coagulation factor Xa / Defective factor IX causes thrombophilia / Defective cofactor function of FVIIIa variant / Defective F9 variant does not activate FX / Extrinsic Pathway of Fibrin Clot Formation / positive regulation of leukocyte chemotaxis / positive regulation of TOR signaling / Gamma-carboxylation of protein precursors / Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus / Common Pathway of Fibrin Clot Formation ...coagulation factor Xa / Defective factor IX causes thrombophilia / Defective cofactor function of FVIIIa variant / Defective F9 variant does not activate FX / Extrinsic Pathway of Fibrin Clot Formation / positive regulation of leukocyte chemotaxis / positive regulation of TOR signaling / Gamma-carboxylation of protein precursors / Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus / Common Pathway of Fibrin Clot Formation / Removal of aminoterminal propeptides from gamma-carboxylated proteins / Intrinsic Pathway of Fibrin Clot Formation / serine-type endopeptidase inhibitor activity / phospholipid binding / Golgi lumen / blood coagulation / positive regulation of cell migration / endoplasmic reticulum lumen / external side of plasma membrane / serine-type endopeptidase activity / calcium ion binding / proteolysis / extracellular space / extracellular region / plasma membrane 類似検索 - 分子機能
ジャーナル: J.Mol.Biol. / 年: 2007 タイトル: Intermolecular Interactions and Characterization of the Novel Factor Xa Exosite Involved in Macromolecular Recognition and Inhibition: Crystal Structure of Human Gla-domainless Factor ...タイトル: Intermolecular Interactions and Characterization of the Novel Factor Xa Exosite Involved in Macromolecular Recognition and Inhibition: Crystal Structure of Human Gla-domainless Factor Xa Complexed with the Anticoagulant Protein NAPc2 from the Hematophagous Nematode Ancylostoma caninum. 著者: Murakami, M.T. / Rios-Steiner, J. / Weaver, S.E. / Tulinsky, A. / Geiger, J.H. / Arni, R.K.
履歴
登録
2006年6月9日
登録サイト: RCSB / 処理サイト: RCSB
改定 1.0
2007年2月13日
Provider: repository / タイプ: Initial release
改定 1.1
2008年5月1日
Group: Version format compliance
改定 1.2
2011年7月13日
Group: Atomic model / Database references ...Atomic model / Database references / Derived calculations / Non-polymer description / Structure summary / Version format compliance
The biological assembly is the chain H (catalytic domain or heavy chain) and chain L (EGF2 domain or light chain), which forms the Gla-domainless factor Xa
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要素
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Coagulation factor X ... , 2種, 2分子 HL
#1: タンパク質
CoagulationfactorXheavychain
分子量: 26346.000 Da / 分子数: 1 / 断片: catalytic domain / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P00742, coagulation factor Xa
#2: タンパク質
CoagulationfactorXlightchain
分子量: 16366.871 Da / 分子数: 1 / 断片: EGF-like 1 domain / 由来タイプ: 天然 / 由来: (天然) Homo sapiens (ヒト) / 参照: UniProt: P00742, coagulation factor Xa