Entry Database : PDB / ID : 2v4z Structure visualization Downloads & linksTitle The crystal structure of the human G-protein subunit alpha (GNAI3) in complex with an engineered regulator of G-protein signaling type 2 domain (RGS2) ComponentsGUANINE NUCLEOTIDE-BINDING PROTEIN G(K) SUBUNIT ALPHA REGULATOR OF G-PROTEIN SIGNALING 2 DetailsKeywords CELL CYCLE / GTP HYDROLYSIS / ADP-RIBOSYLATION / NUCLEOTIDE-BINDING / LIPOPROTEIN / GTP-BINDING / PHOSPHOPROTEIN / SIGNAL TRANSDUCTION INHIBITOR / GUANINE NUCLEOTIDE BINDING PROTEIN / TRANSMEMBRANE SIGNALING / G-PROTEIN COUPLED RECEPTOR / PALMITATE / MYRISTATE / TRANSDUCERFunction / homology Function and homology informationFunction Domain/homology Component
negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process / negative regulation of phospholipase activity / negative regulation of glycine import across plasma membrane / adenylate cyclase inhibitor activity / zymogen granule / ovulation / negative regulation of cardiac muscle hypertrophy / negative regulation of G protein-coupled receptor signaling pathway / negative regulation of cell growth involved in cardiac muscle cell development / positive regulation of NAD(P)H oxidase activity ... negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process / negative regulation of phospholipase activity / negative regulation of glycine import across plasma membrane / adenylate cyclase inhibitor activity / zymogen granule / ovulation / negative regulation of cardiac muscle hypertrophy / negative regulation of G protein-coupled receptor signaling pathway / negative regulation of cell growth involved in cardiac muscle cell development / positive regulation of NAD(P)H oxidase activity / regulation of G protein-coupled receptor signaling pathway / vesicle fusion / negative regulation of adenylate cyclase activity / relaxation of vascular associated smooth muscle / dopamine receptor signaling pathway / GTP metabolic process / beta-tubulin binding / relaxation of cardiac muscle / GTPase activating protein binding / brown fat cell differentiation / Adenylate cyclase inhibitory pathway / positive regulation of cardiac muscle contraction / G protein-coupled serotonin receptor binding / positive regulation of macroautophagy / G-protein alpha-subunit binding / maternal process involved in female pregnancy / negative regulation of apoptotic signaling pathway / positive regulation of vascular associated smooth muscle cell proliferation / cytoplasmic side of plasma membrane / ADP signalling through P2Y purinoceptor 12 / G-protein beta/gamma-subunit complex binding / adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway / response to amphetamine / positive regulation of superoxide anion generation / G alpha (z) signalling events / GTPase activator activity / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / positive regulation of neuron projection development / GPER1 signaling / heterotrimeric G-protein complex / negative regulation of MAP kinase activity / ADORA2B mediated anti-inflammatory cytokines production / G protein-coupled receptor binding / GDP binding / G alpha (i) signalling events / G alpha (s) signalling events / G alpha (q) signalling events / midbody / brain development / spermatogenesis / Extra-nuclear estrogen signaling / negative regulation of translation / response to ethanol / calmodulin binding / lysosomal membrane / G protein-coupled receptor signaling pathway / cell cycle / cell division / neuron projection / centrosome / GTPase activity / membrane raft / protein domain specific binding / GTP binding / nucleolus / Golgi apparatus / mitochondrion / extracellular exosome / membrane / metal ion binding / nucleus / plasma membrane / cytosol / cytoplasm Similarity search - Function Regulator of G-protein signalling 2 / Regulator of G-protein Signalling 4; domain 1 - #10 / Regulator of G-protein Signalling 4; domain 1 / RGS, subdomain 1/3 / Regulator of G-protein Signalling 4, domain 2 / Regulator of G-protein Signalling 4; domain 2 / GI Alpha 1, domain 2-like / GI Alpha 1, domain 2-like / Regulator of G protein signaling domain / RGS, subdomain 2 ... Regulator of G-protein signalling 2 / Regulator of G-protein Signalling 4; domain 1 - #10 / Regulator of G-protein Signalling 4; domain 1 / RGS, subdomain 1/3 / Regulator of G-protein Signalling 4, domain 2 / Regulator of G-protein Signalling 4; domain 2 / GI Alpha 1, domain 2-like / GI Alpha 1, domain 2-like / Regulator of G protein signaling domain / RGS, subdomain 2 / RGS domain / RGS domain profile. / Regulator of G protein signalling domain / RGS domain superfamily / G-protein alpha subunit, group I / G-alpha domain profile. / Guanine nucleotide binding protein (G-protein), alpha subunit / G protein alpha subunit, helical insertion / G-protein alpha subunit / G protein alpha subunit / P-loop containing nucleotide triphosphate hydrolases / P-loop containing nucleoside triphosphate hydrolase / Rossmann fold / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta Similarity search - Domain/homology TETRAFLUOROALUMINATE ION / GUANOSINE-5'-DIPHOSPHATE / Guanine nucleotide-binding protein G(i) subunit alpha-3 / Regulator of G-protein signaling 2 Similarity search - ComponentBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution : 2.8 Å DetailsAuthors Roos, A.K. / Soundararajan, M. / Pike, A.C.W. / Arrowsmith, C.H. / Weigelt, J. / Edwards, A. / Bountra, C. / Knapp, S. CitationJournal : J.Biol.Chem. / Year : 2009Title : Structural Determinants of G-Protein Alpha Subunit Selectivity by Regulator of G-Protein Signaling 2(Rgs2).Authors : Kimple, A.J. / Soundararajan, M. / Hutsell, S.Q. / Roos, A.K. / Urban, D.J. / Setola, V. / Temple, B.R. / Roth, B.L. / Knapp, S. / Willard, F.S. / Siderovski, D.P. History Deposition Sep 30, 2008 Deposition site : PDBE / Processing site : PDBERevision 1.0 Nov 4, 2008 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Advisory / Version format complianceRevision 1.2 Apr 4, 2018 Group : Data collection / Category : diffrn_source / Item : _diffrn_source.type
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