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- PDB-2qfw: Crystal structure of Saccharomyces cerevesiae mitochondrial NADP(... -

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Open data

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Basic information

Entry

Database: PDB / ID: 2qfw

Title

Crystal structure of Saccharomyces cerevesiae mitochondrial NADP(+)-dependent isocitrate dehydrogenase in complex with isocitrate

Components

Isocitrate dehydrogenase [NADP]

Keywords

OXIDOREDUCTASE /

Rossmann fold

Function / homology

Function and homology information

NADPH regeneration /

Peroxisomal protein import / glutamate biosynthetic process / isocitrate metabolic process /

isocitrate dehydrogenase (NADP+) /

isocitrate dehydrogenase (NADP+) activity / NADP metabolic process /

glyoxylate cycle / mitochondrial nucleoid /

tricarboxylic acid cycle ...
Similarity search - Function

Biological species

Saccharomyces cerevisiae (brewer's yeast)

Method

X-RAY DIFFRACTION /

MOLECULAR REPLACEMENT / Resolution: 2.6 Å

Authors

Peng, Y.J. / Ding, J.P.

Citation

Journal: Protein Sci. / Year: 2008
Title: Structural studies of Saccharomyces cerevesiae mitochondrial NADP-dependent isocitrate dehydrogenase in different enzymatic states reveal substantial conformational changes during the catalytic reaction
Authors: Peng, Y.J. / Zhong, C. / Huang, W. / Ding, J.P.

History

Deposition	Jun 28, 2007	Deposition site: RCSB / Processing site: PDBJ
Revision 1.0	Jul 1, 2008	Provider: repository / Type: Initial release
Revision 1.1	Jul 13, 2011	Group: Advisory / Version format compliance
Revision 1.2	Oct 25, 2023	Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id

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Structure visualization

Structure viewer	Molecule: MolmilJmol/JSmol

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Downloads & links

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Download

PDBx/mmCIF format	2qfw.cif.gz	516.2 KB	Display	PDBx/mmCIF format
PDB format	pdb2qfw.ent.gz	429.8 KB	Display	PDB format
PDBx/mmJSON format	2qfw.json.gz		Tree view	PDBx/mmJSON format
Others	Other downloads

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Validation report

Arichive directory	https://data.pdbj.org/pub/pdb/validation_reports/qf/2qfw ftp://data.pdbj.org/pub/pdb/validation_reports/qf/2qfw	HTTPS FTP

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Related structure data

Related structure data	2qfvC 2qfxC 2qfyC 1lwdS C: citing same article (ref.) S: Starting model for refinement
Similar structure data	2qfy-1 2qfy-3 3us8-d 2uxq-2 2qfy-2 6pay-2 2qfv-1 6o2y-2 5lge-2 6bky-3 Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Similarity search - Function & homologyF&H Search Similarity search - FunctionF&H Search Similarity search - HomologyF&H Search

Related structure data

C: citing same article (ref.)

S: Starting model for refinement

Similar structure data

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Links

PDB pages	PDBj / wwPDB / NCBI
Related items in Molecule of the Month	#129 - Sep 2010 Isocitrate Dehydrogenase similarity (7) #154 - Oct 2012 Citric Acid Cycle similarity (6) #89 - May 2007 Aconitase and Iron Regulatory Protein 1 similarity (1) #161 - May 2013 Ricin similarity (1) #50 - Feb 2004 Glycolytic Enzymes similarity (1) #166 - Oct 2013 Proteasome similarity (1) #196 - Apr 2016 Lead Poisoning similarity (1) #219 - Mar 2018 Vacuolar ATPase similarity (1) #108 - Dec 2008 Hsp90 similarity (1) #203 - Nov 2016 Aminopeptidase 1 and Autophagy similarity (1) #81 - Sep 2006 Elongation Factors similarity (1) #85 - Jan 2007 Importins similarity (1) #24 - Dec 2001 Glycogen Phosphorylase similarity (1) #60 - Dec 2004 Ubiquitin similarity (1)

PDB pages

PDBj /

wwPDB /

NCBI

Related items in Molecule of the Month

#129 - Sep 2010
Isocitrate Dehydrogenase
similarity (7)
#154 - Oct 2012
Citric Acid Cycle
similarity (6)
#89 - May 2007
Aconitase and Iron Regulatory Protein 1
similarity (1)
#161 - May 2013
Ricin
similarity (1)
#50 - Feb 2004
Glycolytic Enzymes
similarity (1)
#166 - Oct 2013
Proteasome
similarity (1)
#196 - Apr 2016
Lead Poisoning
similarity (1)
#219 - Mar 2018
Vacuolar ATPase
similarity (1)
#108 - Dec 2008
Hsp90
similarity (1)
#203 - Nov 2016
Aminopeptidase 1 and Autophagy
similarity (1)
#81 - Sep 2006
Elongation Factors
similarity (1)
#85 - Jan 2007
Importins
similarity (1)
#24 - Dec 2001
Glycogen Phosphorylase
similarity (1)
#60 - Dec 2004
Ubiquitin
similarity (1)

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Assembly

Deposited unit

A: Isocitrate dehydrogenase [NADP]

B: Isocitrate dehydrogenase [NADP]

C: Isocitrate dehydrogenase [NADP]

D: Isocitrate dehydrogenase [NADP]

E: Isocitrate dehydrogenase [NADP]

F: Isocitrate dehydrogenase [NADP]

hetero molecules

290 kDa, 6 polymers
Search similar-shape structures of this assembly by Omokage search (details)

A: Isocitrate dehydrogenase [NADP]

B: Isocitrate dehydrogenase [NADP]

hetero molecules

defined by author&software
96.7 kDa, 2 polymers
Search similar-shape structures of this assembly by Omokage search (details)

C: Isocitrate dehydrogenase [NADP]

D: Isocitrate dehydrogenase [NADP]

hetero molecules

defined by author&software
96.7 kDa, 2 polymers
Search similar-shape structures of this assembly by Omokage search (details)

E: Isocitrate dehydrogenase [NADP]

F: Isocitrate dehydrogenase [NADP]

hetero molecules

defined by author&software
96.7 kDa, 2 polymers
Search similar-shape structures of this assembly by Omokage search (details)

Unit cell

Length a, b, c (Å)	74.699, 97.886, 190.651
Angle α, β, γ (deg.)	90.000, 98.950, 90.000
Int Tables number	4
Space group name H-M	P12₁1

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Components

#1: Protein	Isocitrate dehydrogenase [NADP] / Idp1p / Oxalosuccinate decarboxylase / IDH / NADP+ / -specific ICDH / IDP Mass: 48143.086 Da / Num. of mol.: 6 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Saccharomyces cerevisiae (brewer's yeast) Strain: YPH499 / Gene: IDP1 / Plasmid: pET-3E-His / Production host: Escherichia coli (E. coli) / Strain (production host): BL21 (DE3) pLysS References: UniProt: P21954, isocitrate dehydrogenase (NADP+)
#2: Chemical	ChemComp-ICT / ISOCITRIC ACID / Isocitric acid Mass: 192.124 Da / Num. of mol.: 6 / Source method: obtained synthetically / Formula: C₆H₈O₇
#3: Water	ChemComp-HOH / water / Water Mass: 18.015 Da / Num. of mol.: 1158 / Source method: isolated from a natural source / Formula: H₂O

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Experimental details

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Experiment

Experiment	Method: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

Crystal	Density Matthews: 2.38 Å³/Da / Density % sol: 48.38 %
Crystal grow	Temperature: 293 K / Method: vapor diffusion, hanging drop / pH: 7.2 Details: 0.1M HEPES-Na, 0.2M Li2SO4, 0.1M NaF, 20% PEG 4000, pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 293.0K

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Data collection

Diffraction	Mean temperature: 95 K
Diffraction source	Source: ROTATING ANODE / Type: RIGAKU RUH3R / Wavelength: 1.5418 Å
Detector	Type: RIGAKU RAXIS IV++ / Detector: IMAGE PLATE / Date: Aug 22, 2005 / Details: MSC confocal max-flux optics
Radiation	Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelength	Wavelength: 1.5418 Å / Relative weight: 1
Reflection	Resolution: 2.6→19.9 Å / Num. obs: 82166 / % possible obs: 98.4 % / Redundancy: 2.62 % / B_iso Wilson estimate: 64.9 Å² / R_merge(I) obs: 0.06 / R_sym value: 0.06 / Χ²: 1.06 / Net I/σ(I): 9 / Scaling rejects: 11366
Reflection shell	Resolution: 2.6→2.69 Å / Redundancy: 2.66 % / R_merge(I) obs: 0.228 / Mean I/σ(I) obs: 2 / Num. measured all: 22349 / Num. unique all: 8296 / R_sym value: 0.06 / Χ²: 0.59 / % possible all: 99.9

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Phasing

Phasing MR

Cor.coef. F_o:F_c: 0.641 / Packing: 0.595

	Highest resolution	Lowest resolution	Method	Reflection percent	σ(F)
Translation	4 Å	10 Å	general	96.5	2

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Processing

Software

Name	Version	Classification
d*TREK	7.1SSI	data scaling
CNS		refinement
REFMAC		refinement
PDB_EXTRACT	2	data extraction
CrystalClear		data collection
CrystalClear		data reduction
CNS		phasing

Refinement

Method to determine structure:

MOLECULAR REPLACEMENT
Starting model: 1LWD

1lwd

Resolution: 2.6→20 Å / Cor.coef. F_o:F_c: 0.931 / Cor.coef. F_o:F_c free: 0.887 / SU B: 14.637 / SU ML: 0.299 / TLS residual ADP flag: LIKELY RESIDUAL / Cross valid method: THROUGHOUT / σ(F): 0 / ESU R Free: 0.401 / Stereochemistry target values: MAXIMUM LIKELIHOOD

	R_factor	Num. reflection	% reflection	Selection details
R_free	0.292	4154	5.1 %	RANDOM
R_work	0.232	-	-	-
obs	0.235	82147	98.38 %	-

Solvent computation

Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.4 Å / Solvent model: BABINET MODEL WITH MASK

Displacement parameters

B_iso mean: 51.646 Å²

	B_aniso -1	B_aniso -2	B_aniso -3
1-	1.39 Å²	0 Å²	-2.13 Å²
2-	-	-0.79 Å²	0 Å²
3-	-	-	-1.25 Å²

Refine analyze

	Free	Obs
Luzzati coordinate error	0.52 Å	0.42 Å
Luzzati d res low	-	5 Å
Luzzati sigma a	0.57 Å	0.44 Å

Refinement step

Cycle: LAST / Resolution: 2.6→20 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	19452	0	78	1158	20688

Refine LS restraints

Refine-ID	Type	Dev ideal	Dev ideal target	Number
X-RAY DIFFRACTION	r_bond_refined_d	0.005	0.022	19904
X-RAY DIFFRACTION	r_angle_refined_deg	0.89	1.969	26847
X-RAY DIFFRACTION	r_dihedral_angle_1_deg	3.941	5	2451
X-RAY DIFFRACTION	r_chiral_restr	0.059	0.2	2994
X-RAY DIFFRACTION	r_gen_planes_refined	0.002	0.02	14708
X-RAY DIFFRACTION	r_nbd_refined	0.187	0.2	10316
X-RAY DIFFRACTION	r_xyhbond_nbd_refined	0.107	0.2	1455
X-RAY DIFFRACTION	r_symmetry_vdw_refined	0.159	0.2	83
X-RAY DIFFRACTION	r_symmetry_hbond_refined	0.099	0.2	21
X-RAY DIFFRACTION	r_mcbond_it	0.693	1.5	12213
X-RAY DIFFRACTION	r_mcangle_it	1.319	2	19760
X-RAY DIFFRACTION	r_scbond_it	1.192	3	7691
X-RAY DIFFRACTION	r_scangle_it	2.166	4.5	7087

LS refinement shell

Resolution: 2.6→2.666 Å / Total num. of bins used: 20

	R_factor	Num. reflection
R_free	0.403	307
R_work	0.349	5778
obs	-	6085

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°²)	L12 (°²)	L13 (°²)	L22 (°²)	L23 (°²)	L33 (°²)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å²)	T12 (Å²)	T13 (Å²)	T22 (Å²)	T23 (Å²)	T33 (Å²)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	3.5683	0.227	-0.2744	0.8967	-0.2928	1.5912	0.0525	-0.2948	0.2042	0.0537	0.0771	-0.0838	0.0764	0.0832	-0.1296	0.1197	0.0011	-0.0351	0.0838	0.0002	0.0883	60.0167	-49.1411	70.8646
2	1.1444	1.5135	0.1619	2.9826	-0.4198	0.8605	0.0517	0.0399	0.0952	0.1364	-0.0147	-0.0451	-0.1422	-0.1777	-0.037	0.1147	0.0042	-0.0251	0.0817	0.0174	0.0958	59.9395	-40.5051	70.9534
3	6.2871	0.6554	0.5307	0.4605	-0.8358	0.4523	0.0908	-0.0199	-0.2344	0.0857	0.0755	-0.0505	0.1208	-0.1103	-0.1663	0.1295	-0.0245	-0.0434	0.1014	0.0024	0.0733	55.7238	-47.6535	74.7499
4	1.8954	0.8228	-1.1279	1.6193	-1.1942	3.2873	-0.0471	-0.0939	0.0917	0.1911	0.1149	0.0622	0.1112	-0.2536	-0.0678	0.1209	-0.0035	0.0054	0.0745	0.0096	0.083	59.862	-43.4599	85.1407
5	2.2379	-1.2213	0.1284	1.2246	0.2664	3.374	0.1083	0.0179	-0.1623	0.1064	-0.092	-0.2168	0.0795	-0.4752	-0.0163	0.0745	0.0104	0.0261	0.0564	-0.0276	0.0694	73.527	-57.8453	82.3822
6	1.1171	-1.1688	-0.9064	3.1488	1.3838	0.2342	0.2062	0.0732	0.0016	0.1677	-0.1407	0.2741	0.0475	0.111	-0.0655	0.1088	-0.0037	0.0323	0.1172	-0.0152	0.0639	70.9395	-48.0335	91.7319
7	1.2324	0.19	-0.3048	0.0001	0.2456	1.3132	0.0052	0.2146	0.2047	-0.0116	0.0947	0.0991	-0.0489	0.1854	-0.0998	0.1159	0.0196	-0.026	0.1091	0.0199	0.1077	83.1706	-23.859	87.7036
8	7.4425	-3.8714	-1.7005	-0.8219	-5.5938	-1.0259	0.3084	0.8591	0.2235	0.0924	-0.8009	0.2817	0.4642	-0.0577	0.4926	0.111	0.0258	-0.0199	0.108	0.0314	0.1339	84.5911	-26.1368	89.9469
9	-4.1227	0.8824	-0.8384	5.9337	-0.7317	-0.447	0.2569	0.1394	-0.5186	0.3115	-0.1516	-0.3296	0.0655	-0.22	-0.1054	0.1093	0.0314	-0.0191	0.0939	0.0089	0.0933	66.7907	-33.0219	98.1351
10	1.3341	-0.206	1.9389	4.425	2.6647	4.9245	0.0129	0.0787	0.081	0.1808	0.2147	0.0753	0.1267	0.1563	-0.2276	0.0997	-0.0108	-0.0033	0.0733	-0.003	0.0604	64.9303	-53.7026	98.7947
11	6.4426	5.1062	1.2725	4.5803	0.7175	-2.4278	0.3195	-0.1561	-0.1561	0.298	-0.1411	-0.3605	0.0947	-0.3303	-0.1784	0.1372	0.0435	-0.0035	0.0802	-0.0374	0.08	72.2537	-42.0665	104.4629
12	1.265	2.3142	-0.5987	0.7766	-0.9231	2.7914	0.3275	-0.3014	-0.4486	0.187	-0.2983	0.3822	-0.0394	0.2016	-0.0293	0.0848	-0.001	-0.0168	0.0739	-0.0058	0.0754	63.3523	-58.0265	100.5845
13	24.5534	17.6346	-3.7632	13.1874	0.0368	2.5504	0.2557	0.1567	1.0262	0.3445	0.2077	0.9516	-0.2402	0.5616	-0.4634	0.0909	0.022	-0.0063	0.1589	-0.0144	0.0608	75.9379	-44.127	103.9288
14	3.1945	-2.8454	3.4471	4.388	1.3907	1.8566	-0.0739	0.2421	0.3179	-0.0071	-0.4448	-0.2584	-0.1721	0.5745	0.5187	0.0615	0.0065	0.0065	0.0956	-0.0048	0.1054	78.4419	-49.4845	91.8277
15	0.7004	-0.5882	0.2764	-0.6566	0.1099	-0.1833	-0.0444	-0.1339	-0.0519	-0.2649	0.0702	0.1621	0.0576	0.0301	-0.0258	0.0752	0.0068	-0.0127	0.0979	-0.0069	0.139	69.0559	-53.9111	99.8272
16	-0.5383	1.5629	1.337	0.9897	0.0065	1.667	-0.0506	-0.2937	0.269	-0.1368	0.2766	-0.134	0.1325	-0.1364	-0.226	0.1274	-0.013	-0.0378	0.0853	-0.0136	0.0935	60.0872	-52.3111	83.725
17	13.0459	-5.3007	-10.9613	11.0195	7.6467	27.3218	0.2555	1.0971	-0.4963	-0.4113	-0.8023	-0.119	0.7293	-1.5207	0.5468	0.0633	0.0046	0.0005	0.0672	0.0095	0.0746	77.1674	-51.9254	59.7355
18	3.0753	-1.0822	-0.3413	0.9912	-0.5399	0.4226	0.08	-0.1861	0.2183	0.0897	0.0756	-0.0423	0.1865	-0.146	-0.1556	0.1476	-0.0244	-0.0422	0.1073	-0.0122	0.0737	54.0543	-53.0134	77.4336
19	3.5074	-2.2544	0.2511	4.475	-1.1112	2.0423	0.2578	0.1108	-0.5983	-0.3339	0.0993	0.502	0.1678	-0.2731	-0.3572	0.1746	0.0347	-0.0129	0.0799	-0.0205	0.0889	66.5815	-66.0621	65.4029
20	36.6233	11.3417	-5.0982	5.1677	-0.6708	17.8972	0.261	1.4577	-0.2617	0.151	-0.0698	-0.8811	-0.5153	1.4506	-0.1913	0.142	0.0392	-0.0061	0.1009	-0.0373	0.1026	69.6078	-66.7974	62.213
21	3.5022	-0.3572	-0.3051	1.8611	0.2805	0.4644	-0.1375	0.177	0.0856	0.0301	0.0071	0.1604	0.0125	0.0871	0.1305	0.1105	0.0165	-0.0221	0.0819	0.001	0.067	98.582	-46.8596	114.3075
22	10.1865	0.3066	-6.6216	1.0878	0.9226	4.2831	0.0165	-1.093	-0.3302	-0.1274	-0.0288	-0.2031	-0.1428	0.5905	0.0123	0.1508	0.0131	-0.0339	0.1235	-0.0069	0.0721	103.6364	-39.0441	116.8343
23	5.5145	1.3129	-0.9846	3.6048	0.7757	-0.288	-0.2507	0.3028	-0.4029	-0.067	0.1934	-0.1532	-0.0654	0.0669	0.0572	0.1377	0.0119	-0.0452	0.1106	-0.0149	0.0707	98.9896	-43.8617	109.3093
24	-0.6715	-0.5585	-0.1275	6.4658	-4.5012	7.8653	-0.0124	0.0404	-0.3426	-0.6793	-0.0766	-0.182	-0.6038	-0.3288	0.089	0.0874	0.0348	0.0312	0.2454	-0.1332	0.3062	78.5918	-28.1875	100.1307
25	1.7607	-0.1503	-1.0603	-0.0218	0.3092	0.3848	0.0175	0.0817	0.1932	0.0159	0.048	0.1106	0.0014	-0.125	-0.0654	0.1188	-0.0118	-0.0002	0.0832	-0.0123	0.0916	94.881	-35.8622	105.0029
26	0.6788	-0.2188	0.3347	-0.0898	-0.3699	0.79	-0.0229	-0.0164	0.1319	-0.0342	0.0385	-0.0497	-0.0405	0.0026	-0.0156	0.1168	0.0072	0.0228	0.0038	-0.0146	0.0808	79.9942	-41.8784	100.8459
27	7.1878	3.8618	-2.0721	4.3913	0.0212	0.5299	0.1597	-0.2864	-0.1226	0.2474	-0.3938	0.2079	0.0838	0.0179	0.2341	0.1228	0.0203	0.0206	0.0602	-0.0235	0.0794	65.4873	-30.6563	99.0712
28	7.279	-3.7816	-3.6711	2.1886	1.7944	1.2881	-0.3623	-0.8707	0.0667	0.2382	0.4779	0.0582	0.3037	0.661	-0.1156	0.1203	-0.0079	0.0239	0.0746	-0.0125	0.1075	66.5488	-19.7145	110.4682
29	2.351	-0.671	1.2162	-0.0012	-0.114	0.7522	0.2252	-0.4984	0.0776	0.1002	-0.0824	0.0743	0.0642	-0.2614	-0.1428	0.2126	-0.0918	-0.0065	0.1352	-0.0341	0.1626	78.8975	-41.3638	98.2506
30	6.8282	-0.7028	-1.5144	0.8854	2.1861	-1.9839	0.0899	-0.5637	-0.2415	-0.2463	-0.0232	-0.1405	-0.1625	-0.1212	-0.0667	0.1291	-0.006	-0.0051	0.0695	-0.017	0.1031	88.9498	-33.8856	91.8956
31	4.9399	-0.4493	-1.8988	1.8807	-5.8756	2.942	0.0333	0.2688	-0.072	0.0001	0.1317	-0.0334	-0.59	-0.2414	-0.165	0.078	0.009	-0.0073	0.0651	-0.0081	0.0728	95.647	-33.9025	84.7257
32	3.5753	0.7461	-1.5275	2.1025	-0.6063	0.7823	0.0204	-0.3547	-0.2895	0.2045	0.0076	0.1598	-0.0236	0.2766	-0.028	0.1208	0.0539	-0.016	0.0888	0.0103	0.0934	86.8593	-52.3513	94.0165
33	0.8592	0.1411	0.1052	-1.3986	0.2217	-0.087	-0.0397	0.2145	0.1498	0.3021	0.24	0.1502	0.0527	-0.0639	-0.2002	0.0951	0.0032	-0.0207	0.0997	-0.0445	0.1136	100.1011	-40.8362	74.6031
34	5.0849	7.4449	-0.8044	30.6038	-6.9632	0.643	-0.1132	-0.2278	0.3272	-0.0177	-0.0133	-0.4945	0.0336	0.0424	0.1265	0.0764	0.0192	-0.0004	0.0933	-0.0006	0.0588	99.6815	-42.1584	102.1069
35	5.9578	6.807	-7.0284	10.0585	-8.3657	8.1545	0.1569	0.4901	0.121	-0.1247	0.0651	-0.1745	-0.223	-0.2566	-0.2221	0.1694	0.1037	-0.1007	0.2422	-0.0576	0.1699	111.0863	-27.4318	91.0484
36	1.0439	-5.0355	-3.8866	0.4031	-1.5661	16.1863	0.3271	0.4372	0.0631	0.2888	-0.5576	0.0212	0.279	0.2714	0.2306	0.0935	0.0168	-0.0489	0.0944	-0.0239	0.1259	94.4205	-61.6276	113.9825
37	2.1018	1.739	-2.3011	2.0279	-0.2959	0.0099	-0.3157	-0.1464	-0.3865	0.1875	-0.3452	-0.4874	-0.0223	0.3024	0.6609	0.1184	0.0495	0.0085	0.1106	-0.0022	0.1315	98.9893	-58.4684	118.0542
38	-0.1709	2.3313	-2.1724	20.7318	-3.5711	1.3958	0.0933	0.3982	-0.2643	1.4233	-0.7658	-0.3321	-0.0611	0.6469	0.6725	0.0884	0.0571	-0.0053	0.2045	-0.0873	0.2354	112.8925	-61.5582	115.349
39	0.9053	2.5265	0.7033	4.9876	1.3335	0.8248	0.1045	-0.0149	-0.1429	0.0461	-0.0465	-0.2733	0.2109	0.0868	-0.058	0.1021	0.0583	-0.0186	0.0801	0.0039	0.0678	104.1052	-58.6858	108.3654
40	2.4643	3.7096	0.0228	4.2745	0.053	0.5583	0.2748	0.1596	-0.2343	0.306	-0.29	-0.0857	0.0948	-0.0484	0.0152	0.1477	0.0926	0.0035	0.1122	0.003	0.085	98.7826	-67.7041	112.54
41	2.1853	0.8417	-0.3875	-0.808	-0.2923	2.1638	0.0676	-0.1334	-0.2052	-0.3333	-0.2142	0.1326	0.067	0.4695	0.1466	0.0958	0.0211	-0.009	0.1197	0.0054	0.0707	102.9664	-38.9126	133.3018
42	0.5577	-0.0432	2.7075	-0.1305	-0.9325	3.436	0.0685	-0.0971	-0.0483	-0.2188	-0.0959	-0.0808	-0.1117	-0.575	0.0273	0.0855	0.0271	-0.0053	0.0832	-0.0194	0.1003	94.6713	-35.9628	140.1631
43	2.6964	-0.9911	1.0239	2.6063	1.0611	-1.1714	-0.3271	0.5215	0.4894	-0.4053	0.3907	-0.1885	0.1236	-0.03	-0.0636	0.1543	0.0144	-0.0386	0.1704	0.015	0.0795	117.6038	-34.1204	125.2723
44	1.7188	-1.5845	-0.3446	5.5753	-0.0264	1.1043	-0.1333	-0.0096	-0.109	-0.1599	0.1034	0.5083	0.1601	-0.0303	0.0299	0.1142	0.0035	-0.0811	0.1002	-0.0087	0.0848	105.1154	-42.1578	132.798
45	-6.1543	7.6649	-5.9371	32.9005	-14.4093	25.1714	0.796	-0.4912	-1.2698	0.266	-0.6444	-0.7195	0.1475	1.7461	-0.1515	0.0878	0.0122	-0.0103	0.0632	-0.0062	0.0814	113.4025	-56.9642	133.1457
46	0.1257	0.294	0.3106	-0.1412	-0.1991	-0.2802	-0.0975	-0.0965	0.1026	0.0347	0.0383	-0.1362	-0.0036	0.0408	0.0592	0.1554	0.0466	-0.0249	0.1022	-0.0063	0.0817	104.9348	-40.3501	140.6232
47	2.3326	-0.3349	-1.3827	2.4066	-0.4312	3.4421	0.066	0.2749	0.3125	-0.3735	-0.0847	-0.1703	-0.3051	-0.0187	0.0187	0.1449	0.0156	-0.0906	0.0704	-0.0128	0.1434	112.4757	-31.7023	146.2326
48	1.2046	-0.709	0.0583	4.422	-1.0016	0.8855	-0.0414	0.191	-0.2639	0.1226	-0.0158	0.5063	-0.0407	0.1173	0.0572	0.0613	0.0272	0.0238	0.0836	0.0004	0.0645	127.244	-50.7388	147.7796
49	4.0954	2.5812	-0.2406	-1.3173	0.3668	3.6651	-0.4019	0.3224	0.0754	0.1361	0.294	-0.232	-0.1767	0.5565	0.1079	0.1551	-0.0661	-0.0394	0.1117	-0.0083	0.1112	124.2838	-26.6388	147.5458
50	1.3651	-0.2538	-0.9355	2.6788	-0.0593	0.6598	-0.442	0.0933	0.1359	-0.1412	0.1065	-0.4108	0.1012	0.0963	0.3355	0.106	-0.0664	0.0256	0.1154	0.0039	0.0626	123.9348	-33.8859	151.8046
51	2.1287	0.8822	-3.0862	-3.0603	-3.1284	1.1355	-1.0278	-0.3334	-0.1041	0.3451	-0.1102	0.1	-0.0156	0.3659	1.138	0.0896	-0.0444	-0.0021	0.1491	0.0101	0.1114	123.1076	-28.1343	153.3479
52	14.3984	0.0728	-7.6439	-1.8471	-1.886	6.4198	-0.8422	0.7689	-1.3033	0.1497	-0.4991	0.4611	0.4089	0.0233	1.3413	0.0953	-0.0552	-0.0418	0.15	0.058	0.1292	129.4351	-38.3403	151.0802
53	0.3219	0.1971	-0.123	1.0386	0.1024	2.2292	-0.0969	-0.0049	0.0717	-0.1543	0.0384	-0.183	-0.1873	0.1107	0.0584	0.1764	-0.0021	-0.0737	0.1027	0.012	0.1034	118.8602	-35.6004	150.21
54	2.9669	-2.4049	2.8462	-5.0288	6.5658	-3.1736	-0.2075	-0.0628	0.3207	-0.2458	0.0704	-0.0905	0.3668	0.3274	0.1372	0.1135	0.0556	-0.0867	0.121	-0.0027	0.1136	109.9149	-27.9186	141.5385
55	19.6613	7.0321	-10.6505	17.1447	0.7844	12.6759	-0.8928	1.7548	0.3243	-0.4405	1.0781	0.3718	0.5105	-1.1948	-0.1853	0.0889	0.0127	0.0177	0.0712	-0.0097	0.078	91.1828	-53.3423	137.4545
56	0.5977	-0.2811	-1.8366	5.519	-1.8848	0.5729	0.0065	0.0859	0.1978	0.2998	0.183	-0.1267	0.0643	-0.1764	-0.1895	0.0817	0.0348	-0.0519	0.1075	-0.0134	0.1032	97.3578	-33.5729	138.7115
57	1.5685	2.4867	-2.1671	2.0383	-1.2431	2.7238	-0.1352	0.0047	0.0995	-0.0205	0.0972	0.124	-0.2486	-0.2473	0.0381	0.1244	0.041	-0.0408	0.0853	-0.026	0.1087	92.2632	-27.4434	138.9997
58	2.1564	1.2002	2.4703	-7.2575	-0.221	5.2715	-0.2134	-0.6452	1.1567	0.0952	0.0808	-1.1053	-0.0372	-0.9644	0.1327	0.1368	-0.045	0.0744	0.1302	-0.0701	0.1482	74.9469	-28.5294	147.1194
59	4.4423	0.3399	-0.026	3.2336	0.6071	0.7584	-0.0036	0.3549	0.5536	0.095	0.1743	-0.4689	-0.1374	-0.1738	-0.1707	0.1562	0.071	-0.0781	0.1497	-0.1355	0.2836	91.9962	-38.9578	138.914
60	7.6505	3.7255	3.063	8.4311	-2.7111	4.4371	0.2158	-0.4468	-1.0668	-0.217	-0.18	-0.3278	0.1982	-0.5682	-0.0358	0.0786	-0.0373	0.0204	0.1884	-0.0157	0.0944	84.7211	-36.5367	144.1242
61	2.4944	-0.4743	-3.3743	5.2327	-4.5648	0.9733	0.4182	-0.246	0.1815	-0.3988	-0.1929	-0.5409	0.5089	-0.2039	-0.2253	0.1073	0.0148	-0.0625	0.1434	-0.0582	0.1565	138.1853	-50.386	180.2916
62	1.9054	1.8321	1.759	12.024	-4.7829	4.0248	0.3929	-0.3683	-0.2671	-0.4517	-0.3093	-0.3081	0.1931	-0.0495	-0.0835	0.0717	0.0012	-0.0452	0.1575	-0.0146	0.05	129.7416	-49.3132	189.4451
63	2.4515	2.8877	-1.2305	0.8268	0.9552	-1.1693	-0.1981	0.2606	0.4086	0.0655	-0.0931	0.2001	-0.2716	0.2956	0.2912	0.1041	0.0585	-0.04	0.1372	-0.0381	0.0855	130.1194	-48.0433	179.6151
64	1.317	-1.394	-1.2656	6.2311	-3.7351	2.6713	-0.2962	-0.1739	-0.1383	0.1988	0.5078	0.7734	-0.1482	0.2876	-0.2116	0.0991	-0.0038	-0.0306	0.1078	0.0003	0.0754	132.7678	-49.6129	180.2558
65	25.5254	9.2171	9.1998	-1.757	4.8236	14.2642	-0.0167	0.7297	0.0531	0.4433	-0.5337	-0.7187	-0.1724	-1.3156	0.5504	0.2045	-0.0142	0.0232	0.1591	0.0564	0.0979	127.4126	-32.7596	163.3657
66	0.1106	0.9826	0.8516	-0.9658	-0.4372	0.6602	-0.0324	0.1512	0.0283	0.0078	0.066	-0.0362	0.1094	0.0169	-0.0335	0.1401	-0.0178	-0.0512	0.1163	-0.01	0.0954	129.9983	-53.8594	168.6897
67	-0.0863	-1.4453	2.4504	1.7936	1.0014	-0.8839	-0.0102	0.3399	0.81	-0.385	0.08	-0.3935	0.0478	0.1493	-0.0698	0.2426	0.1104	-0.077	0.1721	0.0635	0.3511	118.3514	-43.2553	157.0764
68	0.4796	0.3375	-1.9161	0.8005	-2.6402	3.2062	0.0036	0.1059	0.0934	0.2507	0.0045	0.0829	-0.2355	0.0025	-0.0081	0.1264	-0.0201	-0.0213	0.0967	-0.0443	0.0895	123.6573	-47.1956	162.0071
69	2.4916	-2.8619	-1.3854	5.2021	1.169	-0.2701	0.0635	-0.1447	0.1001	-0.2298	-0.2213	-0.329	-0.0228	0.1922	0.1578	0.0738	-0.0341	-0.0024	0.1374	0.0042	0.0647	136.7096	-42.9415	141.2842
70	2.0194	1.2217	-0.7445	-2.311	1.8632	-1.5235	0.0542	-0.0688	-0.1118	-0.1223	-0.6165	-0.1886	0.0385	0.5803	0.5623	0.0714	-0.0158	0.0021	0.0844	-0.0167	0.0953	129.7223	-45.6768	150.2081
71	11.0856	5.7556	-7.5759	11.4275	-2.9208	6.374	0.1031	-0.8051	0.1894	-0.662	-0.0146	-0.4175	0.0638	0.7016	-0.0884	0.0941	0.021	-0.0308	0.1194	-0.0345	0.0858	133.0528	-54.3035	153.1871
72	1.9954	-2.5148	2.5808	1.0906	3.3538	14.5206	-0.3357	0.0157	-0.0556	-0.1771	0.082	-0.0253	-0.6425	0.6581	0.2537	0.0744	-0.0056	-0.0149	0.0789	-0.0028	0.0849	123.809	-60.6715	159.4746
73	0.8361	-0.22	0.3176	1.4207	-1.0187	1.966	-0.0229	0.0081	0.0492	-0.1245	0.0279	0.1251	0.2173	-0.1161	-0.005	0.0866	0.0165	-0.0482	0.0746	-0.023	0.1198	115.3529	-50.2955	154.6875
74	0.5819	0.3882	-0.6112	0.8697	-0.6954	3.2167	-0.0186	-0.0627	-0.027	-0.2047	-0.0169	-0.0678	-0.4247	0.6333	0.0355	0.2197	-0.0635	0.0098	0.1919	-0.0421	0.097	134.0935	-47.4782	143.7121
75	5.9474	1.5377	-4.1405	1.9599	-1.6774	20.4623	0.011	0.0839	0.4928	-0.1715	-0.0163	0.4232	-0.9517	0.5047	0.0054	0.0884	0.0298	-0.0275	0.0739	-0.0228	0.0893	109.1747	-45.0025	161.0741
76	-0.5876	-0.7568	0.3413	1.1416	-0.22	0.1601	0.178	-0.2434	-0.038	-0.0342	-0.1959	0.0307	-0.0219	-0.0763	0.0179	0.1015	0.0252	-0.022	0.0957	-0.0006	0.0965	111.5744	-55.8803	160.537
77	6.0734	0.2529	-4.0149	-2.8896	2.1752	3.9436	0.6422	-0.4748	0.2076	-0.5033	-0.136	-0.0722	-0.2039	0.3406	-0.5061	0.1097	-0.0467	0.0006	0.1281	0.0269	0.1014	127.1813	-51.4563	176.1451
78	0.217	0.6511	0.0018	24.7974	8.1891	3.133	0.0355	-0.1614	-0.1875	-0.1875	-0.2419	0.3881	0.2745	-0.2817	0.2064	0.2414	-0.0538	-0.0587	0.4604	0.1772	0.145	127.8415	-79.3484	165.3636
79	1.4956	-0.8812	0.2805	0.88	-0.2478	0.3325	0.1373	-0.1468	-0.0146	0.0436	-0.205	-0.1329	0.0543	-0.1838	0.0676	0.0917	0.0107	-0.0246	0.1262	0.0016	0.0663	125.182	-51.7461	182.4143
80	1.0544	-0.3308	-2.1177	1.0973	0.6097	0.9144	-0.2566	-0.4007	0.2553	0.0711	0.034	-0.3346	-0.1267	-0.3903	0.2226	0.0799	-0.0383	0.0284	0.1655	-0.0401	0.1119	117.4062	-41.2066	187.9513
81	1.0847	-0.6325	-1.3368	1.8089	-0.5346	1.9914	-0.1743	0.1011	-0.2633	0.177	0.1447	0.1914	0.0689	0.0418	0.0297	0.1096	-0.037	-0.0581	0.1329	0.0324	0.1421	147.8836	-48.4761	194.6334
82	7.7018	2.4919	-0.6413	-0.8291	0.6369	3.1183	-0.0059	-0.1792	0.8202	-0.5479	0.3224	0.6686	-0.2632	-0.2138	-0.3165	0.1021	0.0124	-0.0508	0.1193	0.0081	0.1083	150.2999	-39.3029	184.2233
83	3.0099	-2.1293	-2.344	2.5321	0.716	3.6912	0.3959	-0.2275	0.1931	-0.1015	-0.157	-0.5566	-0.153	0.0625	-0.2389	0.1011	-0.0407	-0.0353	0.122	0.014	0.0763	152.7625	-46.5021	192.5044
84	13.3059	-6.5591	4.6411	6.9615	-3.207	8.9651	-0.121	-0.2082	-0.6876	0.5655	-0.0251	-0.367	0.8017	0.8658	0.1461	0.2372	-0.069	0.0891	0.3026	-0.0503	0.1049	147.6724	-51.8716	212.1342
85	8.4194	-2.641	-3.1594	-0.3443	-0.1513	0.1704	0.1971	-0.417	-0.1899	-0.1347	-0.2432	0.078	0.0316	-0.2224	0.0461	0.1331	-0.0349	-0.0344	0.0899	0.0179	0.0743	155.3512	-51.9936	200.2914
86	8.5567	7.6666	0.5736	17.7996	2.9068	4.1311	0.4751	0.0025	0.0752	0.9849	-0.9511	1.5036	-0.5022	-0.9572	0.476	0.1734	0.0896	0.0085	0.253	-0.0674	0.1071	156.6819	-40.8442	200.1238
87	7.0399	-7.112	0.6194	20.1833	3.6604	5.2339	0.1743	-1.2794	0.4535	-0.3083	-0.0265	1.1522	-0.9978	-0.1491	-0.1478	0.1244	-0.0518	-0.031	0.1212	-0.0096	0.1254	163.8449	-22.3184	211.3191
88	1.5459	0.7817	-0.5239	0.4038	-0.2061	1.7583	-0.111	0.2789	-0.0853	-0.2179	0.055	0.0976	0.0655	-0.09	0.0559	0.1111	-0.0268	0.0087	0.1126	0.0359	0.0607	161.5115	-47.651	206.2002
89	0.282	2.8293	1.7005	16.274	0.7654	5.9973	0.1559	-0.2502	0.4264	-0.8328	-0.5008	0.6668	-0.15	-0.447	0.345	0.0983	-0.0578	-0.0195	0.1484	0.0002	0.1214	150.5511	-65.7089	217.9951
90	-0.6099	0.7198	-0.8503	4.2323	1.2933	0.6921	0.0299	-0.2027	-0.0255	-0.4328	-0.0482	0.4307	-0.1282	-0.3714	0.0184	0.1178	-0.0504	-0.043	0.1543	-0.0135	0.1464	146.0348	-46.0055	224.4448
91	4.1475	1.719	-0.7	0.3827	-1.1977	1.3439	0.0649	-0.1317	-0.1317	-0.0808	0.0626	0.0069	-0.0465	-0.0655	-0.1276	0.0901	-0.0203	-0.018	0.0909	0.0175	0.0959	159.7249	-56.4694	213.4124
92	0.8934	0.4379	-3.7711	1.7338	2.8341	8.5597	0.1644	-0.0329	0.1403	-0.0831	-0.1375	0.1961	-0.2254	-0.0198	-0.0269	0.0833	-0.0138	-0.0409	0.0935	0.0478	0.116	167.0475	-51.5388	218.8873
93	28.2578	2.8735	-8.0212	-7.3266	-4.5615	9.4833	0.0538	1.4433	-0.3372	-0.0967	0.5984	-1.0854	0.2084	-1.0449	-0.6522	0.0842	0.0045	0.0074	0.0585	-0.0016	0.0753	168.889	-60.8039	204.1988
94	1.1864	-1.0511	0.3549	1.1374	0.4252	0.9816	-0.3254	-0.0763	-0.2763	0.1243	0.078	0.1518	-0.249	-0.0855	0.2474	0.1555	-0.0385	-0.0226	0.1149	0.0389	0.0884	161.29	-40.7441	213.9467
95	2.8903	2.9945	-2.6632	1.669	-2.2342	-1.3587	-0.398	0.2134	-0.3254	-0.548	-0.1201	-0.2879	-0.3703	0.2903	0.5181	0.073	0.0133	-0.0147	0.117	-0.0362	0.0841	159.6577	-47.2951	212.0139
96	-0.6564	14.0289	2.1749	9.0108	-1.658	4.1465	-0.8114	0.2763	0.0586	0.3186	1.0878	0.6167	0.2154	0.4919	-0.2764	0.0677	0.005	-0.007	0.1406	0.0062	0.072	162.2283	-46.8399	196.1349
97	10.2922	-13.4914	-0.0382	22.2618	0.7335	0.6204	0.0653	-0.3134	-0.3323	0.1216	0.037	-0.7992	0.1349	0.0453	-0.1023	0.1874	-0.1661	-0.0199	0.2935	0.0761	0.1982	165.0762	-57.5832	196.7071
98	-0.053	0.8676	-0.1484	0.4198	-0.6846	-0.069	-0.0536	0.2469	-0.0122	-0.1234	-0.0405	-0.0535	-0.2514	0.0664	0.0941	0.1043	-0.0707	-0.0313	0.1582	0.0328	0.0735	154.7848	-41.926	189.3134
99	4.0677	-5.3721	-0.3317	10.2557	2.9987	13.4271	-0.2682	0.6984	-0.4708	0.0219	-0.4991	0.6781	-1.2542	-1.367	0.7673	0.1141	-0.0072	0.0001	0.0616	0.0175	0.1112	156.4736	-22.7927	189.6568
100	1.3659	0.4359	3.0195	4.169	2.7536	3.6085	0.0814	0.2203	0.3476	-0.6867	-0.7038	0.5973	-1.1424	-0.4238	0.6224	0.1239	-0.012	-0.0435	0.1443	0.0868	0.165	155.9161	-26.1424	186.9043
101	1.9818	0.201	0.1149	1.4505	0.4992	0.5887	0.0843	0.0485	-0.2445	-0.1267	-0.1528	0.1274	-0.0313	-0.153	0.0685	0.1121	-0.0113	-0.0396	0.1053	0.01	0.0845	173.8245	-40.8382	244.8155
102	-0.8561	5.1696	-0.47	7.5629	1.3318	4.3552	-0.2513	-0.0362	-0.222	-0.4538	0.3026	0.1037	0.0201	-0.088	-0.0514	0.0821	0.0044	0.023	0.0883	-0.0133	0.0861	180.0264	-30.8303	239.1838
103	2.9499	1.7739	0.9042	0.6594	2.7078	1.1498	-0.0065	0.2494	-0.1423	0.4085	0.2407	-0.1753	0.0132	0.3024	-0.2341	0.1076	0.0027	-0.0602	0.1276	-0.016	0.113	178.8967	-36.1111	246.5378
104	-0.0085	0.0021	0.5197	3.2526	0.8462	0.9188	-0.2823	0.1565	0.0313	-0.6537	0.0579	-0.2911	-0.301	0.0734	0.2244	0.2054	-0.0529	-0.1026	0.1048	0.0895	0.1484	174.296	-20.3994	235.7709
105	6.3374	-4.6584	-2.1053	6.8136	2.6185	-0.162	-0.1176	-0.5571	0.4849	0.6876	0.2113	0.2422	0.4594	0.2627	-0.0937	0.2691	-0.1192	0.0304	0.158	-0.006	0.1532	158.7096	-40.6543	246.297
106	6.1931	3.1752	-3.5973	0.9401	-1.7077	3.1119	-0.6745	0.0155	-0.6901	-0.4091	0.0621	-0.6347	0.3555	-0.2669	0.6124	0.1129	0.0252	-0.0204	0.0896	-0.0247	0.1039	154.4776	-43.2063	241.7926
107	21.3181	1.3802	-2.9284	4.1602	0.9201	14.8807	0.0446	1.0251	-1.266	-0.4329	-0.207	-1.06	-0.0014	0.9897	0.1624	0.1077	-0.0345	0.0089	0.1094	0.0381	0.1214	172.589	-29.7946	210.4512
108	-0.0636	0.295	0.2443	-0.5981	-0.213	1.0442	-0.0201	-0.0712	-0.0495	0.063	0.0253	0.1261	-0.0567	-0.0471	-0.0052	0.092	-0.0383	-0.0233	0.0679	0.0019	0.0885	160.1738	-42.3949	225.3067
109	11.0145	-5.4865	-12.6328	4.6064	4.3944	15.1886	0.8517	0.1311	0.8796	-0.9078	-0.0305	-0.2692	-0.1259	-0.2221	-0.8212	0.1626	-0.0158	-0.0951	0.144	0.0414	0.1379	152.5947	-61.2424	213.4109
110	0.8066	-2.0736	-5.1581	3.492	6.0087	10.9405	-0.0687	-0.0848	-0.3537	0.2006	0.138	0.2326	0.1468	0.356	-0.0693	0.0856	-0.0308	-0.0425	0.1053	0.0205	0.1207	151.6705	-53.3084	230.8335
111	1.4419	1.7	-0.6909	8.008	-2.7309	1.3414	-0.1816	-0.2212	-0.1222	-0.7998	0.138	-0.0078	0.3666	-0.1733	0.0436	0.0955	0.0238	-0.0342	0.1537	0.0072	0.0987	153.2218	-39.2395	227.3674
112	0.7806	-1.9241	1.2693	1.6269	0.9218	3.4612	0.1703	0.2649	0.2721	-0.3056	-0.0722	-0.0181	0.0846	-0.1403	-0.0981	0.0905	-0.0274	-0.0079	0.0935	0.056	0.0986	150.9019	-41.1128	218.1576
113	-0.2337	-0.312	-0.2261	0.3671	0.9356	1.8902	0.2823	-0.2297	0.3457	-0.0976	0.2235	-0.1987	-0.2123	0.7678	-0.5058	0.3048	-0.1182	-0.2007	0.1852	0.106	0.2263	198.485	-46.3706	186.7152
114	2.0733	0.3141	-0.1633	1.6547	0.3266	-0.8465	-0.1064	0.1477	0.0777	0.02	-0.0671	0.2882	-0.0129	0.1155	0.1736	0.1781	-0.0633	-0.042	0.1037	0.0109	0.0704	153.2318	-31.2756	224.0114
115	7.3718	-0.016	-3.1849	0.6647	-0.5807	1.7942	0.336	0.2749	-0.3398	-0.1198	-0.2536	0.0312	-0.5258	-0.4024	-0.0824	0.1174	-0.0251	-0.0304	0.0805	0.005	0.0826	164.0786	-32.8876	236.2761
116	40.2302	-1.8543	-1.5845	9.8232	-11.8258	16.0047	-0.1941	-1.3794	1.6736	-0.256	1.1406	0.2886	-0.1448	-2.0479	-0.9464	0.132	-0.0344	-0.0133	0.0888	-0.02	0.0949	179.5838	-42.4857	234.3096
117	19.0282	-11.4682	1.7046	9.7778	-1.6769	1.1842	0.8141	-2.2961	0.5884	-1.346	0.3929	0.5124	-0.0471	-0.4563	-1.207	0.319	-0.2437	0.0427	0.2899	-0.0313	0.2428	162.4377	-18.9652	233.0075
118	1.5498	0.6945	-0.8695	0.3564	-0.14	0.3751	-0.1075	0.1146	-0.2608	0.0566	-0.0209	-0.0656	-0.0853	0.0012	0.1283	0.1154	-0.0218	-0.0733	0.1115	0.0226	0.1234	178.8085	-35.8314	237.2739
119	4.0395	1.4922	-1.7134	4.3596	1.7269	6.2899	-0.1187	0.4212	-0.1806	-0.1497	0.2617	-0.1363	0.1831	-0.2031	-0.143	0.08	-0.0482	-0.017	0.0775	-0.0107	0.0879	186.7182	-25.072	221.6414
120	4.159	-1.376	-3.2626	0.4152	0.4928	2.4835	-0.2737	0.1275	0.0259	-0.0959	0.2189	-0.1338	0.0885	0.161	0.0548	0.1107	-0.0299	-0.0458	0.1081	0.0333	0.1256	187.6609	-28.1772	231.954

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Auth asym-ID	Label asym-ID	Auth seq-ID	Label seq-ID
1	X-RAY DIFFRACTION	1	A	A	3 - 29	17 - 43
2	X-RAY DIFFRACTION	2	A	A	30 - 58	44 - 72
3	X-RAY DIFFRACTION	3	A	A	59 - 80	73 - 94
4	X-RAY DIFFRACTION	4	A	A	81 - 109	95 - 123
5	X-RAY DIFFRACTION	5	A	A	110 - 124	124 - 138
6	X-RAY DIFFRACTION	6	A	A	125 - 139	139 - 153
7	X-RAY DIFFRACTION	7	A	A	140 - 170	154 - 184
8	X-RAY DIFFRACTION	8	A	A	171 - 182	185 - 196
9	X-RAY DIFFRACTION	9	A	A	183 - 193	197 - 207
10	X-RAY DIFFRACTION	10	A	A	194 - 212	208 - 226
11	X-RAY DIFFRACTION	11	A	A	213 - 230	227 - 244
12	X-RAY DIFFRACTION	12	A	A	231 - 246	245 - 260
13	X-RAY DIFFRACTION	13	A	A	247 - 252	261 - 266
14	X-RAY DIFFRACTION	14	A	A	253 - 265	267 - 279
15	X-RAY DIFFRACTION	15	A	A	266 - 292	280 - 306
16	X-RAY DIFFRACTION	16	A	A	293 - 312	307 - 326
17	X-RAY DIFFRACTION	17	A	A	313 - 327	327 - 341
18	X-RAY DIFFRACTION	18	A	A	328 - 367	342 - 381
19	X-RAY DIFFRACTION	19	A	A	368 - 402	382 - 416
20	X-RAY DIFFRACTION	20	A	A	403 - 409	417 - 423
21	X-RAY DIFFRACTION	21	B	B	4 - 42	18 - 56
22	X-RAY DIFFRACTION	22	B	B	43 - 58	57 - 72
23	X-RAY DIFFRACTION	23	B	B	59 - 79	73 - 93
24	X-RAY DIFFRACTION	24	B	B	80 - 92	94 - 106
25	X-RAY DIFFRACTION	25	B	B	93 - 111	107 - 125
26	X-RAY DIFFRACTION	26	B	B	112 - 154	126 - 168
27	X-RAY DIFFRACTION	27	B	B	155 - 182	169 - 196
28	X-RAY DIFFRACTION	28	B	B	183 - 205	197 - 219
29	X-RAY DIFFRACTION	29	B	B	206 - 219	220 - 233
30	X-RAY DIFFRACTION	30	B	B	220 - 228	234 - 242
31	X-RAY DIFFRACTION	31	B	B	229 - 237	243 - 251
32	X-RAY DIFFRACTION	32	B	B	238 - 264	252 - 278
33	X-RAY DIFFRACTION	33	B	B	265 - 291	279 - 305
34	X-RAY DIFFRACTION	34	B	B	292 - 300	306 - 314
35	X-RAY DIFFRACTION	35	B	B	301 - 322	315 - 336
36	X-RAY DIFFRACTION	36	B	B	323 - 331	337 - 345
37	X-RAY DIFFRACTION	37	B	B	332 - 346	346 - 360
38	X-RAY DIFFRACTION	38	B	B	347 - 356	361 - 370
39	X-RAY DIFFRACTION	39	B	B	357 - 385	371 - 399
40	X-RAY DIFFRACTION	40	B	B	386 - 411	400 - 425
41	X-RAY DIFFRACTION	41	C	C	3 - 23	17 - 37
42	X-RAY DIFFRACTION	42	C	C	24 - 41	38 - 55
43	X-RAY DIFFRACTION	43	C	C	42 - 54	56 - 68
44	X-RAY DIFFRACTION	44	C	C	55 - 81	69 - 95
45	X-RAY DIFFRACTION	45	C	C	82 - 91	96 - 105
46	X-RAY DIFFRACTION	46	C	C	92 - 116	106 - 130
47	X-RAY DIFFRACTION	47	C	C	117 - 134	131 - 148
48	X-RAY DIFFRACTION	48	C	C	135 - 192	149 - 206
49	X-RAY DIFFRACTION	49	C	C	193 - 213	207 - 227
50	X-RAY DIFFRACTION	50	C	C	214 - 241	228 - 255
51	X-RAY DIFFRACTION	51	C	C	242 - 250	256 - 264
52	X-RAY DIFFRACTION	52	C	C	251 - 262	265 - 276
53	X-RAY DIFFRACTION	53	C	C	263 - 292	277 - 306
54	X-RAY DIFFRACTION	54	C	C	293 - 312	307 - 326
55	X-RAY DIFFRACTION	55	C	C	313 - 327	327 - 341
56	X-RAY DIFFRACTION	56	C	C	328 - 343	342 - 357
57	X-RAY DIFFRACTION	57	C	C	344 - 370	358 - 384
58	X-RAY DIFFRACTION	58	C	C	371 - 384	385 - 398
59	X-RAY DIFFRACTION	59	C	C	385 - 398	399 - 412
60	X-RAY DIFFRACTION	60	C	C	399 - 412	413 - 426
61	X-RAY DIFFRACTION	61	D	D	1 - 15	15 - 29
62	X-RAY DIFFRACTION	62	D	D	16 - 36	30 - 50
63	X-RAY DIFFRACTION	63	D	D	37 - 53	51 - 67
64	X-RAY DIFFRACTION	64	D	D	54 - 79	68 - 93
65	X-RAY DIFFRACTION	65	D	D	80 - 92	94 - 106
66	X-RAY DIFFRACTION	66	D	D	93 - 118	107 - 132
67	X-RAY DIFFRACTION	67	D	D	119 - 126	133 - 140
68	X-RAY DIFFRACTION	68	D	D	127 - 146	141 - 160
69	X-RAY DIFFRACTION	69	D	D	147 - 168	161 - 182
70	X-RAY DIFFRACTION	70	D	D	169 - 185	183 - 199
71	X-RAY DIFFRACTION	71	D	D	186 - 195	200 - 209
72	X-RAY DIFFRACTION	72	D	D	196 - 201	210 - 215
73	X-RAY DIFFRACTION	73	D	D	202 - 222	216 - 236
74	X-RAY DIFFRACTION	74	D	D	223 - 253	237 - 267
75	X-RAY DIFFRACTION	75	D	D	254 - 265	268 - 279
76	X-RAY DIFFRACTION	76	D	D	266 - 290	280 - 304
77	X-RAY DIFFRACTION	77	D	D	291 - 303	305 - 317
78	X-RAY DIFFRACTION	78	D	D	304 - 322	318 - 336
79	X-RAY DIFFRACTION	79	D	D	323 - 381	337 - 395
80	X-RAY DIFFRACTION	80	D	D	382 - 412	396 - 426
81	X-RAY DIFFRACTION	81	E	E	3 - 30	17 - 44
82	X-RAY DIFFRACTION	82	E	E	31 - 42	45 - 56
83	X-RAY DIFFRACTION	83	E	E	43 - 78	57 - 92
84	X-RAY DIFFRACTION	84	E	E	79 - 92	93 - 106
85	X-RAY DIFFRACTION	85	E	E	93 - 109	107 - 123
86	X-RAY DIFFRACTION	86	E	E	110 - 120	124 - 134
87	X-RAY DIFFRACTION	87	E	E	121 - 126	135 - 140
88	X-RAY DIFFRACTION	88	E	E	127 - 154	141 - 168
89	X-RAY DIFFRACTION	89	E	E	155 - 167	169 - 181
90	X-RAY DIFFRACTION	90	E	E	168 - 183	182 - 197
91	X-RAY DIFFRACTION	91	E	E	184 - 210	198 - 224
92	X-RAY DIFFRACTION	92	E	E	211 - 230	225 - 244
93	X-RAY DIFFRACTION	93	E	E	231 - 240	245 - 254
94	X-RAY DIFFRACTION	94	E	E	241 - 272	255 - 286
95	X-RAY DIFFRACTION	95	E	E	273 - 291	287 - 305
96	X-RAY DIFFRACTION	96	E	E	292 - 301	306 - 315
97	X-RAY DIFFRACTION	97	E	E	302 - 322	316 - 336
98	X-RAY DIFFRACTION	98	E	E	323 - 366	337 - 380
99	X-RAY DIFFRACTION	99	E	E	367 - 383	381 - 397
100	X-RAY DIFFRACTION	100	E	E	384 - 411	398 - 425
101	X-RAY DIFFRACTION	101	F	F	2 - 21	16 - 35
102	X-RAY DIFFRACTION	102	F	F	22 - 30	36 - 44
103	X-RAY DIFFRACTION	103	F	F	31 - 44	45 - 58
104	X-RAY DIFFRACTION	104	F	F	45 - 78	59 - 92
105	X-RAY DIFFRACTION	105	F	F	79 - 104	93 - 118
106	X-RAY DIFFRACTION	106	F	F	105 - 119	119 - 133
107	X-RAY DIFFRACTION	107	F	F	120 - 127	134 - 141
108	X-RAY DIFFRACTION	108	F	F	128 - 164	142 - 178
109	X-RAY DIFFRACTION	109	F	F	165 - 177	179 - 191
110	X-RAY DIFFRACTION	110	F	F	178 - 188	192 - 202
111	X-RAY DIFFRACTION	111	F	F	189 - 210	203 - 224
112	X-RAY DIFFRACTION	112	F	F	211 - 231	225 - 245
113	X-RAY DIFFRACTION	113	F	F	232 - 266	246 - 280
114	X-RAY DIFFRACTION	114	F	F	267 - 292	281 - 306
115	X-RAY DIFFRACTION	115	F	F	293 - 309	307 - 323
116	X-RAY DIFFRACTION	116	F	F	310 - 320	324 - 334
117	X-RAY DIFFRACTION	117	F	F	321 - 331	335 - 345
118	X-RAY DIFFRACTION	118	F	F	332 - 370	346 - 384
119	X-RAY DIFFRACTION	119	F	F	371 - 388	385 - 402
120	X-RAY DIFFRACTION	120	F	F	389 - 412	403 - 426

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