding / Potential therapeutics for SARS / positive regulation of MAPK cascade / intracellular signal transduction / membrane raft / positive regulation of gene expression / protein kinase binding / perinuclear region of cytoplasm / extracellular exosome / plasma membrane / cytoplasm / cytosol Similarity search - Function | ||||||
Biological species | HOMO SAPIENS (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.8 Å | ||||||
Authors | Opaleye, O. / Bunney, T.D. / Roe, S.M. / Pearl, L.H. | ||||||
Citation | Journal: Mol.Cell / Year: 2009 Title: Structural Insights Into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2. Authors: Bunney, T.D. / Opaleye, O. / Roe, S.M. / Vatter, P. / Baxendale, R.W. / Walliser, C. / Everett, K.L. / Josephs, M.B. / Christow, C. / Rodrigues-Lima, F. / Gierschik, P. / Pearl, L.H. / Katan, M. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 2w2w.cif.gz | 242 KB | Display | PDBx/mmCIF format |
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PDB format | pdb2w2w.ent.gz | 193.2 KB | Display | PDB format |
PDBx/mmJSON format | 2w2w.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 2w2w_validation.pdf.gz | 537.1 KB | Display | wwPDB validaton report |
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Full document | 2w2w_full_validation.pdf.gz | 601.6 KB | Display | |
Data in XML | 2w2w_validation.xml.gz | 44.3 KB | Display | |
Data in CIF | 2w2w_validation.cif.gz | 61 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/w2/2w2w ftp://data.pdbj.org/pub/pdb/validation_reports/w2/2w2w | HTTPS FTP |
-Related structure data
Related structure data | 2w2tC 2w2vC 2w2xC 1upqS C: citing same article (ref.) S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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