Entry | Database: PDB / ID: 2v8c |
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Title | Mouse Profilin IIa in complex with the proline-rich domain of VASP |
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Components | - PROFILIN-2
- VASODILATOR-STIMULATED PHOSPHOPROTEIN
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Keywords | PROTEIN BINDING / ALTERNATIVE SPLICING / PROTEIN-BINDING / CYTOPLASM / ACETYLATION / CYTOSKELETON / ACTIN-BINDING |
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Function / homology | Function and homology information
Signaling by ROBO receptors / Cell-extracellular matrix interactions / negative regulation of ruffle assembly / modification of postsynaptic actin cytoskeleton / negative regulation of epithelial cell migration / RHO GTPases Activate Formins / profilin binding / positive regulation of actin filament bundle assembly / negative regulation of actin filament polymerization / regulation of actin filament polymerization ...Signaling by ROBO receptors / Cell-extracellular matrix interactions / negative regulation of ruffle assembly / modification of postsynaptic actin cytoskeleton / negative regulation of epithelial cell migration / RHO GTPases Activate Formins / profilin binding / positive regulation of actin filament bundle assembly / negative regulation of actin filament polymerization / regulation of actin filament polymerization / actin polymerization or depolymerization / filopodium membrane / regulation of synaptic vesicle exocytosis / positive regulation of actin filament polymerization / lamellipodium membrane / actin monomer binding / bicellular tight junction / positive regulation of stress fiber assembly / phosphatidylinositol-4,5-bisphosphate binding / presynaptic modulation of chemical synaptic transmission / filopodium / neural tube closure / axon guidance / Schaffer collateral - CA1 synapse / modulation of chemical synaptic transmission / SH3 domain binding / presynapse / positive regulation of peptidyl-serine phosphorylation / lamellipodium / actin binding / actin cytoskeleton organization / postsynapse / protein homotetramerization / cytoskeleton / protein stabilization / focal adhesion / glutamatergic synapse / ATP hydrolysis activity / plasma membrane / cytoplasm / cytosolSimilarity search - Function Vasodilator-stimulated phosphoprotein / : / Vasodilator-stimulated phosphoprotein/ENA/VASP-like / Profilin1/2/3, vertebrate / VASP tetramerisation / VASP tetramerisation domain superfamily / VASP tetramerisation domain / : / Profilin conserved site / Profilin signature. ...Vasodilator-stimulated phosphoprotein / : / Vasodilator-stimulated phosphoprotein/ENA/VASP-like / Profilin1/2/3, vertebrate / VASP tetramerisation / VASP tetramerisation domain superfamily / VASP tetramerisation domain / : / Profilin conserved site / Profilin signature. / WH1/EVH1 domain / WH1 domain / WH1 domain profile. / WASP homology region 1 / Profilin / Profilin / Profilin / Profilin superfamily / Dynein light chain 2a, cytoplasmic / Beta-Lactamase / PH-like domain superfamily / 2-Layer Sandwich / Alpha BetaSimilarity search - Domain/homology |
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Biological species | ![](img/tx_mammal.gif) MUS MUSCULUS (house mouse) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.98 Å |
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Authors | Kursula, P. / Downer, J. / Witke, W. / Wilmanns, M. |
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Citation | Journal: J.Mol.Biol. / Year: 2008 Title: High-Resolution Structural Analysis of Mammalian Profilin 2A Complex Formation with Two Physiological Ligands: The Formin Homology 1 Domain of Mdia1 and the Proline-Rich Domain of Vasp. Authors: Kursula, P. / Kursula, I. / Massimi, M. / Song, Y.H. / Downer, J. / Stanley, W.A. / Witke, W. / Wilmanns, M. |
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History | Deposition | Aug 6, 2007 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Dec 18, 2007 | Provider: repository / Type: Initial release |
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Revision 1.1 | Dec 21, 2016 | Group: Database references / Derived calculations ...Database references / Derived calculations / Non-polymer description / Other / Source and taxonomy / Structure summary / Version format compliance |
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Revision 1.2 | Dec 13, 2023 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Other / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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