[English] 日本語
![](img/lk-miru.gif)
- PDB-2ig2: DIR PRIMAERSTRUKTUR DES KRISTALLISIERBAREN MONOKLONALEN IMMUNOGLO... -
+
Open data
-
Basic information
Entry | Database: PDB / ID: 2ig2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Title | DIR PRIMAERSTRUKTUR DES KRISTALLISIERBAREN MONOKLONALEN IMMUNOGLOBULINS IGG1 KOL. II. AMINOSAEURESEQUENZ DER L-KETTE, LAMBDA-TYP, SUBGRUPPE I (GERMAN) | |||||||||
![]() |
| |||||||||
![]() | IMMUNOGLOBULIN | |||||||||
Function / homology | ![]() IgD immunoglobulin complex / IgM immunoglobulin complex / IgA immunoglobulin complex / IgE immunoglobulin complex / CD22 mediated BCR regulation / immunoglobulin complex / IgG immunoglobulin complex / Fc epsilon receptor (FCERI) signaling / Classical antibody-mediated complement activation / Initial triggering of complement ...IgD immunoglobulin complex / IgM immunoglobulin complex / IgA immunoglobulin complex / IgE immunoglobulin complex / CD22 mediated BCR regulation / immunoglobulin complex / IgG immunoglobulin complex / Fc epsilon receptor (FCERI) signaling / Classical antibody-mediated complement activation / Initial triggering of complement / FCGR activation / immunoglobulin mediated immune response / Role of phospholipids in phagocytosis / Role of LAT2/NTAL/LAB on calcium mobilization / Scavenging of heme from plasma / FCERI mediated Ca+2 mobilization / FCGR3A-mediated IL10 synthesis / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / Regulation of Complement cascade / antigen binding / Cell surface interactions at the vascular wall / FCERI mediated MAPK activation / FCGR3A-mediated phagocytosis / B cell receptor signaling pathway / Regulation of actin dynamics for phagocytic cup formation / FCERI mediated NF-kB activation / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / adaptive immune response / Potential therapeutics for SARS / blood microparticle / immune response / extracellular space / extracellular exosome / extracellular region / plasma membrane Similarity search - Function | |||||||||
Biological species | ![]() | |||||||||
Method | ![]() | |||||||||
![]() | Marquart, M. / Huber, R. | |||||||||
![]() | ![]() Title: The primary structure of crystallizable monoclonal immunoglobulin IgG1 Kol. II. Amino acid sequence of the L-chain, gamma-type, subgroup I Authors: Kratzin, H.D. / Palm, W. / Stangel, M. / Schmidt, W.E. / Friedrich, J. / Hilschmann, N. #1: ![]() Title: The Three-Dimensional Structure of Antibodies Authors: Marquart, M. / Deisenhofer, J. #2: ![]() Title: Crystallographic Refinement and Atomic Models of the Intact Immunoglobulin Molecule Kol and its Antigen-Binding Fragment at 3.0 Angstroms and 1.9 Angstroms Resolution Authors: Marquart, M. / Deisenhofer, J. / Huber, R. / Palm, W. #3: ![]() Title: Crystal Structure of the Human Fab Fragment Kol and its Comparison with the Intact Kol Molecule Authors: Matsushima, M. / Marquart, M. / Jones, T.A. / Colman, P.M. / Bartels, K. / Huber, R. #4: ![]() Title: Crystallographic Structure Studies of an Igg Molecule and an Fc Fragment Authors: Huber, R. / Deisenhofer, J. / Colman, P.M. / Matsushima, M. / Palm, W. #5: ![]() Title: Structure of the Human Antibody Molecule Kol (Immunoglobulin G1). An Electron Density Map at 5 Angstroms Resolution Authors: Colman, P.M. / Deisenhofer, J. / Huber, R. / Palm, W. | |||||||||
History |
|
-
Structure visualization
Structure viewer | Molecule: ![]() ![]() |
---|
-
Downloads & links
-
Download
PDBx/mmCIF format | ![]() | 89.3 KB | Display | ![]() |
---|---|---|---|---|
PDB format | ![]() | 69.7 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
---|
-Related structure data
-
Links
-
Assembly
Deposited unit | ![]()
| ||||||||
---|---|---|---|---|---|---|---|---|---|
1 |
| ||||||||
Unit cell |
| ||||||||
Atom site foot note | 1: RESIDUES L 143, H 152, H 154 ARE CIS-PROLINES. 2: THESE ATOMS WERE NOT FOUND IN THE ELECTRON DENSITY MAP. THEIR COORDINATES WERE GENERATED USING STEREOCHEMICAL CRITERIA. 3: SEE REMARK 7. | ||||||||
Details | THE FOLLOWING CRYSTALLOGRAPHIC TRANSFORMATION WILL GENERATE COORDINATES FOR THE OTHER HALF OF THE MOLECULE WHEN APPLIED TO THE COORDINATES IN THIS ENTRY 1.0 0.0 0.0 0.0 0.0 -1.0 0.0 234.866 0.0 0.0 -1.0 191.56 |
-
Components
#1: Antibody | Mass: 22817.348 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() |
---|---|
#2: Antibody | Mass: 49787.875 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() |
-Experimental details
-Experiment
Experiment | Method: ![]() |
---|
-
Sample preparation
Crystal | Density Matthews: 3 Å3/Da / Density % sol: 58.98 % |
---|---|
Crystal grow | *PLUS Method: unknown |
-
Processing
Software | Name: EREF / Classification: refinement | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Refinement | Resolution: 3→6 Å / Rfactor Rwork: 0.207 | ||||||||||||
Refinement step | Cycle: LAST / Resolution: 3→6 Å
| ||||||||||||
Refinement | *PLUS Rfactor Rwork: 0.207 | ||||||||||||
Solvent computation | *PLUS | ||||||||||||
Displacement parameters | *PLUS |