PDB-2gcg: Ternary Crystal Structure of Human Glyoxylate Reductase/Hydroxypy...

ID or keywords:

Entry

Database: PDB / ID: 2gcg

Title

Ternary Crystal Structure of Human Glyoxylate Reductase/Hydroxypyruvate Reductase

Components

Glyoxylate reductase/hydroxypyruvate reductase

Keywords

OXIDOREDUCTASE / NAD(P) Rossmann Fold / Formate/Glycerate Dehydrogenase Substrate-Binding Domain

Function / homology

Function and homology information

dicarboxylic acid metabolic process / hydroxypyruvate reductase (NADPH) activity / hydroxypyruvate reductase / glyoxylate reductase (NADP+) / hydroxypyruvate reductase (NADH) activity / glyoxylate metabolic process / hydroxypyruvate reductase [NAD(P)H] activity / glyoxylate reductase (NADPH) activity / Glyoxylate metabolism and glycine degradation / carboxylic acid binding ...
Similarity search - Function

Biological species

Homo sapiens (human)

Method

X-RAY DIFFRACTION /

SYNCHROTRON /

MOLECULAR REPLACEMENT / Resolution: 2.2 Å

Authors

Booth, M.P.S. / Conners, R. / Rumsby, G. / Brady, R.L.

Citation

Journal: J.Mol.Biol. / Year: 2006
Title: Structural basis of substrate specificity in human glyoxylate reductase/hydroxypyruvate reductase
Authors: Booth, M.P.S. / Conners, R. / Rumsby, G. / Brady, R.L.

History

Deposition	Mar 14, 2006	Deposition site: RCSB / Processing site: PDBJ
Revision 1.0	Jul 18, 2006	Provider: repository / Type: Initial release
Revision 1.1	May 1, 2008	Group: Version format compliance
Revision 1.2	Jul 13, 2011	Group: Advisory / Version format compliance
Revision 1.3	Oct 18, 2017	Group: Refinement description / Category: software Item: _software.classification / _software.contact_author ..._software.classification / _software.contact_author / _software.contact_author_email / _software.date / _software.language / _software.location / _software.name / _software.type / _software.version
Revision 1.4	Oct 25, 2023	Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id

Structure viewer	Molecule: MolmilJmol/JSmol

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PDBx/mmCIF format	2gcg.cif.gz	275.4 KB	Display	PDBx/mmCIF format
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Validation report

Summary document	2gcg_validation.pdf.gz	1.5 MB	Display	wwPDB validaton report
Full document	2gcg_full_validation.pdf.gz	1.5 MB	Display
Data in XML	2gcg_validation.xml.gz	59.6 KB	Display
Data in CIF	2gcg_validation.cif.gz	81.6 KB	Display
Arichive directory	https://data.pdbj.org/pub/pdb/validation_reports/gc/2gcg ftp://data.pdbj.org/pub/pdb/validation_reports/gc/2gcg	HTTPS FTP

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Related structure data

Related structure data	2wwrC 1gdhS S: Starting model for refinement C: citing same article (ref.)
Similar structure data	2h1s-2 4e5n-4 2q50-2 4nu6-d 3baz-1 4ebf-1 4nu5-d 6v8a-1 4e5p-3 4ebf-3 Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Similarity search - Function & homologyF&H Search Similarity search - FunctionF&H Search Similarity search - HomologyF&H Search

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Links

PDB pages	PDBj / wwPDB / NCBI
Related items in Molecule of the Month	#34 - Oct 2002 Dihydrofolate Reductase similarity (1) #57 - Sep 2004 Catalase similarity (1)

Deposited unit

A: Glyoxylate reductase/hydroxypyruvate reductase

B: Glyoxylate reductase/hydroxypyruvate reductase

C: Glyoxylate reductase/hydroxypyruvate reductase

D: Glyoxylate reductase/hydroxypyruvate reductase

hetero molecules

147 kDa, 4 polymers
Search similar-shape structures of this assembly by Omokage search (details)

1

A: Glyoxylate reductase/hydroxypyruvate reductase

B: Glyoxylate reductase/hydroxypyruvate reductase

hetero molecules

defined by author&software
73.4 kDa, 2 polymers
Search similar-shape structures of this assembly by Omokage search (details)

2

C: Glyoxylate reductase/hydroxypyruvate reductase

D: Glyoxylate reductase/hydroxypyruvate reductase

hetero molecules

defined by author&software
73.7 kDa, 2 polymers
Search similar-shape structures of this assembly by Omokage search (details)

Unit cell

Length a, b, c (Å)	76.568, 66.877, 149.780
Angle α, β, γ (deg.)	90.00, 98.22, 90.00
Int Tables number	4
Space group name H-M	P12₁1

Details

Biological unit is a dimer, 2 dimers are present in the asymmetric unit (A,B and C,D).

#1: Protein	Glyoxylate reductase/hydroxypyruvate reductase Mass: 35869.363 Da / Num. of mol.: 4 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Plasmid: pTrcHisB / Production host: Escherichia coli (E. coli) / References: UniProt: Q9UBQ7, glyoxylate reductase (NADP+)
#2: Chemical	ChemComp-NDP / NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Mass: 745.421 Da / Num. of mol.: 4 / Source method: obtained synthetically / Formula: C₂₁H₃₀N₇O₁₇P₃
#3: Chemical	ChemComp-DGY / (2R)-2,3-DIHYDROXYPROPANOIC ACID Mass: 106.077 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: C₃H₆O₄
#4: Chemical	ChemComp-SO4 / SULFATE ION Mass: 96.063 Da / Num. of mol.: 5 / Source method: obtained synthetically / Formula: SO₄
#5: Water	ChemComp-HOH / water Mass: 18.015 Da / Num. of mol.: 611 / Source method: isolated from a natural source / Formula: H₂O

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Experiment

Experiment	Method: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

Crystal	Density Matthews: 2.7 Å³/Da / Density % sol: 53.4 %
Crystal grow	Temperature: 291 K / Method: vapor diffusion, sitting drop / pH: 6.5 Details: 15% PEG 8000, 0.2M ammonium sulfate, 0.1M sodium cacodylate, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K

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Data collection

Diffraction	Mean temperature: 100 K
Diffraction source	Source: SYNCHROTRON / Site: SRS / Beamline: PX14.1 / Wavelength: 1.488 Å
Detector	Type: ADSC QUANTUM 4 / Detector: CCD / Date: Sep 29, 2005
Radiation	Monochromator: Si(111) / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelength	Wavelength: 1.488 Å / Relative weight: 1
Reflection	Resolution: 2.2→50 Å / Num. obs: 69070 / % possible obs: 90.3 % / Redundancy: 2.6 % / R_merge(I) obs: 0.121 / Χ²: 1.059 / Net I/σ(I): 7.5
Reflection shell	Resolution: 2.2→2.28 Å / % possible obs: 72.3 % / Redundancy: 2.2 % / R_merge(I) obs: 0.275 / Num. unique obs: 5483 / Χ²: 0.577 / % possible all: 72.3

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Processing

Software

Name	Version	Classification
DENZO		data reduction
SCALEPACK		data scaling
REFMAC	5.2.0005	refinement
PDB_EXTRACT	1.701	data extraction
HKL-2000		data reduction
PHASER	V. 1.3	phasing

Refinement

Method to determine structure:

MOLECULAR REPLACEMENT
Starting model: 1GDH

1gdh

Resolution: 2.2→46.2 Å / Cor.coef. F_o:F_c: 0.933 / Cor.coef. F_o:F_c free: 0.866 / SU B: 13.529 / SU ML: 0.189 / TLS residual ADP flag: LIKELY RESIDUAL / Cross valid method: THROUGHOUT / σ(F): 0 / ESU R: 0.319 / ESU R Free: 0.264 / Stereochemistry target values: MAXIMUM LIKELIHOOD

	R_factor	Num. reflection	% reflection	Selection details
R_free	0.282	3460	5 %	RANDOM
R_work	0.201	-	-	-
all	0.205	-	-	-
obs	0.205	69056	90.02 %	-

Solvent computation

Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å / Solvent model: BABINET MODEL WITH MASK

Displacement parameters

B_iso mean: 33.362 Å²

	B_aniso -1	B_aniso -2	B_aniso -3
1-	-0.09 Å²	0 Å²	-1.68 Å²
2-	-	-1.72 Å²	0 Å²
3-	-	-	1.32 Å²

Refinement step

Cycle: LAST / Resolution: 2.2→46.2 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	9859	0	231	611	10701

Refine LS restraints

Refine-ID	Type	Dev ideal	Dev ideal target	Number
X-RAY DIFFRACTION	r_bond_refined_d	0.017	0.022	10275
X-RAY DIFFRACTION	r_angle_refined_deg	1.857	2.008	13994
X-RAY DIFFRACTION	r_dihedral_angle_1_deg	6.888	5	1290
X-RAY DIFFRACTION	r_dihedral_angle_2_deg	36.513	23.632	402
X-RAY DIFFRACTION	r_dihedral_angle_3_deg	19.406	15	1730
X-RAY DIFFRACTION	r_dihedral_angle_4_deg	20.106	15	82
X-RAY DIFFRACTION	r_chiral_restr	0.127	0.2	1640
X-RAY DIFFRACTION	r_gen_planes_refined	0.006	0.02	7550
X-RAY DIFFRACTION	r_nbd_refined	0.225	0.2	4977
X-RAY DIFFRACTION	r_nbtor_refined	0.305	0.2	6815
X-RAY DIFFRACTION	r_xyhbond_nbd_refined	0.178	0.2	618
X-RAY DIFFRACTION	r_symmetry_vdw_refined	0.174	0.2	51
X-RAY DIFFRACTION	r_symmetry_hbond_refined	0.184	0.2	21
X-RAY DIFFRACTION	r_mcbond_it	0.706	1.5	6671
X-RAY DIFFRACTION	r_mcangle_it	1.128	2	10370
X-RAY DIFFRACTION	r_scbond_it	2.035	3	4088
X-RAY DIFFRACTION	r_scangle_it	2.932	4.5	3624

LS refinement shell

Resolution: 2.198→2.255 Å / Total num. of bins used: 20

	R_factor	Num. reflection	% reflection
R_free	0.309	203	-
R_work	0.212	3530	-
obs	-	3733	65.65 %

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°²)	L12 (°²)	L13 (°²)	L22 (°²)	L23 (°²)	L33 (°²)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å²)	T12 (Å²)	T13 (Å²)	T22 (Å²)	T23 (Å²)	T33 (Å²)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	5.162	0.1027	-2.4872	4.1656	0.2155	4.4444	0.1429	-0.9543	0.297	0.5247	-0.1851	0.3123	-0.0445	0.3371	0.0422	0.0189	0.0192	0.0352	0.1709	-0.0089	0.0736	17.3811	8.4781	13.6789
2	5.7005	-0.5704	-1.7893	4.2297	-0.0237	1.9443	-0.1308	-0.4884	-0.4527	0.1576	0.0634	-0.0748	-0.0249	0.4195	0.0674	-0.027	0.0318	0.0343	0.1068	0.0523	-0.0246	24.0497	1.1544	8.3951
3	0.7853	0.4419	-0.2911	3.8385	-1.3572	1.3114	-0.0137	-0.0033	-0.1416	-0.0276	0.0156	0.2054	0.0703	-0.077	-0.0019	-0.0508	-0.0044	-0.0218	0.0344	-0.0142	0.104	14.163	7.3018	-3.3926
4	2.661	-0.0743	-0.8745	0.6877	0.521	1.0086	0.1434	0.1261	-0.2532	-0.1782	0.0498	-0.0426	0.0483	0.044	-0.1932	0.0617	0.0082	0.0127	0.0878	-0.0157	0.0272	33.7601	32.1185	-26.0884
5	1.396	-0.0748	-0.7098	2.0109	-0.41	0.4609	0.0239	0.0734	-0.0142	-0.1343	-0.035	0.4512	-0.1605	-0.0349	0.0111	0.0253	-0.0584	-0.0407	0.1023	-0.0053	0.1309	7.8965	22.5622	-18.9114
6	0.0952	0.1216	-0.7664	12.3641	-3.8684	6.8509	-0.0101	0.1155	0.2597	-0.7867	0.1864	0.7843	0.3422	-0.6211	-0.1763	0.0075	-0.0371	-0.0467	0.2478	0.0277	0.1157	6.0569	23.2982	-21.9518
7	1.8585	-3.4615	-2.2298	9.097	0.4136	7.9522	-0.2781	0.0276	0.2674	-0.447	0.2352	0.5592	0.6285	-0.7344	0.0429	0.0602	-0.1497	-0.1426	0.242	0.0167	0.2142	0.7144	18.7867	-23.102
8	3.3357	0.6565	1.1599	2.3138	-1.6374	1.9966	-0.2379	0.2747	-0.4341	-0.3174	0.1726	0.031	0.5206	-0.348	0.0653	0.1191	-0.077	0.0151	0.0317	-0.072	0.0514	13.8303	11.7277	-26.5051
9	4.2407	-0.4063	0.9988	2.4062	-0.6944	1.9839	-0.179	0.1676	-0.2382	-0.3208	0.0348	-0.1708	0.345	0.146	0.1442	0.1277	0.0062	0.0465	-0.0276	-0.0105	0.017	24.9328	11.3247	-21.9943
10	1.1704	0.1123	-0.3981	0.6814	-0.2723	0.5938	-0.0681	-0.1473	0.0291	-0.0105	0.0103	0.2441	-0.0415	-0.0572	0.0577	0.0102	0.0289	0.0531	0.094	0.0004	0.1093	11.5839	13.0889	3.1864
11	4.1386	-0.4705	2.0774	2.7053	-0.9297	1.9732	0.2254	0.506	0.0804	-0.1221	-0.2183	0.1447	-0.0137	0.2277	-0.0071	0.0388	0.0669	0.058	0.2102	0.0218	-0.0121	31.2885	46.1664	-45.616
12	2.7376	-1.9884	1.4378	3.3427	-2.0884	3.8547	0.0586	0.2187	0.34	0.0261	0.0758	-0.1607	0.0314	-0.1404	-0.1344	-0.0191	0.038	0.0937	0.0751	-0.004	0.0294	40.2068	48.1978	-37.5433
13	4.3737	6.6853	0.1159	14.8526	-2.2925	1.3194	-0.2126	-0.0544	0.189	0.6448	-0.0935	-0.0644	-0.0788	0.2225	0.3062	0.0892	0.0078	0.0772	0.1694	-0.0154	0.0943	41.5992	59.2789	-33.7455
14	1.9343	0.8693	-1.4042	3.0592	-1.7373	2.5959	0.1693	0.0734	0.2024	0.0397	0.0241	0.0565	-0.2562	-0.0755	-0.1934	0.0438	0.0075	0.0421	0.0217	-0.0066	0.0088	26.8299	48.244	-26.6862
15	0.8772	-1.1562	-0.1995	1.5389	0.147	0.9392	-0.0121	-0.1531	0.0816	-0.198	-0.1821	-0.101	-0.0788	0.2046	0.1942	0.0445	-0.0022	-0.0025	0.1247	0.0415	0.0747	29.2078	17.0201	-6.6544
16	1.1102	-0.7264	-0.0599	1.7238	0.3844	0.3184	-0.0231	-0.0467	0.1812	0.1205	-0.0838	0.0215	-0.0968	-0.0104	0.1068	0.0343	-0.0123	0.0143	0.0686	-0.0075	0.1122	15.1712	41.8819	-10.3665
17	6.9609	-1.4074	1.171	5.978	1.3391	4.4511	0.1259	-0.1846	0.2147	0.2458	-0.2579	-0.1028	-0.2036	-0.29	0.132	-0.0266	0.0092	0.0762	0.0469	-0.0287	0.0914	12.289	49.939	-8.9512
18	2.8508	-0.4245	-1.1768	3.8106	2.349	1.7468	0.1934	-0.2192	0.2653	-0.0355	0.264	-0.122	-0.3881	-0.1832	-0.4574	0.081	-0.0103	0.0278	0.0726	-0.028	0.1301	23.8819	46.2246	-7.5704
19	2.509	-0.7807	-0.9022	1.3818	0.3535	2.1141	0.1035	-0.2567	0.1704	-0.0159	0.0723	-0.0329	0.031	0.1929	-0.1758	0.0082	-0.0313	0.0095	0.0867	-0.0517	0.0293	34.5978	40.2439	-8.1376
20	1.5937	-0.9095	0.9483	1.3322	-1.1524	1.1237	0.1259	0.1724	0.1628	-0.2581	-0.0779	-0.0183	0.1543	-0.0277	-0.048	0.0545	0.0434	0.0277	0.1133	0.0348	0.053	23.7999	46.69	-35.3319
21	3.5698	3.5308	0.3137	3.6001	-0.3862	4.5233	0.3346	0.4775	-0.4854	0.1628	0.148	0.0704	0.2431	-0.8245	-0.4826	0.0864	0.0166	0.0184	0.1455	-0.0648	0.0618	-41.4013	22.161	-55.3463
22	5.6682	-0.6531	-5.0175	1.3849	-0.7779	5.8455	0.0242	0.5409	-0.4261	0.0596	0.1182	0.0438	0.1112	-0.5069	-0.1424	0.1707	-0.0052	0.0485	0.1912	0.0035	0.1105	-46.1854	17.3065	-53.4585
23	5.7572	0.0048	-2.0378	0.2954	-0.4961	5.726	0.0515	0.3187	0.4864	-0.1606	0.0884	0.4562	-0.0775	0.0784	-0.1399	0.1362	0.0287	-0.009	0.0317	0.0269	-0.0131	-34.4635	26.8433	-62.4485
24	1.5966	-2.7903	-0.0769	4.8981	0.3264	1.7126	-0.005	0.0992	-0.0396	0.1103	0.0644	-0.1396	-0.3796	0.0421	-0.0594	0.1246	0.0034	0.0161	0.0478	-0.0053	0.002	-34.1479	30.2667	-51.4586
25	0.6376	-0.6384	-0.5137	1.2514	0.5353	0.8569	-0.0503	-0.1	-0.005	0.1641	0.0548	-0.1117	-0.0422	0.1148	-0.0045	0.0307	-0.0205	-0.0071	0.0952	-0.0073	0.0213	-15.0684	8.5721	-53.7697
26	2.0401	-2.5145	-2.9143	3.5259	3.229	4.4717	-0.2235	-0.3766	-0.8303	0.5244	-0.3164	0.6686	0.0452	0.1493	0.5399	0.1018	-0.0078	0.0119	0.1298	-0.0315	0.0887	-16.3383	5.0528	-41.8902
27	4.5627	-0.0813	0.3072	3.7153	1.7775	1.9727	-0.2247	-0.875	0.3013	0.3459	0.1301	-0.261	-0.0582	0.4056	0.0946	0.1309	-0.0712	-0.079	0.3297	-0.0529	-0.1181	-7.8657	7.2751	-36.5449
28	1.5235	-0.1325	-1.5169	1.2155	1.1359	2.9258	0.2064	-0.3072	0.3695	0.0473	0.0572	-0.0849	-0.3136	0.3104	-0.2636	0.0374	-0.0804	-0.0367	0.1039	-0.0442	0.0686	-4.9642	15.3149	-48.3484
29	1.9188	-0.4574	-0.4236	0.719	0.4169	1.5143	0.0141	-0.0946	0.1778	0.0666	0.0568	-0.0658	-0.1939	0.0786	-0.0709	0.0724	-0.0109	0.0229	-0.0076	0.0203	0.0284	-17.7767	15.1449	-55.984
30	10.0877	-8.2744	-2.3547	16.0588	2.299	1.5992	-0.8434	-1.6545	2.4731	0.8312	0.6251	-1.4929	-0.0314	0.3321	0.2183	0.0971	0.0128	-0.0004	0.0969	0.0109	0.0795	-33.2224	18.9851	-38.5798
31	13.3977	-7.9209	3.2544	5.7223	-0.017	13.8407	0.947	0.5875	-0.4248	-0.093	-0.5728	0.0543	0.8006	0.781	-0.3742	0.0373	0.118	-0.1016	0.0487	-0.0075	0.0706	15.958	-16.0564	-62.88
32	2.1452	0.3579	0.6873	1.2675	-1.0482	1.3397	0.5679	0.5651	-0.3108	-0.6933	-0.3043	0.1929	1.0178	1.0854	-0.2636	0.4051	0.4239	-0.2049	0.2991	-0.1061	0.0703	12.4918	-22.3684	-70.3212
33	2.2193	1.819	0.2219	2.7269	-1.6296	4.8208	-0.1915	0.0043	-0.1723	-0.0505	-0.0985	-0.433	0.8263	0.6355	0.29	0.0767	0.1993	-0.1186	0.0334	-0.0277	0.0944	3.8463	-27.8147	-61.4487
34	0.7199	-0.2745	-0.3006	0.671	0.2211	1.19	0.0252	-0.1001	0.033	-0.0969	-0.0501	-0.0587	-0.0781	-0.1329	0.0249	0.0487	0.0161	-0.0039	0.1014	0.0113	0.0116	-17.5601	3.9068	-61.3616
35	0.4988	-0.129	-0.5053	4.5268	-1.0538	2.0305	-0.2681	-0.1051	-0.0489	0.3316	0.0825	-0.2031	0.2917	0.0305	0.1856	0.1389	0.0226	0.0513	0.0314	-0.0162	-0.0253	-18.2955	-11.7276	-51.1008
36	1.5816	0.9552	-0.5853	4.5565	-0.9137	0.8659	-0.1947	-0.2051	-0.1845	-0.1792	0.0228	0.0355	0.396	0.0682	0.1719	0.1445	0.0134	0.068	0.0515	0.0407	-0.0007	-22.5416	-18.3581	-50.8184
37	2.8936	0.9922	1.311	0.3403	0.4399	1.9622	-0.2512	0.1127	-0.6944	1.4096	0.2792	-0.6266	0.4221	0.5445	-0.028	0.2404	0.0839	0.1988	0.1493	-0.0072	0.1746	-18.3973	-23.5486	-66.2226
38	2.6419	-0.0106	-1.6138	1.2788	-0.4841	4.0281	-0.2578	0.3172	-0.0733	-0.0864	0.1233	0.0264	0.5581	-0.0903	0.1346	0.1326	-0.047	0.0405	-0.007	-0.0357	-0.0351	-18.9145	-11.1936	-70.0649
39	11.9504	-3.8102	5.6943	1.5295	-1.9587	3.4829	0.1502	-0.1303	-0.6508	-0.0351	-0.014	0.0443	0.2783	0.2514	-0.1362	0.0526	0.0952	0.023	0.1933	0.0812	0.0847	6.9812	-14.8421	-56.8683
40	7.4155	-3.4702	-9.195	1.624	4.303	11.4015	-0.3717	2.487	-1.197	1.7306	-1.4382	-2.4438	0.8956	0.1338	1.8099	0.238	0.0501	-0.0273	0.1628	0.0004	0.1637	7.3209	-29.1313	-52.946

Refinement TLS group

Refine-ID: X-RAY DIFFRACTION / Selection: ALL

ID	Refine TLS-ID	Auth asym-ID	Label asym-ID	Auth seq-ID	Label seq-ID
1	1	A	A	6 - 21	8 - 23
2	2	A	A	22 - 43	24 - 45
3	3	A	A	44 - 122	46 - 124
4	4	A	A	123 - 145	125 - 147
5	5	A	A	146 - 164	148 - 166
6	6	A	A	165 - 180	167 - 182
7	7	A	A	181 - 200	183 - 202
8	8	A	A	201 - 231	203 - 233
9	9	A	A	232 - 283	234 - 285
10	10	A	A	284 - 322	286 - 324
11	11	B	B	6 - 25	8 - 27
12	12	B	B	26 - 56	28 - 58
13	13	B	B	57 - 66	59 - 68
14	14	B	B	67 - 119	69 - 121
15	15	B	B	120 - 143	122 - 145
16	16	B	B	144 - 180	146 - 182
17	17	B	B	181 - 197	183 - 199
18	18	B	B	198 - 215	200 - 217
19	19	B	B	216 - 284	218 - 286
20	20	B	B	285 - 322	287 - 324
21	21	C	C	5 - 11	7 - 13
22	22	C	C	12 - 26	14 - 28
23	23	C	C	27 - 43	29 - 45
24	24	C	C	44 - 70	46 - 72
25	25	C	C	71 - 153	73 - 155
26	26	C	C	154 - 166	156 - 168
27	27	C	C	167 - 200	169 - 202
28	28	C	C	201 - 240	203 - 242
29	29	C	C	241 - 315	243 - 317
30	30	C	C	316 - 321	318 - 323
31	31	D	D	6 - 18	8 - 20
32	32	D	D	19 - 69	21 - 71
33	33	D	D	70 - 100	72 - 102
34	34	D	D	101 - 141	103 - 143
35	35	D	D	142 - 167	144 - 169
36	36	D	D	168 - 209	170 - 211
37	37	D	D	210 - 224	212 - 226
38	38	D	D	225 - 285	227 - 287
39	39	D	D	286 - 312	288 - 314
40	40	D	D	313 - 322	315 - 324

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