登録情報 | データベース: PDB / ID: 2hel |
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タイトル | Crystal structure of a mutant EphA4 kinase domain (Y742A) |
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要素 | Eph receptor A4 |
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キーワード | SIGNALING PROTEIN / TRANSFERASE / Tyr kinase / activation |
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機能・相同性 | 機能・相同性情報
DH domain binding / EPH-Ephrin signaling / neuron projection fasciculation / positive regulation of Rho guanyl-nucleotide exchange factor activity / EPHA-mediated growth cone collapse / corticospinal tract morphogenesis / regulation of astrocyte differentiation / negative regulation of proteolysis involved in protein catabolic process / : / EPH-ephrin mediated repulsion of cells ...DH domain binding / EPH-Ephrin signaling / neuron projection fasciculation / positive regulation of Rho guanyl-nucleotide exchange factor activity / EPHA-mediated growth cone collapse / corticospinal tract morphogenesis / regulation of astrocyte differentiation / negative regulation of proteolysis involved in protein catabolic process / : / EPH-ephrin mediated repulsion of cells / neuron projection guidance / nephric duct morphogenesis / fasciculation of sensory neuron axon / fasciculation of motor neuron axon / regulation of synapse pruning / synapse pruning / positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process / negative regulation of cellular response to hypoxia / negative regulation of axon regeneration / glial cell migration / PH domain binding / multicellular organism development / GPI-linked ephrin receptor activity / regulation of modification of synaptic structure / regulation of dendritic spine morphogenesis / transmembrane-ephrin receptor activity / negative regulation of cell adhesion / negative regulation of epithelial to mesenchymal transition / positive regulation of kinase activity / adult walking behavior / motor neuron axon guidance / adherens junction organization / positive regulation of dendrite morphogenesis / positive regulation of amyloid-beta formation / regulation of axonogenesis / cochlea development / regulation of GTPase activity / plasma membrane => GO:0005886 / positive regulation of protein tyrosine kinase activity / positive regulation of cell adhesion / negative regulation of long-term synaptic potentiation / ephrin receptor signaling pathway / axonal growth cone / axon terminus / positive regulation of JUN kinase activity / cell surface receptor protein tyrosine kinase signaling pathway / ephrin receptor binding / transmembrane receptor protein tyrosine kinase activity / negative regulation of cell migration / protein tyrosine kinase binding / dendritic shaft / filopodium / cell projection / adherens junction / postsynaptic density membrane / axon guidance / Schaffer collateral - CA1 synapse / neuromuscular junction / receptor protein-tyrosine kinase / negative regulation of ERK1 and ERK2 cascade / peptidyl-tyrosine phosphorylation / cellular response to amyloid-beta / negative regulation of neuron projection development / presynaptic membrane / kinase activity / early endosome membrane / cell body / postsynaptic membrane / perikaryon / mitochondrial outer membrane / protein autophosphorylation / dendritic spine / postsynaptic density / receptor complex / protein stabilization / cell adhesion / protein kinase activity / positive regulation of cell migration / neuron projection / axon / glutamatergic synapse / dendrite / positive regulation of cell population proliferation / Golgi apparatus / cell surface / endoplasmic reticulum / ATP binding / identical protein binding / plasma membrane / cytoplasm類似検索 - 分子機能 Ephrin type-A receptor 4, SAM domain / Ephrin type-A receptor 4, ligand binding domain / Tyrosine-protein kinase ephrin type A/B receptor-like / Tyrosine-protein kinase ephrin type A/B receptor-like / Ephrin receptor type-A /type-B / Ephrin receptor ligand binding domain / Tyrosine-protein kinase, receptor class V, conserved site / Ephrin receptor, transmembrane domain / Ephrin receptor ligand binding domain / Ephrin type-A receptor 2 transmembrane domain ...Ephrin type-A receptor 4, SAM domain / Ephrin type-A receptor 4, ligand binding domain / Tyrosine-protein kinase ephrin type A/B receptor-like / Tyrosine-protein kinase ephrin type A/B receptor-like / Ephrin receptor type-A /type-B / Ephrin receptor ligand binding domain / Tyrosine-protein kinase, receptor class V, conserved site / Ephrin receptor, transmembrane domain / Ephrin receptor ligand binding domain / Ephrin type-A receptor 2 transmembrane domain / Receptor tyrosine kinase class V signature 1. / Receptor tyrosine kinase class V signature 2. / Eph receptor ligand-binding domain profile. / Ephrin receptor ligand binding domain / Putative ephrin-receptor like / SAM domain (Sterile alpha motif) / SAM domain profile. / Sterile alpha motif. / Sterile alpha motif domain / Sterile alpha motif/pointed domain superfamily / Fibronectin type III domain / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Galactose-binding-like domain superfamily / Fibronectin type III / Fibronectin type III superfamily / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Ephrin type-A receptor 4 / Ephrin type-A receptor 4類似検索 - 構成要素 |
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生物種 | ![](img/tx_mammal.gif) Mus musculus (ハツカネズミ) |
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手法 | X線回折 / 分子置換 / 解像度: 2.35 Å |
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データ登録者 | Wybenga-Groot, L.E. / Sicheri, F. / Pawson, T. |
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引用 | ジャーナル: EMBO J. / 年: 2006 タイトル: A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases. 著者: Wiesner, S. / Wybenga-Groot, L.E. / Warner, N. / Lin, H. / Pawson, T. / Forman-Kay, J.D. / Sicheri, F. |
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履歴 | 登録 | 2006年6月21日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2007年2月13日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年5月1日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2021年10月20日 | Group: Database references / カテゴリ: database_2 / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details |
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改定 1.4 | 2024年2月14日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond |
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