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Structure paper

TitleStructural Insights Into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2.
Journal, issue, pagesMol. Cell, Vol. 34, Page 223-, Year 2009
Publish dateNov 4, 2008 (structure data deposition date)
AuthorsBunney, T.D. / Opaleye, O. / Roe, S.M. / Vatter, P. / Baxendale, R.W. / Walliser, C. / Everett, K.L. / Josephs, M.B. / Christow, C. / Rodrigues-Lima, F. ...Bunney, T.D. / Opaleye, O. / Roe, S.M. / Vatter, P. / Baxendale, R.W. / Walliser, C. / Everett, K.L. / Josephs, M.B. / Christow, C. / Rodrigues-Lima, F. / Gierschik, P. / Pearl, L.H. / Katan, M.
External linksMol. Cell / PubMed:19394299
MethodsX-ray diffraction
Resolution1.95 - 2.8 Å
Structure data

PDB-2w2t:
Rac2 (G12V) in complex with GDP
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-2w2v:
Rac2 (G12V) in complex with GTPgS
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-2w2w:
PLCg2 Split Pleckstrin Homology (PH) Domain
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-2w2x:
Complex of Rac2 and PLCg2 spPH Domain
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-HOH:
WATER

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-GSP:
5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / PHOSPHOLIPASE C / PHOSPHOINOSITIDES / RHO GTPASES / RAC SIGNALING PROTEIN / ADP-RIBOSYLATION / CYTOPLASM / DISEASE MUTATION / GTP-BINDING / LIPOPROTEIN / METHYLATION / NUCLEOTIDE-BINDING / POLYMORPHISM / PRENYLATION / RHO / HYDROLASE / RAC / SH2 DOMAIN / SH3 DOMAIN / SIGNALING PROTEIN/HYDROLASE / SIGNALING PROTEIN-HYDROLASE complex

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