- PDB-2k1r: The solution NMR structure of the complex between MNK1 and HAH1 m... -
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Basic information
Entry
Database: PDB / ID: 2k1r
Title
The solution NMR structure of the complex between MNK1 and HAH1 mediated by Cu(I)
Components
Copper transport protein ATOX1
Copper-transporting ATPase 1
Keywords
HYDROLASE/CHAPERONE / MNK1 / HAH1 / protein-protein interaction / ATP7A / SPINE 2 / Structural Proteomics in Europe / Alternative splicing / ATP-binding / Copper / Copper transport / Cytoplasm / Disease mutation / Endoplasmic reticulum / Glycoprotein / Golgi apparatus / Hydrolase / Ion transport / Magnesium / Membrane / Metal-binding / Nucleotide-binding / Phosphoprotein / Polymorphism / Transmembrane / Transport / Chaperone / HYDROLASE-CHAPERONE COMPLEX / Structural Genomics
Function / homology
Function and homology information
peptidyl-lysine modification / epinephrine metabolic process / elastin biosynthetic process / positive regulation of response to wounding / metallochaperone activity / tryptophan metabolic process / cellular response to cobalt ion / Ion influx/efflux at host-pathogen interface / positive regulation of tyrosinase activity / copper-dependent protein binding ...peptidyl-lysine modification / epinephrine metabolic process / elastin biosynthetic process / positive regulation of response to wounding / metallochaperone activity / tryptophan metabolic process / cellular response to cobalt ion / Ion influx/efflux at host-pathogen interface / positive regulation of tyrosinase activity / copper-dependent protein binding / copper chaperone activity / cerebellar Purkinje cell differentiation / elastic fiber assembly / response to iron(III) ion / copper ion transmembrane transporter activity / P-type divalent copper transporter activity / P-type monovalent copper transporter activity / P-type Cu+ transporter / positive regulation of melanin biosynthetic process / superoxide dismutase copper chaperone activity / cellular response to lead ion / pyramidal neuron development / copper ion export / copper ion import / copper ion homeostasis / copper ion transport / melanosome membrane / catecholamine metabolic process / serotonin metabolic process / detoxification of copper ion / norepinephrine metabolic process / trans-Golgi network transport vesicle / regulation of oxidative phosphorylation / T-helper cell differentiation / positive regulation of vascular associated smooth muscle cell migration / collagen fibril organization / cartilage development / response to manganese ion / negative regulation of iron ion transmembrane transport / cellular response to antibiotic / skin development / hair follicle morphogenesis / pigmentation / dopamine metabolic process / lung alveolus development / response to zinc ion / cellular response to platelet-derived growth factor stimulus / positive regulation of catalytic activity / cell leading edge / blood vessel development / central nervous system neuron development / Detoxification of Reactive Oxygen Species / cuprous ion binding / Ion transport by P-type ATPases / microvillus / positive regulation of cell size / intracellular copper ion homeostasis / blood vessel remodeling / positive regulation of lamellipodium assembly / cellular response to copper ion / cellular response to cadmium ion / lactation / removal of superoxide radicals / mitochondrion organization / extracellular matrix organization / neuron projection morphogenesis / trans-Golgi network membrane / liver development / secretory granule / locomotory behavior / positive regulation of epithelial cell proliferation / female pregnancy / cellular response to iron ion / brush border membrane / cellular response to amino acid stimulus / trans-Golgi network / small GTPase binding / phagocytic vesicle membrane / late endosome / early endosome membrane / protein-folding chaperone binding / cellular response to hypoxia / basolateral plasma membrane / perikaryon / in utero embryonic development / response to oxidative stress / postsynaptic density / neuron projection / apical plasma membrane / copper ion binding / axon / neuronal cell body / dendrite / perinuclear region of cytoplasm / Golgi apparatus / endoplasmic reticulum / ATP hydrolysis activity / ATP binding / membrane / plasma membrane Similarity search - Function
NOE constraints total: 2206 / NOE intraresidue total count: 452 / NOE long range total count: 784 / NOE medium range total count: 413 / NOE sequential total count: 557 / Protein phi angle constraints total count: 91 / Protein psi angle constraints total count: 91
NMR representative
Selection criteria: closest to the average
NMR ensemble
Conformer selection criteria: structures with the least restraint violations Conformers calculated total number: 100 / Conformers submitted total number: 20
NMR ensemble rms
Distance rms dev: 0.0088 Å / Distance rms dev error: 0.001 Å
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