- PDB-2e6l: structure of mouse WRN exonuclease domain -
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Basic information
Entry
Database: PDB / ID: 2e6l
Title
structure of mouse WRN exonuclease domain
Components
Werner syndrome ATP-dependent helicase homolog
Keywords
HYDROLASE / Zn-protein complex
Function / homology
Function and homology information
Processive synthesis on the C-strand of the telomere / Removal of the Flap Intermediate from the C-strand / Homologous DNA Pairing and Strand Exchange / Presynaptic phase of homologous DNA pairing and strand exchange / Resolution of D-loop Structures through Holliday Junction Intermediates / 3'-flap-structured DNA binding / positive regulation of strand invasion / HDR through Single Strand Annealing (SSA) / telomeric G-quadruplex DNA binding / HDR through Homologous Recombination (HRR) ...Processive synthesis on the C-strand of the telomere / Removal of the Flap Intermediate from the C-strand / Homologous DNA Pairing and Strand Exchange / Presynaptic phase of homologous DNA pairing and strand exchange / Resolution of D-loop Structures through Holliday Junction Intermediates / 3'-flap-structured DNA binding / positive regulation of strand invasion / HDR through Single Strand Annealing (SSA) / telomeric G-quadruplex DNA binding / HDR through Homologous Recombination (HRR) / G2/M DNA damage checkpoint / forked DNA-dependent helicase activity / 8-hydroxy-2'-deoxyguanosine DNA binding / telomeric D-loop binding / Processing of DNA double-strand break ends / regulation of growth rate / G-quadruplex DNA unwinding / telomeric D-loop disassembly / Y-form DNA binding / four-way junction helicase activity / MutLalpha complex binding / Regulation of TP53 Activity through Phosphorylation / bubble DNA binding / protein localization to nucleolus / DNA 3'-5' helicase / exonuclease activity / response to UV-C / DNA metabolic process / DNA synthesis involved in DNA repair / replication fork processing / DNA unwinding involved in DNA replication / 3'-5' DNA helicase activity / replicative senescence / four-way junction DNA binding / DNA helicase activity / isomerase activity / 3'-5' exonuclease activity / cellular response to starvation / telomere maintenance / replication fork / determination of adult lifespan / double-strand break repair via homologous recombination / base-excision repair / cellular response to gamma radiation / cellular senescence / double-strand break repair / chromosome / manganese ion binding / regulation of apoptotic process / DNA replication / response to oxidative stress / chromosome, telomeric region / Hydrolases; Acting on ester bonds / nuclear speck / centrosome / chromatin binding / nucleolus / magnesium ion binding / protein homodimerization activity / ATP hydrolysis activity / nucleoplasm / ATP binding / nucleus / cytoplasm Similarity search - Function
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