+Open data
-Basic information
Entry | Database: PDB / ID: 2qtj | ||||||
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Title | Solution structure of human dimeric immunoglobulin A | ||||||
Components |
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Keywords | IMMUNE SYSTEM / X-ray and neutron solution scattering / immunology / antibody / immunoglobulin A1 / Chromophore / Glycoprotein / Immunoglobulin C region / Immunoglobulin domain | ||||||
Function / homology | Function and homology information secretory dimeric IgA immunoglobulin complex / monomeric IgA immunoglobulin complex / secretory IgA immunoglobulin complex / glomerular filtration / IgA immunoglobulin complex / IgG immunoglobulin complex / positive regulation of respiratory burst / Scavenging of heme from plasma / immunoglobulin complex, circulating / complement activation, classical pathway ...secretory dimeric IgA immunoglobulin complex / monomeric IgA immunoglobulin complex / secretory IgA immunoglobulin complex / glomerular filtration / IgA immunoglobulin complex / IgG immunoglobulin complex / positive regulation of respiratory burst / Scavenging of heme from plasma / immunoglobulin complex, circulating / complement activation, classical pathway / antigen binding / Cell surface interactions at the vascular wall / B cell receptor signaling pathway / antibacterial humoral response / adaptive immune response / blood microparticle / immune response / extracellular space / extracellular exosome / extracellular region / membrane / plasma membrane Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | SOLUTION SCATTERING | ||||||
Authors | Bonner, A. / Furtado, P.B. / Almogren, A. / Kerr, M.A. / Perkins, S.J. | ||||||
Citation | Journal: J.Immunol. / Year: 2008 Title: Implications of the near-planar solution structure of human myeloma dimeric IgA1 for mucosal immunity and IgA nephropathy Authors: Bonner, A. / Furtado, P.B. / Almogren, A. / Kerr, M.A. / Perkins, S.J. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 2qtj.cif.gz | 630.1 KB | Display | PDBx/mmCIF format |
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PDB format | pdb2qtj.ent.gz | 517.1 KB | Display | PDB format |
PDBx/mmJSON format | 2qtj.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 2qtj_validation.pdf.gz | 316 KB | Display | wwPDB validaton report |
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Full document | 2qtj_full_validation.pdf.gz | 317.8 KB | Display | |
Data in XML | 2qtj_validation.xml.gz | 1.2 KB | Display | |
Data in CIF | 2qtj_validation.cif.gz | 243.5 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/qt/2qtj ftp://data.pdbj.org/pub/pdb/validation_reports/qt/2qtj | HTTPS FTP |
-Related structure data
Related structure data | |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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1 |
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2 |
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Number of models | 10 |
Details | Two light chains (L and M or N and O) bind to two heavy chains (A and B or C and D) within each IgA monomer. Two IgA monomers then form the dimeric IgA molecule. |
-Components
#1: Antibody | Mass: 23216.770 Da / Num. of mol.: 4 / Source method: isolated from a natural source Details: Dimeric IgA1 was purified by thiophilic and jacalin affinity chromatography. Source: (natural) Homo sapiens (human) #2: Antibody | Mass: 51068.383 Da / Num. of mol.: 4 / Source method: isolated from a natural source Details: Kappa light chain dimeric IgA1 was isolated from myeloma serum. Source: (natural) Homo sapiens (human) / References: UniProt: P01876, UniProt: Q6MZW0*PLUS |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION SCATTERING |
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-Data collection
Detector | Date: Jul 1, 2001 | ||||||||||||||||||||||||||||||||||||||||||
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Radiation | Monochromator: MIRROR / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray | ||||||||||||||||||||||||||||||||||||||||||
Radiation wavelength | Relative weight: 1 | ||||||||||||||||||||||||||||||||||||||||||
Soln scatter | Buffer name: 140 MM NACL 12.5 MM NAHPO4 0.5 MM EDTA 0.02% NA AZIDE / Data analysis software list: SCTPL7, GNOM / Protein length: 1 / Sample pH: 7.5 / Source class: Y / Temperature: 288 K
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-Processing
Software |
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Refinement step | Cycle: LAST
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Soln scatter model | Num. of conformers submitted: 10 / Representative conformer: 1 / Software list: INSIGHT II, SCTPL7, GNOM |