登録情報 | データベース: PDB / ID: 2kbs |
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タイトル | Solution structure of harmonin PDZ2 in complex with the carboxyl tail peptide of cadherin23 |
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要素 | - Harmonin
- octameric peptide from Cadherin-23
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キーワード | STRUCTURAL PROTEIN/CELL ADHESION / PROTEIN COMPLEX / Alternative splicing / Coiled coil / Deafness / Hearing / Non-syndromic deafness / Polymorphism / Retinitis pigmentosa / Sensory transduction / Usher syndrome / Vision / Calcium / Cell adhesion / Cell membrane / Disease mutation / Glycoprotein / Membrane / Phosphoprotein / Transmembrane / STRUCTURAL PROTEIN-CELL ADHESION COMPLEX |
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機能・相同性 | 機能・相同性情報
protein localization to microvillus / brush border assembly / regulation of microvillus length / stereocilia ankle link complex / parallel actin filament bundle assembly / cochlear hair cell ribbon synapse / kinocilium / equilibrioception / sensory perception of light stimulus / retinal cone cell development ...protein localization to microvillus / brush border assembly / regulation of microvillus length / stereocilia ankle link complex / parallel actin filament bundle assembly / cochlear hair cell ribbon synapse / kinocilium / equilibrioception / sensory perception of light stimulus / retinal cone cell development / stereocilium tip / inner ear receptor cell stereocilium organization / inner ear auditory receptor cell differentiation / cell-cell adhesion via plasma-membrane adhesion molecules / photoreceptor ribbon synapse / stereocilium / calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules / photoreceptor cell maintenance / catenin complex / response to stimulus / auditory receptor cell stereocilium organization / Sensory processing of sound by outer hair cells of the cochlea / Sensory processing of sound by inner hair cells of the cochlea / inner ear morphogenesis / spectrin binding / cochlea development / homophilic cell adhesion via plasma membrane adhesion molecules / brush border / microvillus / actin filament bundle assembly / photoreceptor outer segment / regulation of cytosolic calcium ion concentration / visual perception / photoreceptor inner segment / locomotory behavior / sensory perception of sound / cilium / G2/M transition of mitotic cell cycle / calcium ion transport / apical part of cell / protein-containing complex assembly / cytoskeleton / cadherin binding / centrosome / synapse / calcium ion binding / membrane / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 Harmonin, N-terminal domain / Harmonin / Cadherin / Cadherin conserved site / Cadherin domain signature. / Cadherin repeats. / Cadherin domain / Cadherins domain profile. / Cadherin-like / Cadherin-like superfamily ...Harmonin, N-terminal domain / Harmonin / Cadherin / Cadherin conserved site / Cadherin domain signature. / Cadherin repeats. / Cadherin domain / Cadherins domain profile. / Cadherin-like / Cadherin-like superfamily / PDZ domain / Pdz3 Domain / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Roll / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / simulated annealing |
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Model details | lowest energy, model 20 |
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データ登録者 | Pan, L. / Yan, J. / Wu, L. / Zhang, M. |
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引用 | ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 2009 タイトル: Assembling stable hair cell tip link complex via multidentate interactions between harmonin and cadherin 23 著者: Pan, L. / Yan, J. / Wu, L. / Zhang, M. |
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履歴 | 登録 | 2008年12月5日 | 登録サイト: BMRB / 処理サイト: PDBJ |
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改定 1.0 | 2009年3月31日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2022年3月16日 | Group: Database references / Derived calculations カテゴリ: database_2 / pdbx_struct_assembly / pdbx_struct_oper_list Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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改定 1.3 | 2024年5月29日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond |
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