登録情報 データベース : PDB / ID : 2ijo 構造の表示 ダウンロードとリンクタイトル Crystal Structure of the West Nile virus NS2B-NS3 protease complexed with bovine pancreatic trypsin inhibitor 要素(Polyprotein) x 2 Pancreatic trypsin inhibitor 詳細キーワード HYDROLASE/HYDROLASE INHIBITOR / WEST NILE VIRUS / PROTEASE / APROTININ / BPTI / NS2B / NS3 / FLAVIVIRUS / serine protease / HYDROLASE-HYDROLASE INHIBITOR COMPLEX機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
RNA 5'-cap (guanine-N7)-methylation / RNA stabilization / DNA/DNA annealing activity / RNA folding chaperone / RNA strand annealing activity / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of JAK1 activity / trypsinogen activation / symbiont-mediated suppression of host apoptosis / negative regulation of serine-type endopeptidase activity / sulfate binding ... RNA 5'-cap (guanine-N7)-methylation / RNA stabilization / DNA/DNA annealing activity / RNA folding chaperone / RNA strand annealing activity / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of JAK1 activity / trypsinogen activation / symbiont-mediated suppression of host apoptosis / negative regulation of serine-type endopeptidase activity / sulfate binding / potassium channel inhibitor activity / negative regulation of platelet aggregation / zymogen binding / molecular function inhibitor activity / negative regulation of thrombin-activated receptor signaling pathway / flavivirin / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity / positive regulation of viral genome replication / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity / serine protease inhibitor complex / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity / ribonucleoside triphosphate phosphatase activity / serine-type endopeptidase inhibitor activity / protein-DNA complex / viral capsid / peptidase activity / double-stranded RNA binding / nucleoside-triphosphate phosphatase / protease binding / mRNA (guanine-N7)-methyltransferase / methyltransferase cap1 / clathrin-dependent endocytosis of virus by host cell / methyltransferase cap1 activity / mRNA 5'-cap (guanine-N7-)-methyltransferase activity / RNA helicase activity / protein dimerization activity / host cell perinuclear region of cytoplasm / host cell endoplasmic reticulum membrane / RNA helicase / symbiont-mediated suppression of host innate immune response / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / symbiont entry into host cell / ribonucleoprotein complex / symbiont-mediated activation of host autophagy / RNA-directed RNA polymerase / serine-type endopeptidase activity / viral RNA genome replication / RNA-directed RNA polymerase activity / fusion of virus membrane with host endosome membrane / viral envelope / calcium ion binding / virion attachment to host cell / host cell nucleus / virion membrane / structural molecule activity / ATP hydrolysis activity / proteolysis / DNA binding / extracellular space / RNA binding / extracellular region / ATP binding / metal ion binding / membrane 類似検索 - 分子機能 : / Pancreatic trypsin inhibitor Kunitz domain / Thrombin, subunit H - #120 / Factor Xa Inhibitor / Proteinase inhibitor I2, Kunitz, conserved site / Pancreatic trypsin inhibitor (Kunitz) family signature. / BPTI/Kunitz family of serine protease inhibitors. / Pancreatic trypsin inhibitor Kunitz domain / Kunitz/Bovine pancreatic trypsin inhibitor domain / Pancreatic trypsin inhibitor (Kunitz) family profile. ... : / Pancreatic trypsin inhibitor Kunitz domain / Thrombin, subunit H - #120 / Factor Xa Inhibitor / Proteinase inhibitor I2, Kunitz, conserved site / Pancreatic trypsin inhibitor (Kunitz) family signature. / BPTI/Kunitz family of serine protease inhibitors. / Pancreatic trypsin inhibitor Kunitz domain / Kunitz/Bovine pancreatic trypsin inhibitor domain / Pancreatic trypsin inhibitor (Kunitz) family profile. / Pancreatic trypsin inhibitor Kunitz domain superfamily / Flavivirus non-structural protein NS2B / Flavivirus capsid protein C superfamily / Genome polyprotein, Flavivirus / : / Flavivirus non-structural protein NS4A / Flavivirus non-structural protein NS2B / Flavivirus non-structural protein NS4B / mRNA cap 0/1 methyltransferase / Flavivirus non-structural protein NS4B / Flavivirus non-structural protein NS4A / Flavivirus NS2B domain profile. / mRNA cap 0 and cap 1 methyltransferase (EC 2.1.1.56 and EC 2.1.1.57) domain profile. / Flavivirus non-structural protein NS2A / Flavivirus non-structural protein NS2A / Flavivirus NS3, petidase S7 / Peptidase S7, Flavivirus NS3 serine protease / Flavivirus NS3 protease (NS3pro) domain profile. / RNA-directed RNA polymerase, thumb domain, Flavivirus / Flavivirus RNA-directed RNA polymerase, thumb domain / RNA-directed RNA polymerase, flavivirus / Flavivirus RNA-directed RNA polymerase, fingers and palm domains / Flavivirus capsid protein C / Flavivirus capsid protein C / Flavivirus non-structural Protein NS1 / Flavivirus non-structural protein NS1 / Envelope glycoprotein M, flavivirus / Envelope glycoprotein M superfamily, flavivirus / Flavivirus envelope glycoprotein M / Flavivirus polyprotein propeptide / Flavivirus polyprotein propeptide superfamily / Flavivirus polyprotein propeptide / Flavivirus envelope glycoprotein E, stem/anchor domain / : / Flavivirus NS3 helicase, C-terminal helical domain / Flavivirus envelope glycoprotein E, Stem/Anchor domain / Flavivirus envelope glycoprotein E, Stem/Anchor domain superfamily / Flavivirus glycoprotein E, immunoglobulin-like domain / Flavivirus glycoprotein, immunoglobulin-like domain / Flavivirus glycoprotein central and dimerisation domain / Flavivirus glycoprotein, central and dimerisation domains / Flaviviral glycoprotein E, central domain, subdomain 1 / Flaviviral glycoprotein E, central domain, subdomain 2 / Ribosomal RNA methyltransferase, FtsJ domain / FtsJ-like methyltransferase / Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily / Flavivirus glycoprotein, central and dimerisation domain superfamily / Flaviviral glycoprotein E, dimerisation domain / DEAD box, Flavivirus / Flavivirus DEAD domain / Few Secondary Structures / Irregular / helicase superfamily c-terminal domain / Immunoglobulin E-set / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / DEAD-like helicases superfamily / Helicase, C-terminal / Helicase superfamily 1/2, ATP-binding domain / Trypsin-like serine proteases / Thrombin, subunit H / RNA-directed RNA polymerase, catalytic domain / RdRp of positive ssRNA viruses catalytic domain profile. / S-adenosyl-L-methionine-dependent methyltransferase superfamily / Peptidase S1, PA clan / DNA/RNA polymerase superfamily / Beta Barrel / P-loop containing nucleoside triphosphate hydrolase / Mainly Beta 類似検索 - ドメイン・相同性 Pancreatic trypsin inhibitor / Genome polyprotein / Genome polyprotein 類似検索 - 構成要素生物種 West Nile virus (西ナイルウイルス)Bos taurus (ウシ)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.3 Å 詳細データ登録者 Aleshin, A.E. / Shiryaev, S.A. / Strongin, A.Y. / Liddington, R.C. 引用ジャーナル : Protein Sci. / 年 : 2007タイトル : Structural evidence for regulation and specificity of flaviviral proteases and evolution of the Flaviviridae fold.著者 : Aleshin, A.E. / Shiryaev, S.A. / Strongin, A.Y. / Liddington, R.C. 履歴 登録 2006年9月29日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2007年5月15日 Provider : repository / タイプ : Initial release改定 1.1 2008年5月1日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Version format compliance改定 1.3 2021年10月20日 Group : Database references / カテゴリ : database_2 / struct_ref_seq_difItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details改定 1.4 2023年8月30日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model改定 1.5 2024年10月30日 Group : Structure summaryカテゴリ : pdbx_entry_details / pdbx_modification_feature
すべて表示 表示を減らす Remark 400 COMPOUND THE PROTEINS NS2B (CHAIN A) AND NS3 (CHAIN B) ARE CONNECTED THROUGH A LINKER AGGGGSGGGG. Remark 999 SEQUENCE THIS IS THE SEQUENCE OF THE LINKER BETWEEN CHAINS A AND B. RESIDUE NUMBERS 1 THROUGH 5 IN ... SEQUENCE THIS IS THE SEQUENCE OF THE LINKER BETWEEN CHAINS A AND B. RESIDUE NUMBERS 1 THROUGH 5 IN COORDINATES FOR CHAIN B ARE ARBITRARY, SINCE ONLY THESE FIVE RESIDUES WERE VISIBLE IN ELECTRON DENSITY. THE SEQUENCE ALIGNMENT OF THESE FIVE RESIDUES IS ALSO ARBITRARY AND IS BASED ONLY ON THE DISTANCE CRITERIA TO THE NEXT VISIBLE RESIDUES.