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Structure paper

TitleStructural Determinants of G-Protein Alpha Subunit Selectivity by Regulator of G-Protein Signaling 2(Rgs2).
Journal, issue, pagesJ. Biol. Chem., Vol. 284, Page 19402-, Year 2009
Publish dateSep 30, 2008 (structure data deposition date)
AuthorsKimple, A.J. / Soundararajan, M. / Hutsell, S.Q. / Roos, A.K. / Urban, D.J. / Setola, V. / Temple, B.R. / Roth, B.L. / Knapp, S. / Willard, F.S. / Siderovski, D.P.
External linksJ. Biol. Chem. / PubMed:19478087
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-2v4z:
The crystal structure of the human G-protein subunit alpha (GNAI3) in complex with an engineered regulator of G-protein signaling type 2 domain (RGS2)
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM / Guanosine diphosphate

ChemComp-ALF:
TETRAFLUOROALUMINATE ION

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER / Water

Source
  • homo sapiens (human)
KeywordsCELL CYCLE / GTP HYDROLYSIS / ADP-RIBOSYLATION / NUCLEOTIDE-BINDING / LIPOPROTEIN / GTP-BINDING / PHOSPHOPROTEIN / SIGNAL TRANSDUCTION INHIBITOR / GUANINE NUCLEOTIDE BINDING PROTEIN / TRANSMEMBRANE SIGNALING / G-PROTEIN COUPLED RECEPTOR / PALMITATE / MYRISTATE / TRANSDUCER

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