Entry Database : PDB / ID : 2ns8 Structure visualization Downloads & linksTitle How an in vitro selected peptide mimics the antibiotic tetracycline to induce TET repressor Components16 residue peptide Tip (Transcription inducing peptide) Tetracycline repressor protein DetailsKeywords TRANSCRIPTION / Transcription regulator / helix-turn-helix / bound repressor-inducing peptideFunction / homology Function and homology informationFunction Domain/homology Component
transcription cis-regulatory region binding / DNA-binding transcription factor activity / response to antibiotic / negative regulation of DNA-templated transcription / metal ion binding Similarity search - Function Tetracycline transcriptional regulator, TetR / Tetracycline repressor TetR, C-terminal / Tetracyclin repressor-like, C-terminal domain / DNA-binding HTH domain, TetR-type, conserved site / TetR-type HTH domain signature. / Tetracycline Repressor, domain 2 / Tetracyclin repressor-like, C-terminal domain superfamily / Tetracycline Repressor; domain 2 / Bacterial regulatory proteins, tetR family / DNA-binding HTH domain, TetR-type ... Tetracycline transcriptional regulator, TetR / Tetracycline repressor TetR, C-terminal / Tetracyclin repressor-like, C-terminal domain / DNA-binding HTH domain, TetR-type, conserved site / TetR-type HTH domain signature. / Tetracycline Repressor, domain 2 / Tetracyclin repressor-like, C-terminal domain superfamily / Tetracycline Repressor; domain 2 / Bacterial regulatory proteins, tetR family / DNA-binding HTH domain, TetR-type / TetR-type HTH domain profile. / Homeodomain-like / Homeobox-like domain superfamily / Arc Repressor Mutant, subunit A / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Escherichia coli (E. coli)synthetic construct (others) Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.55 Å DetailsAuthors Luckner, S.R. / Klotzsche, M. / Berens, C. / Hillen, W. / Muller, Y.A. CitationJournal : J.Mol.Biol. / Year : 2007Title : How an agonist peptide mimics the antibiotic tetracycline to induce Tet-repressorAuthors : Luckner, S.R. / Klotzsche, M. / Berens, C. / Hillen, W. / Muller, Y.A. History Deposition Nov 3, 2006 Deposition site : RCSB / Processing site : PDBJRevision 1.0 Jul 24, 2007 Provider : repository / Type : Initial releaseRevision 1.1 May 1, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Advisory / Source and taxonomy / Version format complianceRevision 1.3 Aug 16, 2017 Group : Refinement description / Source and taxonomy / Category : entity_src_gen / softwareRevision 1.4 Aug 23, 2017 Group : Source and taxonomy / Category : pdbx_entity_src_synItem : _pdbx_entity_src_syn.ncbi_taxonomy_id / _pdbx_entity_src_syn.organism_scientificRevision 1.5 Nov 10, 2021 Group : Database references / Derived calculations / Category : database_2 / struct_conn / struct_ref_seq_difItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_label_asym_id / _struct_ref_seq_dif.details Revision 1.6 Oct 25, 2023 Group : Data collection / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model / struct_ncs_dom_lim Item : _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.end_auth_comp_id
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